Image of synthetic embryo-like structures self-organized from mouse trophoblast stem (TS), extra-embryonic endoderm (XEN), and embryonic stem (ES) cells in vivid colours of fuchsia, green and blue.

Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension

  • Min Bao
  • Jake Cornwall-Scoones
  • Magdalena Zernicka-Goetz
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    Join us November 1, 2022—November 3, 2022 for a virtual meeting presented by Nature Cell Biology, Nature Reviews Molecular and Cell Biology, and Nature Metabolism. We are pleased to bring together experts from diverse fields to discuss recent advances in understanding metabolic signalling pathways in organelles, cells, and tissues, and how these come together to control systemic metabolism.

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    In this collection, we highlight recent papers published across Nature Portfolio journals on topics including embryonic development and stem cells, clinical and translational research, stem cell-based tissue engineering, and tissue stem cells.

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    • Cellular senescence induced by DNA replication and telomere attrition contributes to organ dysfunction, inflammation and impaired immunity. A study reveals that antigen-presenting cells provide telomeric DNA to CD4+ T cells in synaptic contact, which enables the suspension of senescence, T cell expansion and long-lived immunity.

      • Anna Carey
      • Laura Niedernhofer
      • Christina Camell
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    • The Rag GTPases form the link between extracellular nutrients and the activation of mTORC1. RagA/B and RagC/D have been considered functionally redundant, but two studies now show that each isoform and gene have specific features, making their control of mTORC1 activity more nuanced and complex than previously appreciated.

      • Nicola Alesi
      • Elizabeth P. Henske
      News & Views
    • Aggregation of the RNA-binding protein TDP-43 is commonly observed in neurodegenerative disorders. A new study reveals that this process may be blocked by HSPB1, a small heat shock protein that can also regulate TDP-43 phase separation. This may be relevant to neurodegeneration, as loss of HSPB1 correlates with TDP-43 pathology.

      • Yuna M. Ayala
      • Zachary R. Grese
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    • The mechanisms that underlie cell identity remain poorly understood. A study now dissects the transcriptional trajectories of single cells undergoing malignant transformation or reprogramming to pluripotency and reveals regulators of cell plasticity in these biological processes.

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Metabolic communication across biological scales

This Collection showcases recent articles from Nature Cell Biology, Nature Metabolism and Nature Reviews Molecular Cell Biology covering cellular to systemic metabolic regulation. This selection accompanies the Nature Conference “Metabolic Communication Across Biological Scales” and provides a resource about current trends and directions in this field.
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