Molecular structure on a background of yellow fading to pink

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

  • Raffaele Nicastro
  • Laura Brohée
  • Constantinos Demetriades


  • Artist's rendition of extracellular vesicles

    This Collection highlights selected articles from across the Nature Portfolio that document the recent progress in understanding the biology of Extracellular Vesicle-mediated cell–cell communication and advances in clinical translation of EVs.

  • Representation of 3D cells on a grid

    This collection highlights recent papers published in Nature Portfolio journals on topics across embryonic development & stem cells, reproductive biology, synthetic tissues & embryo models, clinical & translational research and tissue stem cells.

  • To address health disparities and facilitate increasingly personalized treatments, Horwitz, Riley, Millan & Gunawardane call for the development of new models for basic and disease research that reflect diverse ancestral backgrounds and sex, and for the inclusion of diverse populations among donors and research participants.

Nature Cell Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • The molecular program of human germline commitment remains largely unknown. A new study delineates the multifaceted functions of DMRT1 in human germline development, particularly in the transition from early to late primordial germ cells.

      • Yongjie Lu
      • Peng Yuan
      • Jie Qiao
      News & Views
    • RNA modifications have emerged as key gene regulators. A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis.

      • Marta Montes
      • Maite Huarte
      News & Views
    • Embryonic diapause in development and paused pluripotency in embryonic stem cells result in a state of hypotranscription through mechanisms that remain unclear. A new study dissects the role of METTL3-deposited global m6A RNA methylation in mediating this transcriptional dormancy.

      • Xueting Xu
      • Baoming Qin
      News & Views
    • Genetic clearance of p16high senescent cells or the use of senolytics improved the efficacy of stem cell reprogramming in vitro and in vivo, and helped establish induced pluripotent stem cells with features of experimental totipotency. When ablation of p16high senescent cells was combined with partial four-factor reprogramming in vivo, we observed noticeable histopathological liver rejuvenation in aged mice.

      Research Briefing
    • Pathways linked to the modification of RNA with N6-methyladenosine (m6A) are known to be involved in initiating and maintaining cancer. But many of the key components of these pathways remain undiscovered. The RBFOX2 protein has now been identified as an m6A reader involved in locus-specific chromatin regulation, with therapeutic implications for myeloid leukaemia.

      • James Russell
      • Konstantinos Tzelepis
      News & Views
  • Shirin Bahmanyar is an associate professor of molecular, cellular & developmental biology at Yale University, CT, USA. Shirin’s lab studies the organization of the endoplasmic reticulum (ER) and nuclear envelope, their dynamics throughout the cell cycle, and their relationship to lipid metabolism. We reached out to Shirin and were delighted to hear her thoughts on open questions in this field and to learn more about her research background and interests.

    • Melina Casadio
  • Kelly Stevens is an associate professor in the departments of Bioengineering and Laboratory Medicine & Pathology at the University of Washington. We spoke with her and discussed her work, her views on diversity and its importance, but also her personal struggles as an LGBT+ and disabled scientist.

    • Stylianos Lefkopoulos

Human BioMolecular Atlas Program

Inaugurated in 2018, the Human BioMolecular Atlas Program (HuBMAP) endeavours to construct comprehensive spatial maps that feature a range of biomolecules such as RNA, proteins, and metabolites in human organs at single-cell resolution.


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