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  • Representation of 3D cells on a grid

    This collection highlights recent papers published in Nature Portfolio journals on topics across embryonic development & stem cells, reproductive biology, synthetic tissues & embryo models, clinical & translational research and tissue stem cells.

  • Person viewing organisms through a microscope

    Intellectual freedom for scientists, unconstrained by commercial interests and direct application, fuels unexpected discoveries. Curiosity-driven, basic science has yielded a deeper understanding of how life forms develop and function in their environment and has had wide implications for health and our planet. Investing in this is vital for scientific progress and worth protecting in a democracy.

  • Cells in blue forming the number 25

    We celebrate our 25th anniversary with this Focus & Collection. We not only look back through biological discoveries, but also discuss the roles of cell biologists in sustainability, our ongoing commitments to DEI, and mentoring the next generation.

Nature Cell Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

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    • Several processes of regulated cell death engage or use mitochondria, which are thus central hubs that not only coordinate cell death but also elicit non-lethal signalling mediated by mitochondrial outer membrane permeabilization.

      • Hannah L. Glover
      • Annabell Schreiner
      • Stephen W. G. Tait
      Review Article
    • Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferroptosis, which could be exploited to treat cancers.

      • Toshitaka Nakamura
      • Marcus Conrad
      Review Article
    • Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase (VARS) promotes therapeutic resistance of melanoma to MAPK pathway inhibitors by enhancing translation of valine-enriched genes, including the fatty acid oxidation gene HADH.

      • Qiushuang Wu
      • Sohail F. Tavazoie
      News & Views
    • Oocyte development involves the prolonged and intricate process of building a distinctive transcriptome and epigenome to anticipate embryogenesis after fertilization. Research now shows that mouse oocytes use an unusual chromatin signature to mark regulatory elements, and that the transcription factors TCF3 and TCF12 have a key role.

      • Qiqi Cao
      • Edward J. Grow
      News & Views
    • Sensing stress within the endoplasmic reticulum (ER), the ER transmembrane protein IRE1α initiates a signal transduction pathway to restore homeostasis. A study finds that this process requires an ER membrane-bound phase separation event that leads to the local assembly of stress granules (SGs) and delivery of signalling components.

      • David Pincus
      • Scott A. Oakes
      News & Views
  • Volume electron microscopy (vEM) generates large 3D volumes of cells or tissues at nanoscale resolutions, enabling analyses of organelles in their cellular environment. Here, we provide examples of vEM in cell biology and discuss community efforts to develop standards in sample preparation and image acquisition for enhanced reproducibility and data reuse.

    • Kirk James Czymmek
    • Ilya Belevich
    • Eija Jokitalo
    Comment
  • Despite the constant renewal of their components, cellular actin networks maintain their overall appearance, through a subtle balance of filament assembly and disassembly. This balance is key to the remodelling of cellular architecture. We discuss the significance of in vitro reconstitutions in deciphering the complexity of actin regulation.

    • Manuel Théry
    • Laurent Blanchoin
    Comment
  • Scientists must actively advocate for infrastructure development and funding of emerging research directions through collective efforts. In India, this has been crucial to help reverse the brain drain and enable equitable contributions to research and development at the global level.

    • Arun K. Shukla
    World View
  • In this piece, I share a personal encounter that underscores the glaring gaps in conference accessibility and challenges faced by disabled academics. I reveal historical biases and resistance to change and propose ways to transform conferences into more inclusive spaces, ensuring that all scientists can fully participate in the scientific discourse.

    • Urszula Lucja McClurg
    World View
  • Eiji Hara is a professor at the Research Institute for Microbial Diseases, Osaka University, Japan. Eiji recalls the discovery of the basis for the irreversibility of cellular senescence, published in Nature Cell Biology in 2006.

    • Eiji Hara
    Turning Points

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