Images of skin cells in multicolour on a background of black

Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation

  • Miguel Bernabé-Rubio
  • Shahnawaz Ali
  • Fiona M. Watt


  • Artist's rendition of extracellular vesicles

    This Collection highlights selected articles from across the Nature Portfolio that document the recent progress in understanding the biology of Extracellular Vesicle-mediated cell–cell communication and advances in clinical translation of EVs.

  • Representation of 3D cells on a grid

    This collection highlights recent papers published in Nature Portfolio journals on topics across embryonic development & stem cells, reproductive biology, synthetic tissues & embryo models, clinical & translational research and tissue stem cells.

  • To address health disparities and facilitate increasingly personalized treatments, Horwitz, Riley, Millan & Gunawardane call for the development of new models for basic and disease research that reflect diverse ancestral backgrounds and sex, and for the inclusion of diverse populations among donors and research participants.

Nature Cell Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • In many species, maternally deposited Piwi-interacting RNAs (piRNAs) deliver intergenerational epigenetic information to protect progeny from transposon expansion or invasion. However, Y-chromosome-encoded piRNAs cannot be passed from mothers to male offspring, yet mothers use autosomally encoded piRNAs to allow sons to utilize their Y chromosome to protect against ‘selfish’ elements.

      Research Briefing
    • The molecular program of human germline commitment remains largely unknown. A new study delineates the multifaceted functions of DMRT1 in human germline development, particularly in the transition from early to late primordial germ cells.

      • Yongjie Lu
      • Peng Yuan
      • Jie Qiao
      News & Views
    • RNA modifications have emerged as key gene regulators. A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis.

      • Marta Montes
      • Maite Huarte
      News & Views
    • Embryonic diapause in development and paused pluripotency in embryonic stem cells result in a state of hypotranscription through mechanisms that remain unclear. A new study dissects the role of METTL3-deposited global m6A RNA methylation in mediating this transcriptional dormancy.

      • Xueting Xu
      • Baoming Qin
      News & Views
    • Genetic clearance of p16high senescent cells or the use of senolytics improved the efficacy of stem cell reprogramming in vitro and in vivo, and helped establish induced pluripotent stem cells with features of experimental totipotency. When ablation of p16high senescent cells was combined with partial four-factor reprogramming in vivo, we observed noticeable histopathological liver rejuvenation in aged mice.

      Research Briefing
  • In this issue, Jason Shapiro, Hsiang-Chun (Jimmy) Chang and colleagues identify a conserved role for the iron-binding histone demethylase KDM3B in sensing iron levels and regulating mTORC1 through transcriptional repression of key components of the mTORC1 pathway. In this Q&A, we discuss this manuscript’s findings and publishing journey with first authors Jason Shapiro and Jimmy Chang and corresponding author Hossein Ardehali. Hossein is currently the director of the Center for Molecular Cardiology at the Feinberg School of Medicine at Northwestern University in Chicago; Jason is an MD candidate graduating in 2024 at the Feinberg School of Medicine; and Jimmy is a resident physician in the Department of Pediatrics at the Baylor College of Medicine in Houston.

    • Melina Casadio
  • Shirin Bahmanyar is an associate professor of molecular, cellular & developmental biology at Yale University, CT, USA. Shirin’s lab studies the organization of the endoplasmic reticulum (ER) and nuclear envelope, their dynamics throughout the cell cycle, and their relationship to lipid metabolism. We reached out to Shirin and were delighted to hear her thoughts on open questions in this field and to learn more about her research background and interests.

    • Melina Casadio

Human BioMolecular Atlas Program

Inaugurated in 2018, the Human BioMolecular Atlas Program (HuBMAP) endeavours to construct comprehensive spatial maps that feature a range of biomolecules such as RNA, proteins, and metabolites in human organs at single-cell resolution.


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