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  • Zhou, Jiang, Dai et al report that upon ultraviolet-C radiation, full-length GSDME can induce pyroptosis without cleavage, likely due to conformational change and oxidative oligomerization after increased PARylation and mitochondrial lipid ROS levels.

    • Bo Zhou
    • Zhi-hong Jiang
    • Qiao Wu
    Article
  • The role of RNA in preserving the integrity and dynamics of membrane-bound organelles remains largely unexplored. A study now identifies the Golgi-resident protein GM130 as an RNA-binding protein that scaffolds the Golgi ribbon in a polyadenylated-RNA-dependent manner.

    • Fátima Gebauer
    News & Views
  • In two independent studies, Sun, Liu et al. and Sun et al. develop SPATAC-seq to map the chromatin accessibility landscape of zebrafish embryogenesis and mouse organogenesis, respectively, and identify transcription regulators that determine cell fate.

    • Keyong Sun
    • Xin Liu
    • Xun Lan
    Resource
  • Transcription factors (TFs) and cis-regulatory elements (CREs) drive organism development. Suboptimal binding of TFs to CREs is shown to be key for the specificity of gene expression. New work now indicates that a similar principle governs the activities of TFs and their regulatory specificity.

    • Jie Xu
    • Bing Ren
    News & Views
  • Cellular organelles form an interconnected and dynamic network that orchestrates cellular functions. Using a multispectral imaging and computational analysis approach (‘OrgaPlexing’), a study now identifies multi-organelle units as crucial regulators of metabolic reprogramming in primary macrophages upon inflammatory stimuli.

    • Johannes Pilic
    • Tatjana Kleele
    News & Views
  • The subcellular localization of numerous mRNAs has been demonstrated. This Review presents the different means of mRNA localization described and discusses how they can account for the widespread occurrence of this phenomenon.

    • Marina Chekulaeva
    Review Article
  • Agarwal et al. and Wang et al. show that vesicle-associated membrane protein 2 (VAMP2) interacts with and regulates alpha-synuclein biomolecular condensation, affecting α-synuclein function, which may prevent pathological amyloid aggregation.

    • Chuchu Wang
    • Kai Zhang
    • Jiajie Diao
    Article
  • Agarwal et al. show that vesicle-associated membrane protein 2 interacts with and regulates α-synuclein biomolecular condensation, affecting α-synuclein function, which may prevent pathological amyloid aggregation.

    • Aishwarya Agarwal
    • Aswathy Chandran
    • Janin Lautenschläger
    ArticleOpen Access