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    • Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that a phosphorylated EZH2 interacts with the androgen receptor (AR) and reprograms AR transcriptional activity to facilitate transition of CRPC into a lineage infidelity state.

      • Li Xin
      News & Views
    • Mice deficient in the piRNA pathway display sterility only in males. Taking advantage of a more representative piRNA pathway in golden hamsters, three studies now demonstrate that the piRNA pathway is essential for fertility in hamsters of both sexes and thus strongly link this small RNA pathway to fertility regulation in both men and women.

      • Yongjuan Guan
      • P. Jeremy Wang
      News & Views
    • Stem cells are the functional units of tissue repair but do not act alone. Studies on flatworms now reveal specialized populations of differentiated cells that transiently emerge to coordinate whole-body regeneration. The stem-cell-centric view of repair processes must be revised to account for the importance of cell fate dynamics beyond the niche.

      • Stephanie J. Ellis
      • Elaine Fuchs
      News & Views
    • Tissue-resident stem cells are capable of remarkable plasticity in areas of tissue damage, where inflammatory cells accumulate as part of the reparative response. A study in the lung now provides critical insight on how inflammatory signals alter cell-to-cell Notch signalling within the airway niche to drive stem cell plasticity.

      • Jaymin J. Kathiriya
      • Tien Peng
      News & Views
    • With advanced high-throughput technologies, scientists can now use transcriptional signatures to study melanocytes as they become cancer. A new study identifies transcriptional programs at single-cell resolution across platforms and species, which enables prediction of melanoma prognosis and response to immune-checkpoint inhibitor therapy.

      • Alicia M. McConnell
      • Leonard I. Zon
      News & Views
Series on CRISPR technology

Series on CRISPR technology

In this Series, we present commissioned Perspective and Review articles that highlight the progress made using CRISPR–Cas9 technology and its relevance for cell biological research.
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