Volume 40 Issue 5, May 2022

Editorial

Gene therapy at the crossroads

Two upcoming regulatory decisions represent a tipping point for commercial gene therapy, with implications for work on existing viral vectors and the pursuit of new ones.

Editorial 09 May 2022

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News

Base editing marches on the clinic

This year could see the first trials of therapies employing base editing that introduce precise single-nucleotide changes into patient genomes.

Michael Eisenstein
News 09 May 2022
FDA approves anti-LAG3 checkpoint

News in Brief 16 May 2022
Cosmetics: when biotech is better than nature

Biotech companies find success with sustainably sourced ingredients for the beauty market

Emily Waltz
News 16 May 2022
Startup tackles oncogene-rich ecDNA

News in Brief 16 May 2022
Fungal genomes scoured for drugs

News in Brief 16 May 2022
Climate-friendly couture

Emily Waltz
News 16 May 2022
Biotech news from around the world

News in Brief 16 May 2022
Data Page
- Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups
  
  Laura DeFrancesco
  Data Page 16 May 2022
- 1Q22 — Blood in the water
  
  Laura DeFrancesco
  Data Page 16 May 2022
News Feature
- Baby’s first genome
  
  Whole-genome sequencing may be the fastest way to diagnose rare complex diseases, but should it be incorporated into healthy newborn screening?
  
  Caroline Seydel
  News Feature 25 Apr 2022

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Bioentrepreneur

Building a Business
- Reflections on Alnylam
  
  Recollections from an extraordinary 19-year journey guiding a tiny startup with an unproven therapeutic modality into a mature drug company with marketed products and >1,600 employees in nearly 20 countries provide lessons for those seeking to create the culture and values that are core to biotech success.
  
  John Maraganore
  Building a Business 09 May 2022

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Features

Patents
- Relieving patent-eligibility barriers in biotech with a preparation or treatment method
  
  An analysis of decisions related to patent eligibility by the US Court of Appeals for the Federal Circuit indicates a way to avoid rejection or invalidation of eligibility.
  
  Jir-You Wang
  Yi-Fang Tsai
  Shyh-Jen Wang
  Patents 16 May 2022
- Chimeric antigen receptors
  
  Recent patents relating to methods of making and using chimeric antigen receptor (CAR)-T cells to treat cancer and other diseases.
  
  Patents 16 May 2022

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News & Views

Podcast
- Forum: CRISPR screening roundtable with Stegmaier and Doench
  
  Podcast 14 Apr 2022

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Research

Brief Communications
- Sensitive identification of neoantigens and cognate TCRs in human solid tumors
  
  NeoScreen helps identify rare tumor antigens for personalized cancer vaccines and T cell therapies.
  
  Marion Arnaud
  Johanna Chiffelle
  Alexandre Harari
  Brief Communication Open Access 15 Nov 2021
Articles
- Cell2location maps fine-grained cell types in spatial transcriptomics
  
  A Bayesian model maps the location of cell types in tissues with higher sensitivity.
  
  Vitalii Kleshchevnikov
  Artem Shmatko
  Omer Ali Bayraktar
  Article 13 Jan 2022
- Curated variation benchmarks for challenging medically relevant autosomal genes
  
  Variant detection in problematic genes is facilitated with a curated benchmark.
  
  Justin Wagner
  Nathan D. Olson
  Fritz J. Sedlazeck
  Article 07 Feb 2022
- Multiscale PHATE identifies multimodal signatures of COVID-19
  
  Disease signatures in high-dimensional biomedical data are detected with a visualization algorithm.
  
  Manik Kuchroo
  Jessie Huang
  Smita Krishnaswamy
  Article 28 Feb 2022
- A knowledge graph to interpret clinical proteomics data
  
  A knowledge graph platform integrates proteomics with other omics data and biomedical databases.
  
  Alberto Santos
  Ana R. Colaço
  Matthias Mann
  Article Open Access 31 Jan 2022
- scJoint integrates atlas-scale single-cell RNA-seq and ATAC-seq data with transfer learning
  
  Integration of data from single-cell RNA-seq and ATAC-seq is achieved with transfer learning.
  
  Yingxin Lin
  Tung-Yu Wu
  Y. X. Rachel Wang
  Article 20 Jan 2022
- Generating lineage-resolved, complete metagenome-assembled genomes from complex microbial communities
  
  Metagenome sequencing can now distinguish closely related microbes using long reads and haplotype phasing.
  
  Derek M. Bickhart
  Mikhail Kolmogorov
  Timothy P. L. Smith
  Article 03 Jan 2022
- Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
  
  Lineage tracing of human stem cells is achieved by measuring fluctuating DNA methylation.
  
  Calum Gabbutt
  Ryan O. Schenck
  Darryl Shibata
  Article Open Access 03 Jan 2022
- Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing
  
  Prime editing of large DNA sequences is achieved with two pegRNAs and site-specific recombinases.
  
  Andrew V. Anzalone
  Xin D. Gao
  David R. Liu
  
  Special:
  
  SCGE
  Article 09 Dec 2021
- Partitioning RNAs by length improves transcriptome reconstruction from short-read RNA-seq data
  
  The quality of RNA sequencing transcriptomes is improved when mRNAs are separated by length.
  
  Francisca Rojas Ringeling
  Shounak Chakraborty
  Stefan Canzar
  Article 10 Jan 2022
- Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides
  
  Polyketides, including a cannabinoid precursor, are produced in a slime mold.
  
  Christin Reimer
  Johann E. Kufs
  Falk Hillmann
  Article 06 Jan 2022
- CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
  
  Optimized guide RNAs improve RNA editing with endogenous enzymes.
  
  Philipp Reautschnig
  Nicolai Wahn
  Thorsten Stafforst
  Article 03 Jan 2022
- Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
  
  Antibodies that lock KRAS mutants in inactive conformations facilitate drug discovery.
  
  Christopher W. Davies
  Angela J. Oh
  Marie Evangelista
  Article 06 Jan 2022
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins
  
  Photoswitchable RNA-binding proteins enable the spatiotemporal control of RNA function.
  
  Renmei Liu
  Jing Yang
  Yi Yang
  Article 03 Jan 2022
- A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo
  
  A genetically encoded sensor reveals the dynamics of endocannabinoid signaling.
  
  Ao Dong
  Kaikai He
  Yulong Li
  Article 11 Nov 2021

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Amendments & Corrections

Author Correction: Engineered promoters enable constant gene expression at any copy number in bacteria

Thomas H. Segall-Shapiro
Eduardo D. Sontag
Christopher A. Voigt
Author Correction 07 Apr 2022
Publisher Correction: Diabetes cell therapies take evasive action

Elie Dolgin
Publisher Correction 22 Apr 2022
Publisher Correction: Bio-leather gears up to wow fashion industry

Emily Waltz
Publisher Correction 29 Apr 2022

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Careers & Recruitment

Career Feature
- First-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 16 May 2022
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 16 May 2022

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Volume 40 Issue 5, May 2022

Multiscale data visualization

Editorial

News

Data Page

News Feature

Bioentrepreneur

Building a Business

Features

Patents

News & Views

Podcast

Research

Brief Communications

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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