Reforms spell optimism for biological research in China

Latest Research

  • Article |

    Baarlink et al. identify a transient pool of nuclear F-actin, the dynamics of which are controlled by cofilin-1 that accumulates after mitosis and is important for chromatin reorganization in G1.

    • Christian Baarlink
    • , Matthias Plessner
    • , Alice Sherrard
    • , Kohtaro Morita
    • , Shinji Misu
    • , David Virant
    • , Eva-Maria Kleinschnitz
    • , Robert Harniman
    • , Dominic Alibhai
    • , Stefan Baumeister
    • , Kei Miyamoto
    • , Ulrike Endesfelder
    • , Abderrahmane Kaidi
    •  & Robert Grosse
  • Article |

    O’Farrell et al. show that class III PI3K regulates epithelial integrity through endosomal LKB1. Class III PI3K inactivation dysregulates LKB1 to alter cell polarity, and the PtdIns3P effector WDFY2 regulates LKB1.

    • Fergal O’Farrell
    • , Viola Hélène Lobert
    • , Marte Sneeggen
    • , Ashish Jain
    • , Nadja Sandra Katheder
    • , Eva Maria Wenzel
    • , Sebastian Wolfgang Schultz
    • , Kia Wee Tan
    • , Andreas Brech
    • , Harald Stenmark
    •  & Tor Erik Rusten
  • Letter |

    Cdk1-mediated phosphorylation of threonine and serine residues on cell cycle regulators needs to be removed after mitosis. Hein et al. show that the known preference of the PP2A–B55 phosphatase for threonine provides temporal regulation of mitotic exit.

    • Jamin B. Hein
    • , Emil P. T. Hertz
    • , Dimitriya H. Garvanska
    • , Thomas Kruse
    •  & Jakob Nilsson
  • Article |

    Liu et al. find that PKM2 methylated by CARM1 inhibits Ca2+ influx from endoplasmic reticulum to mitochondria, thus restraining mitochondrial oxidative phosphorylation while promoting aerobic glycolysis and breast cancer growth.

    • Fabao Liu
    • , Fengfei Ma
    • , Yuyuan Wang
    • , Ling Hao
    • , Hao Zeng
    • , Chenxi Jia
    • , Yidan Wang
    • , Peng Liu
    • , Irene M. Ong
    • , Baobin Li
    • , Guojun Chen
    • , Jiaoyang Jiang
    • , Shaoqin Gong
    • , Lingjun Li
    •  & Wei Xu
  • Article |

    In the developing mouse pancreas, EGFR regulates apical polarity via PI(3)K and Rac1 and elicits different ligand-dependent effects: BTC enables β-cell commitment and EGF inhibits polarization of epithelial progenitors during the primary transition.

    • Zarah M. Löf-Öhlin
    • , Pia Nyeng
    • , Matthew E. Bechard
    • , Katja Hess
    • , Eric Bankaitis
    • , Thomas U. Greiner
    • , Jacqueline Ameri
    • , Christopher V. Wright
    •  & Henrik Semb

News & Comment

  • News and Views |

    PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality.

    • Katharina Schlacher
  • News and Views |

    Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon.

    • Jeffrey W. Brown
    •  & Jason C. Mills
  • News and Views |

    A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.

    • Maria S. Soengas
    •  & Eva Hernando
  • News and Views |

    Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.

    • Catherine Rabouille
  • News and Views |

    It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. A study now shows that the regulated exposure of an unstructured region in yeast pyruvate kinase triggers reversible aggregation to preserve protein function under stress.

    • Jörg Höhfeld

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