Volume 40 Issue 2, February 2022

Editorial

The post-Theranos world

Advances in technology and changes to healthcare during the pandemic may finally realize the vision of patient-centric blood testing espoused by disgraced Theranos CEO Elizabeth Holmes.

Editorial 08 Feb 2022

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News

COVID-19 vaccine makers chase variant-ready vaccines

Omicron is prompting vaccine makers to look beyond SARS-CoV-2 spike protein and test whether T-cell immunity or multivalency can combat new variants

Cormac Sheridan
News 19 Jan 2022
Fashion’s microbial dyeing machines

Lisa Melton
News 15 Feb 2022
Rejuvenation by controlled reprogramming is the latest gambit in anti-aging

Startups are betting that partial reprogramming with Yamanaka factors may lead to age reversal, but hurdles remain.

Michael Eisenstein
News 19 Jan 2022
First pig-to-human heart

News in Brief 15 Feb 2022
Chroma to pioneer epigenetic editors

News in Brief 15 Feb 2022
African coronavirus surveillance network provides early warning for world

As Omicron spread across the globe, South African labs were the first to detect it and flag it to the world.

Paul Adepoju
News 20 Jan 2022
Biotech news from around the world

News in Brief 15 Feb 2022
Data Page
- Drug pipeline 4Q21
  
  Laura DeFrancesco
  Data Page 15 Feb 2022
- 2021 — the bubble’s hangover
  
  Laura DeFrancesco
  Data Page 15 Feb 2022
News Feature
- Fresh from the biotech pipeline: too much, too fast?
  
  2021 witnessed regulators’ continued push to accelerate approvals and adjust to COVID-19, but has the pendulum swung too far in drug makers’ favor?
  
  Melanie Senior
  News Feature 31 Jan 2022

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Correspondence

A Python library for probabilistic analysis of single-cell omics data

Adam Gayoso
Romain Lopez
Nir Yosef
Correspondence 07 Feb 2022

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Features

Patents
- Recent Orange and Purple Book legislation suggests a need to bridge drug and biologic patent regimes
  
  Additional changes could make the registries of drug patents published by the FDA, called the Orange and Purple Books, more useful and reduce barriers to effective competition from generic and biosimilar drugs.
  
  Bryan S. Walsh
  Jonathan J. Darrow
  Aaron S. Kesselheim
  Patents 15 Feb 2022
- Antivirals
  
  Recent patents relating to the synthesis, composition and uses of novel antiviral agents.
  
  Patents 15 Feb 2022

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News & Views

Dreaming ideal protein structures

A deep learning algorithm for protein structure prediction is used in reverse for de novo protein design.

Noelia Ferruz
Birte Höcker
News & Views 24 Jan 2022
Back and forth with nanopore peptide sequencing

Tagging peptides with DNA allows repeated reads via a helicase in a nanopore with reduced error rates.

Meni Wanunu
News & Views 20 Jan 2022
Podcast
- First Rounders: Ingmar Hoerr
  
  Podcast 15 Feb 2022

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Research

Review Articles
- Identification of tumor antigens with immunopeptidomics
  
  Chong et al. review how the integration of mass spectrometry with proteogenomic approaches can identify noncanonical antigens.
  
  Chloe Chong
  George Coukos
  Michal Bassani-Sternberg
  Review Article 11 Oct 2021
Brief Communications
- CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells
  
  Prime editors are delivered as ribonucleoproteins to zebrafish embryos and human primary cells.
  
  Karl Petri
  Weiting Zhang
  Jing-Ruey Joanna Yeh
  Brief Communication 29 Apr 2021
- Compact RNA editors with small Cas13 proteins
  
  Compact Cas13 proteins are used to design RNA editors that fit into a single adeno-associated virus.
  
  Soumya Kannan
  Han Altae-Tran
  Feng Zhang
  Brief Communication 30 Aug 2021
Articles
- Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice
  
  Optogenetics is applied to the entire mouse spinal cord.
  
  Claudia Kathe
  Frédéric Michoud
  Grégoire Courtine
  Article 27 Sept 2021
- Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer
  
  New tumor epitopes are discovered by ribosome profiling and immunopeptidome mass spectrometry.
  
  Tamara Ouspenskaia
  Travis Law
  Aviv Regev
  Article 18 Oct 2021
- Precise genomic deletions using paired prime editing
  
  Paired prime editing is used to precisely delete genomic sequences up to 10 kb.
  
  Junhong Choi
  Wei Chen
  Jay Shendure
  Article 14 Oct 2021
- Deletion and replacement of long genomic sequences using prime editing
  
  Prime editing is expanded to deletions and replacements of genomic sequences of up to 10 kb.
  
  Tingting Jiang
  Xiao-Ou Zhang
  Wen Xue
  
  Special:
  
  SCGE
  Article 14 Oct 2021
- Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin
  
  Single-cell mapping of heterochromatin and euchromatin using chromatin velocity defines trajectories of epigenetic modifications.
  
  Martina Tedesco
  Francesca Giannese
  Giovanni Tonon
  Article 11 Oct 2021
- Differential abundance testing on single-cell data using k-nearest neighbor graphs
  
  Milo identifies differentially abundant populations of cells in scRNA-seq data without clustering.
  
  Emma Dann
  Neil C. Henderson
  John C. Marioni
  Article 30 Sept 2021
- Multiscale and integrative single-cell Hi-C analysis with Higashi
  
  Single-cell Hi-C analysis with Higashi identifies cell-to-cell variability of 3D genome organization.
  
  Ruochi Zhang
  Tianming Zhou
  Jian Ma
  Article Open Access 11 Oct 2021
- A small and highly sensitive red/far-red optogenetic switch for applications in mammals
  
  Highly sensitive photoswitchable dimerizer enables the control of biological processes with red light in mammals.
  
  Yang Zhou
  Deqiang Kong
  Haifeng Ye
  Article 04 Oct 2021

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Amendments & Corrections

Author Correction: CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

Karl Petri
Weiting Zhang
Jing-Ruey Joanna Yeh
Author Correction 13 May 2021

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Careers & Recruitment

Career Feature
- Assessing workforce needs for the emerging CAR-T cell therapy industry
  
  The complicated and labor-intensive manufacturing of novel cell and gene therapies requires efforts to improve workforce development programs for the nascent cell therapy industry broadly, and for cell manufacturing more specifically.
  
  Linda D. Ho
  Hadassah L. Robbins
  Aaron D. Levine
  Career Feature 15 Feb 2022
- Fourth-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 15 Feb 2022
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 15 Feb 2022

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Volume 40 Issue 2, February 2022

A compact Cas13

Editorial

News

Data Page

News Feature

Correspondence

Features

Patents

News & Views

Podcast

Research

Review Articles

Brief Communications

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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