Volume 40 Issue 1, January 2022

Editorial

Insulin — the new battleground for drug pricing

Outrage over the cost of insulin is driving drug-pricing reform. Industry must do more to support patients dealing with spiraling out-of-pocket costs for biotech medicines.

Editorial 03 Jan 2022

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News

T-cell vaccines could top up immunity to COVID, as variants loom large

Peptide jabs targeting T cells could be especially useful for people with compromised immune systems, as backups for spike-based vaccines, or against Omicron and other emerging variants.

Elie Dolgin
News 13 Dec 2021
FDA go-ahead for myasthenia gravis agent

News in Brief 18 Jan 2022
Off-the-shelf, gene-edited CAR-T cells forge ahead, despite safety scare

Race to the clinic reignites for an off-the-shelf alternative to autologous CAR-T cell therapy, even as concerns over chromosomal abnormalities linger.

Cormac Sheridan
News 15 Dec 2021
Little black carbon-capture dress

News in Brief 18 Jan 2022
Synbio salvages alcohol-free beer

Lisa Melton
News 18 Jan 2022
GABA-enriched tomato is first CRISPR-edited food to enter market

Sanatech Seed’s Sicilian Rouge CRISPR-edited ‘health-promoting’ tomatoes reach consumers and may open the market to more genome-edited fruit, vegetables and even fish.

Emily Waltz
News 14 Dec 2021
Japan embraces CRISPR-edited fish

News in Brief 30 Dec 2021
Biotech news from around the world

News in Brief 18 Jan 2022
News Feature
- The PROTAC gold rush
  
  Investment in small-molecule protein degraders is surging, but their drawbacks, limitations and risks are becoming clear.
  
  Ken Garber
  News Feature 14 Dec 2021

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Correspondence

Constructive principles for gene editing oversight

Mike May
L. Val Giddings
Richard J. Roberts
Correspondence 06 Jan 2022
The DxConnect Virtual Biobank connects diagnostic researchers to clinical samples

Stefano Ongarello
Marta Fernández Suárez
Fay Betsou
Correspondence 22 Dec 2021

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World View

Expanding global access to genetic therapies

It is time to rethink intellectual property and pricing practices that prevent global access to genetic therapies.

Anne W. T. Muigai
World View 07 Jan 2022

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Features

Patents
- The characteristics of patents impacting availability of biosimilars
  
  The large number of biologic drug patents in the United States has contributed to delays in biosimilar availability.
  
  Victor L. Van de Wiele
  Reed F. Beall
  Ameet Sarpatwari
  Patents 18 Jan 2022
- Cancer diagnostics
  
  Recent patents relating to the detection, monitoring and treatment of cancer.
  
  Patents 30 Dec 2021

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News & Views

Predicting disease variants using biodiversity and machine learning

An algorithm that uses evolutionary data to predict disease variants makes a case for embracing computational evidence for clinical interpretation of genetic variation.

Claudia Arnedo-Pac
Nuria Lopez-Bigas
Ferran Muiños
News & Views 23 Dec 2021
Podcast
- First Rounders: Lita Nelsen
  
  Podcast 14 Dec 2021
- Forum: Drug delivery roundtable with Langer and Whitehead
  
  Podcast 21 Dec 2021

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Research

Review Articles
- Single-cell immunology of SARS-CoV-2 infection
  
  This Review provides an overview of existing studies using single-cell technologies to provide insights over the immune responses and molecular mechanisms at work in COVID-19.
  
  Yuan Tian
  Lindsay N. Carpp
  Raphael Gottardo
  Review Article 20 Dec 2021
Brief Communications
- Multiplexed direct detection of barcoded protein reporters on a nanopore array
  
  Reporter proteins are easily multiplexed using protein barcodes measured with nanopores.
  
  Nicolas Cardozo
  Karen Zhang
  Jeff Nivala
  Brief Communication 12 Aug 2021
Articles
- Purification of multiplex oligonucleotide libraries by synthesis and selection
  
  Accurate oligonucleotide libraries are produced by synthesis and selection.
  
  Hansol Choi
  Yeongjae Choi
  Sunghoon Kwon
  Article 29 Jul 2021
- Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph analysis (CoNGA)
  
  Integrating T cell sequences and gene expression profiles uncovers functional subsets in single-cell datasets.
  
  Stefan A. Schattgen
  Kate Guion
  Philip Bradley
  Article 23 Aug 2021
- Single-cell measurement of higher-order 3D genome organization with scSPRITE
  
  Long-range genome interactions are measured in thousands of single cells.
  
  Mary V. Arrastia
  Joanna W. Jachowicz
  Mitchell Guttman
  Article 23 Aug 2021
- Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
  
  Improved integration of spatial and single-cell transcriptomic data provides insights into mouse development.
  
  T. Lohoff
  S. Ghazanfar
  J. C. Marioni
  Article Open Access 06 Sept 2021
- Identifying transcriptional programs underlying cancer drug response with TraCe-seq
  
  Transcriptional mechanisms of drug response are identified with scRNA-seq and molecular barcoding.
  
  Matthew T. Chang
  Frances Shanahan
  Xin Ye
  Article 16 Sept 2021
- Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs delivered by adeno-associated virus
  
  A miniature CRISPR system may enable genome editing using single AAV vectors.
  
  Do Yon Kim
  Jeong Mi Lee
  Yong-Sam Kim
  Article Open Access 02 Sept 2021
- Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors
  
  Biologics are delivered by a pill that pricks the stomach wall.
  
  Alex Abramson
  Morten Revsgaard Frederiksen
  Giovanni Traverso
  Article 30 Aug 2021
Analysis
- Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19
  
  The immune cells of individuals with COVID-19 show metabolic changes.
  
  Jihoon W. Lee
  Yapeng Su
  James R. Heath
  Analysis 06 Sept 2021
- Mapping single-cell data to reference atlases by transfer learning
  
  Single-cell data are readily integrated with cell atlases using scArches.
  
  Mohammad Lotfollahi
  Mohsen Naghipourfar
  Fabian J. Theis
  Analysis Open Access 30 Aug 2021

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Amendments & Corrections

Publisher Correction: Top 20 translational researchers of 2020

Brady Huggett
Kathryn Paisner
Publisher Correction 21 Dec 2021
Publisher Correction: Sickle cell gene therapies approach watershed

Cormac Sheridan
Publisher Correction 27 Dec 2021
Publisher Correction: T_reg engineers take aim at autoimmunity

Elie Dolgin
Publisher Correction 05 Jan 2022

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Careers & Recruitment

Career Feature
- Virtual meetings promise to eliminate geographical and administrative barriers and increase accessibility, diversity and inclusivity
  
  Conference organizers must adopt a novel, comprehensive approach to ensure increased accessibility, diversity and inclusivity of post-pandemic conferences.
  
  Juncheng Wu
  Anushka Rajesh
  Serghei Mangul
  Career Feature 29 Dec 2021
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 30 Dec 2021

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Volume 40 Issue 1, January 2022

Single-cell data in context

Editorial

News

News Feature

Correspondence

World View

Features

Patents

News & Views

Podcast

Research

Review Articles

Brief Communications

Articles

Analysis

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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