Volume 38

  • No. 12 December 2020

    RNA velocity fully solved

    Visualization of cellular dynamics during pancreatic endocrinogenesis based on RNA velocity analysis. Bergen et al. present scVelo, a method that improves RNA velocity analysis by capturing transient cell states and providing a more detailed view of cellular transcriptional dynamics.

    See Bergen et al.

  • No. 11 November 2020

    Live births from bioengineered wombs

    A study in this issue of Nature Biotechnology reports the use of bioengineered scaffolds to repair injured uteri and enable live births in rabbits. This image shows one of the subjects, a New Zealand white, with her kit.

    See Magalhaes et al.

  • No. 10 October 2020

    SARS-CoV-2 detection

    In this issue, several groups report their findings on the development of methods to detect SARS-CoV-2 in patients and in the community, and benchmark assays to detect SARS-CoV-2-specific antibodies.

    See Nachtigall et al., Peccia et al. and Whitman et al.

  • No. 9 September 2020

    Soft electronics morph as tissues grow

    Zhenan Bao and colleagues design and fabricate multilayered electronics that adapt to growing nerves, allowing chronic electrical stimulation during the fastest growth period in rats. The approach opens the door to electronic medicine that adapts to growth in children and adolescents.

    See Y. Liu et al.

  • No. 8 August 2020

    CAR macrophages

    A scanning electron micrograph of a macrophage (top) and cancer cells. In this issue, Klichinsky et al. engineer macrophages with human chimeric antigen receptors, directing their phagocytic activity against tumors.

    See Klichinsky et al.

  • No. 7 July 2020

    Focus on CRISPR tools and therapies

    CRISPR-based genome editing has become a mainstay of experimental biology and is now maturing into a tool for therapeutic applications. Constant progress is being made in designing ever more sophisticated protein machines to catalyze desired changes with high efficiency and specificity, and in the methods to deliver the macromolecules involved to the tissues and cells. Many of the more recent advances have not entered clinical development yet, but will ultimately help therapeutic genome editing fulfill its full potential. Illustration of the structure of the CRISPR–Cas9 gene-editing complex, showing the guide RNA template (red), the Cas9 protein (blue) and the double strand of DNA (gray).

    See Focus on CRISPR tools and therapies

  • No. 6 June 2020

    Cas13d guide design principles

    Optimizing guide RNA design for Cas13. With data from massively parallel screens, Wessels et al. develop computational models to identify optimal guide RNAs for the RNA-targeting CRISPR enzyme Cas13d.

    See Wessels et al.

  • No. 5 May 2020

    Western corn rootworm biocontrol

    An adult western corn rootworm, one of the most devastating pests of maize. Machado et al. use experimental evolution of bacterial symbionts of a nematode pathogen of western corn rootworm larvae to improve the insect-killing efficacy of their nematode host.

    See Machado et al.

  • No. 4 April 2020

    Sex-sorting machine for mosquito control

    Aedes aegytpi mosquitoes are imaged in a sex-sorting device. Crawford et al. describe the production of accurately sorted sterile male mosquitoes and their deployment in a mosquito-eradication trial.

    See Crawford et al.

  • No. 3 March 2020

    Uniform nanoparticle vaccines

    Precise loading of diverse peptides for vaccination is enabled by a strategy for peptide–TLR7/8 conjugate self-assembly of uniform nanoparticles. The approach is compatible with the development of personalized strategies, such as cancer vaccines targeting patient-specific neoepitopes.

    See Lynn et al.

  • No. 2 February 2020

    Engineering plants for vertical farms

    Compact, early-fruiting ‘triple-determinate’ tomato and groundcherry plants suitable for vertical farming are produced using genome editing.

    See Kwon et al.

  • No. 1 January 2020

    Editing dicots without tissue culture

    Developmental regulators are used to reprogram edited dicot plant cells into meristematic cells that grow into plants without tissue culture.

    See Maher et al.