Cells in multicolor on a black background

Pooled multicolour tagging for visualizing subcellular protein dynamics

  • Andreas Reicher
  • Jiří Reiniš
  • Stefan Kubicek


  • Representation of 3D cells on a grid

    This collection highlights recent papers published in Nature Portfolio journals on topics across embryonic development & stem cells, reproductive biology, synthetic tissues & embryo models, clinical & translational research and tissue stem cells.

  • Person viewing organisms through a microscope

    Intellectual freedom for scientists, unconstrained by commercial interests and direct application, fuels unexpected discoveries. Curiosity-driven, basic science has yielded a deeper understanding of how life forms develop and function in their environment and has had wide implications for health and our planet. Investing in this is vital for scientific progress and worth protecting in a democracy.

  • Cells in blue forming the number 25

    We celebrate our 25th anniversary with this Focus & Collection. We not only look back through biological discoveries, but also discuss the roles of cell biologists in sustainability, our ongoing commitments to DEI, and mentoring the next generation.

Nature Cell Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • Biological clocks can be used to evaluate the age of a cell or organisms. This Perspective proposes the concept of an intrinsically disordered protein (IDP) clock, whereby the aggregation state of an IDP encodes for a biological ageing signature.

      • Dorothee Dormann
      • Edward Anton Lemke
    • Granath-Panelo and Kajimura review emerging evidence of mitochondrial heterogeneity in different contexts and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling.

      • Melia Granath-Panelo
      • Shingo Kajimura
      Review Article
    • Two new landmark studies use innovative and complementary lineage tracing approaches in human cerebral organoids to reveal symmetric stem cell division and direct neurogenesis of basal radial glial cells to enable cortical growth, expansion and differentiation.

      • Yechiel Elkabetz
      News & Views
    • Metastatic colonization involves cancer-cell-intrinsic mechanisms and microenvironmental interactions, and a better understanding of the factors that influence the final, post-extravasation phases is crucial for therapeutically targeting metatstasis.

      • Arthur W. Lambert
      • Yun Zhang
      • Robert A. Weinberg
      Review Article
    • We show that the mitochondrial fission proteins MiD49 and MiD51 are activated by fatty acyl-coenzyme A (FA-CoA). FA-CoA binds in a previously identified pocket located within MiDs, inducing their oligomerization and ability to activate the dynamin DRP1, ultimately promoting mitochondrial fission. Activated MiDs synergize with mitochondrial fission factor (MFF) in stimulating DRP1 activity, leading us to hypothesize that MiDs act upstream of MFF during mitochondrial fission.

      Research Briefing
  • Volume electron microscopy (vEM) generates large 3D volumes of cells or tissues at nanoscale resolutions, enabling analyses of organelles in their cellular environment. Here, we provide examples of vEM in cell biology and discuss community efforts to develop standards in sample preparation and image acquisition for enhanced reproducibility and data reuse.

    • Kirk James Czymmek
    • Ilya Belevich
    • Eija Jokitalo
  • Despite the constant renewal of their components, cellular actin networks maintain their overall appearance, through a subtle balance of filament assembly and disassembly. This balance is key to the remodelling of cellular architecture. We discuss the significance of in vitro reconstitutions in deciphering the complexity of actin regulation.

    • Manuel Théry
    • Laurent Blanchoin
  • Scientists must actively advocate for infrastructure development and funding of emerging research directions through collective efforts. In India, this has been crucial to help reverse the brain drain and enable equitable contributions to research and development at the global level.

    • Arun K. Shukla
    World View
  • In this piece, I share a personal encounter that underscores the glaring gaps in conference accessibility and challenges faced by disabled academics. I reveal historical biases and resistance to change and propose ways to transform conferences into more inclusive spaces, ensuring that all scientists can fully participate in the scientific discourse.

    • Urszula Lucja McClurg
    World View
  • Eiji Hara is a professor at the Research Institute for Microbial Diseases, Osaka University, Japan. Eiji recalls the discovery of the basis for the irreversibility of cellular senescence, published in Nature Cell Biology in 2006.

    • Eiji Hara
    Turning Points


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