cells in fuchsia and blue

Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis

  • Katrina T. Evans
  • Kerrigan Blake
  • Devon A. Lawson


  • Artist's rendition of extracellular vesicles

    This Collection highlights selected articles from across the Nature Portfolio that document the recent progress in understanding the biology of Extracellular Vesicle-mediated cell–cell communication and advances in clinical translation of EVs.

  • Representation of 3D cells on a grid

    This collection highlights recent papers published in Nature Portfolio journals on topics across embryonic development & stem cells, reproductive biology, synthetic tissues & embryo models, clinical & translational research and tissue stem cells.

  • To address health disparities and facilitate increasingly personalized treatments, Horwitz, Riley, Millan & Gunawardane call for the development of new models for basic and disease research that reflect diverse ancestral backgrounds and sex, and for the inclusion of diverse populations among donors and research participants.

Nature Cell Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered that inhibition of mitochondrial pyruvate uptake results in large-scale chromatin remodelling of key lineage-specific genes, antagonizes luminal lineage identity, and alters response to antiandrogen therapy in prostate cancer.

      Research Briefing
    • Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal and luminal prostate cells have distinct metabolic profiles, with a basal-to-luminal shift intensifying pyruvate oxidation. Metabolic changes in turn influence chromatin architecture, lineage reprogramming and treatment sensitivity.

      • Martin K. Bakht
      • Himisha Beltran
      News & Views
    • There is increasing interest in approaches that target and eliminate senescent cells. A study reports that the coatomer complex I (COPI) pathway is important for the survival of senescent cells, and suggests that targeting this pathway could hold therapeutic promise in the context of senescence-associated diseases.

      • Stella Victorelli
      • João F. Passos
      News & Views
    • The main barriers for intracellular receptors to sense circulating pathogen-associated molecular patterns (PAMPs) is how these PAMPs enter the cells. A study reveals that extracellular vesicles (EVs) bind lipopolysaccharide (LPS) via the lipid bilayer and mediates LPS intracellular transfer in a CD14-dependent endocytosis to activate noncanonical NLRP3 inflammasome and pyroptosis.

      • Yi Huang
      • Rongbin Zhou
      News & Views
  • Cell death is an important biological process whose experimental detection and measurement can be difficult, especially when examining many conditions in parallel. The interpretation of cell death data is complicated by the diversity of measurement techniques and lack of standardized methods in the field. Here, we offer tips to help interpret cell death experiments.

    • Scott J. Dixon
    • Michael J. Lee
  • Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific advances require meticulous experimental work and a refined ethical framework, but also sensible public communication. Securing public support is essential to achieve societal impact.

    • Nicolas C. Rivron
    • Alfonso Martinez-Arias
    • Kazuto Kato
  • Conferences are often held at different venues and feature innovative scientific programs; however, their design rarely changes, and barriers that exclude marginalized scientists persist. We discuss why this is a problem and offer suggestions for people and organizations seeking to create more inclusive and sustainable scientific meetings.

    • Silke Blair Chalmers
    • Suzanne Madgwick
    • Felicity Mae Davis

Human BioMolecular Atlas Program

Inaugurated in 2018, the Human BioMolecular Atlas Program (HuBMAP) endeavours to construct comprehensive spatial maps that feature a range of biomolecules such as RNA, proteins, and metabolites in human organs at single-cell resolution.


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