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Latest Research

  • Review Article |

    In this Review, Doherty and Baehrecke discuss the multiple roles of autophagy during cell survival and cell death. They cover the interplay between autophagy, apoptosis and necrosis, as well as engulfment and inflammation.

    • Johnna Doherty
    •  & Eric H. Baehrecke
  • Article |

    Zhu et al. show that the long noncoding RNA lncGata6 enhances Wnt signalling in intestinal stem cells by recruiting the NURF remodelling complex onto the Ehf promoter and initiating its transcription, which triggers expression of Lgr4/5.

    • Pingping Zhu
    • , Jiayi Wu
    • , Yanying Wang
    • , Xiaoxiao Zhu
    • , Tiankun Lu
    • , Benyu Liu
    • , Luyun He
    • , Buqing Ye
    • , Shuo Wang
    • , Shu Meng
    • , Dongdong Fan
    • , Jing Wang
    • , Liuliu Yang
    • , Xiwen Qin
    • , Ying Du
    • , Chong Li
    • , Lei He
    • , Weizheng Ren
    • , Xin Wu
    • , Yong Tian
    •  & Zusen Fan
  • Letter |

    Using super-resolution microscopy, tracking of single particle trajectories of endoplasmic reticulum (ER) luminal proteins traversing tubular ER, and measuring ER dynamics, Holcman et al. show that ER content is propelled by active luminal flow.

    • David Holcman
    • , Pierre Parutto
    • , Joseph E. Chambers
    • , Marcus Fantham
    • , Laurence J. Young
    • , Stefan J. Marciniak
    • , Clemens F. Kaminski
    • , David Ron
    •  & Edward Avezov
  • Article |

    Barnes et al. report a dynamic and reciprocal crosstalk between tissue tension and glycocalyx bulkiness that promotes a mesenchymal, stem-like phenotype in GBM.

    • J. Matthew Barnes
    • , Shelly Kaushik
    • , Russell O. Bainer
    • , Jason K. Sa
    • , Elliot C. Woods
    • , FuiBoon Kai
    • , Laralynne Przybyla
    • , Mijeong Lee
    • , Hye Won Lee
    • , Jason C. Tung
    • , Ori Maller
    • , Alexander S. Barrett
    • , Kan V. Lu
    • , Jonathon N. Lakins
    • , Kirk C. Hansen
    • , Kirsten Obernier
    • , Arturo Alvarez-Buylla
    • , Gabriele Bergers
    • , Joanna J. Phillips
    • , Do-Hyun Nam
    • , Carolyn R. Bertozzi
    •  & Valerie M. Weaver
  • Letter |

    Studying early Drosophila wing epithelium development, Singh et al. find that individual cells are mechanically autonomous, and that their elongation along the proximal–distal axis is driven by polarized microtubule-mediated pushing forces.

    • Amrita Singh
    • , Tanumoy Saha
    • , Isabell Begemann
    • , Andrea Ricker
    • , Harald Nüsse
    • , Oliver Thorn-Seshold
    • , Jürgen Klingauf
    • , Milos Galic
    •  & Maja Matis
  • Article |

    Zhang et al. show that BAP1 suppresses SLC7A11 expression and cystine uptake, thereby promoting ferroptosis and inhibiting tumour growth.

    • Yilei Zhang
    • , Jiejun Shi
    • , Xiaoguang Liu
    • , Li Feng
    • , Zihua Gong
    • , Pranavi Koppula
    • , Kapil Sirohi
    • , Xu Li
    • , Yongkun Wei
    • , Hyemin Lee
    • , Li Zhuang
    • , Gang Chen
    • , Zhen-Dong Xiao
    • , Mien-Chie Hung
    • , Junjie Chen
    • , Peng Huang
    • , Wei Li
    •  & Boyi Gan

News & Comment

  • News & Views |

    Ferroptosis is a regulated non-apoptotic form of cell death and its functional role in tumorigenesis remains elusive. A study now shows that the tumour suppressor BAP1 enhances ferroptosis by modulating expression of the cystine transporter SLC7A11, leading to improved control of tumour growth.

    • Michael P. Murphy
  • News & Views |

    Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

    • Aaron M. Hosios
    •  & Brendan D. Manning
  • Turning Points |

    Serena is a Cancer Research UK Advanced Clinician Scientist at the University of Cambridge. She studies mutation patterns in human DNA and finds ways to make it applicable in a clinical setting. Serena is a mother of two, loves music and being outdoors, and fights the forties with kung fu.

    • Serena Nik-Zainal
  • Editorial |

    Open discourse to identify challenges and devise solutions is essential to abolish gender inequalities globally and in science. In our ‘Focus on Women in Science’, we celebrate the achievements and consider the concerns of women researchers from around the world, who share some of the turning points of their scientific careers.

  • News & Views |

    Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.

    • Michael Ebner
    •  & Volker Haucke
  • Turning Points |

    Melissa Little is an NHMRC Senior Principal Research Fellow and Cell Biology Theme Director at the Murdoch Children’s Research Institute in Melbourne, Australia. She also leads Stem Cells Australia, University of Melbourne. She studies kidney morphogenesis and regeneration using pluripotent stem cells.

    • Melissa Little

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