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Monocytes deposit migrasomes to promote embryonic angiogenesis

  • Cuifang Zhang
  • Tianqi Li
  • Li Yu
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    In this collection, we highlight recent papers published across Nature Portfolio journals on topics including embryonic development and stem cells, clinical and translational research, stem cell-based tissue engineering, and tissue stem cells.

  • To address health disparities and facilitate increasingly personalized treatments, Horwitz, Riley, Millan & Gunawardane call for the development of new models for basic and disease research that reflect diverse ancestral backgrounds and sex, and for the inclusion of diverse populations among donors and research participants.

  • Developing embryos and organs

    Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts. The articles featured in this Collection highlight recent method developments and key resources that enable researchers to further explore the noncoding RNA field.

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      News & Views
    • Several new technologies have used synthetic RNAs that leverage the cell’s RNA splicing machinery to drive the expression of gene products. A new study now reports a technique to dynamically and non-invasively monitor gene expression by embedding reporters within introns contained in the parent gene.

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    • FG-nucleoporins of the nuclear pore complexes form a permeability barrier between the nucleus and the cytosol. FG-nucleoporins contain disordered regions and are prone to aggregation. Two studies identify the chaperone DNAJB6 as a key factor that prevents aggregation of FG-nucleoporins and assists in the biogenesis of nuclear pore complexes.

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    • PTEN, a tumour suppressor, also regulates T cell activation. A new study reports that PTEN acts as a cell-intrinsic rheostat linking TCR- and IL-23-mediated signalling to regulate development of type-17 innate-like T cells in the thymus. This work may have important implications for treating autoimmune and inflammatory diseases.

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    • In tumours, cancer cells can overcome energy stress via differential regulation of non-canonical ‘moonlighting’ functions of metabolic enzymes. A study now shows that the metabolic phosphatase fructose-1,6-bisphosphatase 1 (FBP1) can act as a nuclear protein phosphatase and reveals how this process is inhibited in cancer cells.

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  • Publicly shared metabolomics data may contain key answers to central questions in cell biology, but re-use of the data is complicated by the lack of standardized experimental and computational methods in the field. This Comment provides some tips to help ensure that shared metabolomics data are re-used appropriately.

    • Ethan Stancliffe
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    Comment
  • For the past 40 years, minimal reconstituted systems have helped cell biologists to understand the mechanisms that underlie membrane traffic. Having progressed from minimal synthetic and cell-derived ensembles to direct comparison with living systems, reconstitution is poised for ever more precise and informative understanding of membrane biology.

    • Jeanne C. Stachowiak
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    Comment
  • We highlight the expanding world of noncoding RNA biology in a Collection of articles from Nature research journals that discuss recent technological advances, approaches and emerging models driving this rapidly advancing field.

    Editorial
Confetti conceptually illustrates a large diversity of noncoding RNA.

Methods for studying noncoding RNA

Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts.
Collection

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