Non-invasive and high-throughput interrogation of exon-specific isoform expression

  • Dong-Jiunn Jeffery Truong
  • Teeradon Phlairaharn
  • Gil Gregor Westmeyer
Technical Report

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    • Intestinal organoids have been used to model development of the crypt–villus axis and uncover signalling pathways that govern the stem-cell niche and induce differentiation. Two studies now take advantage of intestinal organoids to measure the mechanical forces that drive morphogenesis of the crypt and fate specification of its resident cells.

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    • Transcription-coupled repair of DNA lesions takes place across all domains of life. A transcription-elongation factor, ELOF1, highly conserved in eukaryotes, has now been shown to play a key role in this process. Importantly, these findings also include evidence of a second transcription-coupled repair pathway in mammalian cells.

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    • COVID-19 has led to a global pandemic, but the long-term immunological effects of the infection are only partially understood. A new study now provides important new clues by describing the transcriptional and epigenetic processes behind the immune memory of both adaptive and innate immune cells in individuals who have recovered from COVID-19.

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    • In this Perspective, Fuxreiter and Vendruscolo discuss the fundamental nature of the droplet and amyloid states of proteins, the regulatory mechanisms controlling their formation, and the cellular functions associated with these condensed states.

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    • The vascular system, plastic and positioned in the vicinity of tissues, is an undervalued regulator of adult stem cells. Two studies now show that the vascular-like Drosophila trachea is reshaped after intestinal damage or tumour formation and that this remodelling is required for compensatory intestinal stem cell proliferation and tumour growth.

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  • Advances in CRISPR-based systems have greatly expanded the molecular toolbox for biologists. In this issue, we present the first of a Series of commissioned Review articles that highlight the progress made using CRISPR–Cas9 technology and its relevance for cell biological research.

    Editorial
  • Our mentor, Suzanne Eaton, tragically fell victim to homicide on 2 July 2019. The circumstances of her disappearance and death have shocked scientists and the public alike, worldwide. From the moment she went missing, the members of her family, laboratory and colleagues have received admirable and touching support from the scientific community. This outpouring stands testament to the inspiration that Suzanne—a world-leader scientist, creative pioneer and beloved mentor—is to all of us.

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Series on CRISPR technology

Series on CRISPR technology

In this Series, we present commissioned Perspective and Review articles that highlight the progress made using CRISPR–Cas9 technology and its relevance for cell biological research.
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