Volume 40 Issue 3, March 2022

Protective encapsulating devices and gene-editing technologies could obviate the need for antirejection drugs in stem-cell-derived therapies for diabetes.

Commercializing research is fraught with pitfalls, but a thoughtful checklist can ensure you set off on the right path and give your fledgling business the best chance of success.

Licensing provisions that obligate recipients of government funding to share relevant technology and know-how for scarce drugs during pandemics and epidemics can reduce shortages and overcome obstacles that intellectual property rights present.

Recent patents relating to methods, apparatus and algorithms for single-cell sequencing.

Regev, Theis and colleagues outline the challenges and concepts of the analysis of spatial transcriptomics data.

Single-cell sequencing reveals pre-activated immunity as important for milder COVID-19 symptoms in children.

Amplified loci in cancer genomes are directly targeted with triplex-forming oligonucleotides.

Two industrial chemicals are sustainably produced at large scale by microbial gas fermentation.

Baysor enables cell segmentation based on transcripts detected by multiplexed FISH or in situ sequencing.

Inter-sample variability reveals disease-associated cell subpopulations in single-cell RNA sequencing.

Simultaneous, Raman-based imaging of more than 10 proteins in thick samples.

Protein epitopes and chromatin accessibility are measured in single cells using phage display.

Phenotypic profiling of a phospho-deficient mutant library informs functional annotations of phosphosites.

Pooled and single-cell CRISPR screens provide a detailed map of human cytomegalovirus infection.

Stabilizing pegRNAs with 3′ RNA structures increases prime editing efficiency.

COSMIC outperforms spectral library search for metabolite annotation and annotates previously unseen structures.

Exploring the diversity of the wild progenitor of the wheat D subgenome allows for rapid trait discovery.

As innovations in the biotechnology sector continue to proliferate, the traditional education of medical students, residents and fellows will need to change to incorporate innovation as a core tenet of training.

Recent moves of note in and around the biotech and pharma industries.