Volume 42 Issue 7, July 2024

Targeted radiopharmaceuticals offer resistance-free potency, pre-treatment imaging and widespread combination potential. Big pharma and investors are piling in.

Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. Tome Biosciences inserts large DNA sequences into precise genomic locations, overcoming limitations of base and prime editing.

Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. Tenpoint Therapeutics optimizes delivery and generation of stem-cell-derived retinal cells for vision repair.

Errors in the US Patent and Trademark Office’s automated program to calculate patent expiration dates could result in hundreds of millions of dollars in added costs to drug prices.

Recent patents relating to systems and methods for super-resolution microscopy.

A DNA polymerase editing system offers advantages over prime editing.

Metabolites and RNA in a tissue section are profiled simultaneously.

Mapping fixed brain samples with extracellular labeling and optical microscopy reveals synaptic connections.

A potassium activity reporter detects organelle-specific channel function.

A probe reports absolute sodium levels in acidic organelles with single-organelle resolution.

Spectra decomposes gene expression data into interpretable programs using prior knowledge.

MaxFuse enables data integration between modalities even when features are weakly correlated.

A large resource of shared tumor neoepitopes aims to accelerate cancer immunotherapy.

A new RNA reference set improves detection of differential expression in clinical settings.

Multi-omics data are readily integrated using quartet reference materials.

The NIH Applicant Assistance Program represents a new paradigm guiding the design of meaningful policy interventions for increasing equity of participation in scientific grant funding.

A physician-scientist exploring the mechanisms and physiological relevance of glycoRNAs talks about being useful, the challenges of running a laboratory, and translating foundational knowledge into products that will benefit people.

Recent moves of note in and around the biotech and pharma industries.