Volume 39 Issue 5, May 2021

ChIP-seq of cell-free DNA

An artist's impression of what we can learn from assaying chromatin fragments released from dying cells; the whole body is reflected in a blood sample. Sadeh et al. present a method for assaying these fragments to study cell type and state in health and disease.

See Sadeh et al.

Image: Lior Friedman. Cover Design: Erin Dewalt.

Editorial

The viral arms race

To keep ahead of an increasing number of SARS-CoV-2 variants, pathogen surveillance and testing must become a joined-up global, rather than local, endeavor.

Editorial 04 May 2021

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News

Fecal microbiota potentiate checkpoint inhibitors, unleash microbiome startups

Microbiome companies are scrambling for a piece of the action as checkpoint inhibitors combined with fecal microbiome transplants enhance patient responses to immunotherapy.

Mark Zipkin
News 16 Apr 2021
First CAR-T therapy to target BCMA gets FDA nod

News in Brief 12 May 2021
Armyworm meets Friendly moth

Michael Francisco
News 12 May 2021
COVID-19 testing turns to T cells

A diagnostic test based on sequencing long-lived SARS-CoV-2–specific memory T cells provides a complement to antibody testing for determining previous exposure to SARS-CoV-2.

Cormac Sheridan
News 12 May 2021
What two US counties will tell us about COVID-19

News in Brief 12 May 2021
Barista milk: climate-friendly and still dairy

News in Brief 12 May 2021
Around the world in a month

News in Brief 12 May 2021
Data Page
- Drug pipeline 1Q21—the old and the new
  
  Laura DeFrancesco
  Data Page 12 May 2021
- 1Q21—thirst for preclinical biotechs unquenched
  
  Laura DeFrancesco
  Data Page 12 May 2021
News Feature
- Slivers of the spectrum
  
  Large-scale genomic studies are reinvigorating interest in a small group of molecularly defined autism-associated disorders and spurring renewed interest in genetic therapies.
  
  Malorye Branca
  News Feature 22 Apr 2021

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Features

Patents
- A network analysis of COVID-19 mRNA vaccine patents
  
  A preliminary network analysis highlights the complex intellectual property landscape behind mRNA-based COVID-19 vaccines.
  
  Mario Gaviria
  Burcu Kilic
  Patents 12 May 2021
- mRNA vaccines
  
  Recent patents for the composition, preparation and therapeutic use of mRNA vaccines.
  
  Patents 12 May 2021

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News & Views

Podcast
- First Rounders: Craig Mello
  
  Podcast 12 May 2021

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Research

Brief Communications
- Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus
  
  Left-handed DNA probes improve super-resolution DNA-PAINT imaging in the nucleus by reducing background.
  
  H. J. Geertsema
  G. Aimola
  H. Ewers
  Brief Communication 04 Jan 2021
Letters
- Improved metagenome binning and assembly using deep variational autoencoders
  
  Metagenomics data are resolved into their constituent genomes using a new deep learning method.
  
  Jakob Nybo Nissen
  Joachim Johansen
  Simon Rasmussen
  Letter 04 Jan 2021
- A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat
  
  Combining fungal-resistance genes into a single cassette enables the generation of highly resistant wheat lines.
  
  Ming Luo
  Liqiong Xie
  Michael Ayliffe
  Letter 04 Jan 2021
Articles
- Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice
  
  CRISPR–Cas9 eliminates herpes simplex virus both in the corneal infection site and in the viral reservoir of the trigeminal ganglia.
  
  Di Yin
  Sikai Ling
  Yujia Cai
  Article 11 Jan 2021
- CheckV assesses the quality and completeness of metagenome-assembled viral genomes
  
  The quality of viral genomes assembled from metagenome data is assessed by CheckV.
  
  Stephen Nayfach
  Antonio Pedro Camargo
  Nikos C. Kyrpides
  Article Open Access 21 Dec 2020
- ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin
  
  Circulating cell-free DNA from patients is analyzed by ChIP-seq to reconstruct gene expression in human organs and tumors.
  
  Ronen Sadeh
  Israa Sharkia
  Nir Friedman
  Article 11 Jan 2021
- Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes
  
  Clonal subpopulations in human tumors are identified from single-cell RNA-seq data.
  
  Ruli Gao
  Shanshan Bai
  Nicholas E. Navin
  Article 18 Jan 2021
- Volumetric live cell imaging with three-dimensional parallelized RESOLFT microscopy
  
  A super-resolution microscope images live cells in 3D with high speed, large fields of view and minimal photodamage.
  
  Andreas Bodén
  Francesca Pennacchietti
  Ilaria Testa
  Article 11 Jan 2021
Analysis
- Quantifying the effect of experimental perturbations at single-cell resolution
  
  Matched treatment and control single-cell RNA sequencing samples are more accurately compared at the single-cell level.
  
  Daniel B. Burkhardt
  Jay S. Stanley III
  Smita Krishnaswamy
  Analysis 08 Feb 2021
Resources
- Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries
  
  An improved workflow enables a 42-fold higher throughput of activity-based protein profiling.
  
  Miljan Kuljanin
  Dylan C. Mitchell
  Steven P. Gygi
  Resource 04 Jan 2021

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Amendments & Corrections

Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Ronen Sadeh
Israa Sharkia
Nir Friedman
Author Correction 21 Jan 2021
Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Ronen Sadeh
Israa Sharkia
Nir Friedman
Author Correction 01 Mar 2021

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Careers & Recruitment

Career Feature
- First-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 12 May 2021
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 12 May 2021

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Volume 39 Issue 5, May 2021

ChIP-seq of cell-free DNA

Editorial

News

Data Page

News Feature

Features

Patents

News & Views

Podcast

Research

Brief Communications

Letters

Articles

Analysis

Resources

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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