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  • An ependymoma subtype is driven by fusion proteins related to the transcriptional regulator YAP1. Research now shows that localization of these fusion proteins within nuclear condensates is necessary and sufficient for tumour formation through the activation of various genetic and epigenetic oncogenic mechanisms.

    • Mahsa Shahidi Dadras
    • Howard A. Fine
    News & Views
  • Lotfollahi et al. present ExpiMap, a deep-learning model enabling interpretable reference mapping of RNA sequencing data using biologically defined entities, offering end-to-end analysis from dataset integration to functional interpretation.

    • Mohammad Lotfollahi
    • Sergei Rybakov
    • Fabian J. Theis
    Technical Report Open Access
  • Daylon James in an associate professor at Weill Cornell Medicine in New York, where his work focuses on reproductive biology and cell-based approaches for treating infertility. Arun Sharma is an assistant professor at the Cedars-Sinai Medical Center Regenerative Medicine Institute, and his lab works on modelling cardiovascular diseases and developing cell-based screening platforms for drug toxicity. Many of us also know them as the hosts of the Stem Cell Podcast. Here, we ask them about the podcast and discuss their view on the stem cell field and science communication.

    • Stylianos Lefkopoulos
  • Contraction of the hair follicle-lining dermal sheath smooth muscle generates the forces necessary for the tissue remodelling that takes place during the regression phase of the hair growth cycle. This study reveals that endothelin signalling — from epithelial progenitors at the follicle bottleneck region to its neighbouring dermal sheath — is the main contraction-activating pathway.

    Research Briefing
  • Kara McKinley is an assistant professor of stem-cell and regenerative biology at Harvard University. In addition to advancing our understanding of endometrial regeneration, she has tackled the gender bias in the academic job market by founding the ‘Leading Edge Fellows’ program. Nature Cell Biology contacted her to discuss her career and goals for our research community.

    • Melina Casadio
  • The Institute of Molecular and Cell Biology (IMCB) in Singapore has helped the local scientific community to grow. Nature Cell Biology spoke to Wanjin Hong (executive director at A*STAR’s IMCB) and Guillaume Thibault (associate professor affiliated with Nanyang Technological University Singapore, National University of Singapore and A*STAR’s IMCB), who have dedicated parts of their careers to the growth of cell biology research in Singapore, about the history and directions of cell biological research programs in Singapore.

    • Melina Casadio
  • Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane. A study now suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ.

    • Deguang Liang
    • Xuejun Jiang
    News & Views
  • Tight regulation of the activity of EWS–ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.

    • April A. Apfelbaum
    • Elizabeth R. Lawlor
    News & Views
  • Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs — including linear RNAs and circular RNAs (circRNAs) — from a single gene locus. The names given to circRNAs are often ambiguous and lack consistency across studies. This Comment calls on the community to embrace a common nomenclature for naming circRNAs to ensure clarity and reproducibility.

    • Ling-Ling Chen
    • Albrecht Bindereif
    • Fangqing Zhao