• A swirl of cells in brightly contrasting colors

    In this collection, we highlight recent papers published across Nature Portfolio journals on topics including embryonic development and stem cells, clinical and translational research, stem cell-based tissue engineering, and tissue stem cells.

  • To address health disparities and facilitate increasingly personalized treatments, Horwitz, Riley, Millan & Gunawardane call for the development of new models for basic and disease research that reflect diverse ancestral backgrounds and sex, and for the inclusion of diverse populations among donors and research participants.

  • Developing embryos and organs

    Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts. The articles featured in this Collection highlight recent method developments and key resources that enable researchers to further explore the noncoding RNA field.

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    • Contraction of the hair follicle-lining dermal sheath smooth muscle generates the forces necessary for the tissue remodelling that takes place during the regression phase of the hair growth cycle. This study reveals that endothelin signalling — from epithelial progenitors at the follicle bottleneck region to its neighbouring dermal sheath — is the main contraction-activating pathway.

      Research Briefing
    • Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane. A study now suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ.

      • Deguang Liang
      • Xuejun Jiang
      News & Views
    • Tight regulation of the activity of EWS–ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.

      • April A. Apfelbaum
      • Elizabeth R. Lawlor
      News & Views
    • End-binding proteins attach to the dynamic plus-ends of microtubules in order to regulate microtubule polymerization and the transport of other plus-end tracking proteins (+TIPs). Three new studies dissect the multivalent interactions that constitute distinct +TIP networks and reveal that they give rise to liquid-like biomolecular condensates.

      • Bernardo Gouveia
      • Sabine Petry
      News & Views
    • The bone marrow is the daily production site for hundreds of billions of blood cells. A new study adds evidence that, during ageing, signals emanating from bone-marrow stromal cells shift to produce inflammatory factors that skew blood-cell output, driving age-related tissue deterioration.

      • Thomas H. Ambrosi
      • Charles K. F. Chan
      News & Views
  • Kara McKinley is an assistant professor of stem-cell and regenerative biology at Harvard University. In addition to advancing our understanding of endometrial regeneration, she has tackled the gender bias in the academic job market by founding the ‘Leading Edge Fellows’ program. Nature Cell Biology contacted her to discuss her career and goals for our research community.

    • Melina Casadio
  • The Institute of Molecular and Cell Biology (IMCB) in Singapore has helped the local scientific community to grow. Nature Cell Biology spoke to Wanjin Hong (executive director at A*STAR’s IMCB) and Guillaume Thibault (associate professor affiliated with Nanyang Technological University Singapore, National University of Singapore and A*STAR’s IMCB), who have dedicated parts of their careers to the growth of cell biology research in Singapore, about the history and directions of cell biological research programs in Singapore.

    • Melina Casadio
  • Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs — including linear RNAs and circular RNAs (circRNAs) — from a single gene locus. The names given to circRNAs are often ambiguous and lack consistency across studies. This Comment calls on the community to embrace a common nomenclature for naming circRNAs to ensure clarity and reproducibility.

    • Ling-Ling Chen
    • Albrecht Bindereif
    • Fangqing Zhao
Confetti conceptually illustrates a large diversity of noncoding RNA.

Methods for studying noncoding RNA

Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts.


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