Volume 38 Issue 6, June 2020

Editorial

The COVID-19 testing debacle

Insufficient SARS-CoV-2 testing has left many nations flying blind as they reopen their economies. Without adequate testing, new infections could outrun control measures.

Editorial 03 Jun 2020

Advertisement

Top of page ⤴

News

Convalescent serum lines up as first-choice treatment for coronavirus

Antibodies from blood donated by people who recovered from the illness and hyper-immunoglobulins are becoming treatments of choice for COVID-19, with recombinant polyclonal antibody approaches to follow.

Cormac Sheridan
News 01 May 2020
Genomic search for COVID-19 severity clues

News in Brief 09 Jun 2020
Around the world in a month

News in Brief 09 Jun 2020
Drug researchers pursue new lines of attack against COVID-19

Learning which proteins in the body are co-opted by coronavirus may uncover new drug targets and enable a better understanding of the body’s responses to infection.

Charlotte Harrison
News 15 May 2020
Dyno advances AI-powered gene therapy

News in Brief 09 Jun 2020
FDA approves first RET inhibitor

News in Brief 09 Jun 2020
Biotech companies prepare for COVID-19 downturn

Biopharmaceutical companies are awash with more cash than at any time in the sector’s history. But they are scrambling to prepare for the drought of a COVID-19-related recession.

Melanie Senior
News 15 May 2020
News Feature
- Closing the recycling circle
  
  Capturing the value back from plastic waste has been the holy grail of recyclers. Biotechnology is taking us closer to a solution.
  
  Laura DeFrancesco
  News Feature 21 May 2020

Top of page ⤴

Correspondence

Overcoming barriers to early disease intervention

H. Hugo Caicedo
Daniel A. Hashimoto
Gary P. Pisano
Correspondence 22 May 2020
Diagnostics and the coronavirus: don’t let the standards slip

Mark Page
Neil Almond
Christian K. Schneider
Correspondence 22 May 2020
Visualizing and interpreting cancer genomics data via the Xena platform

Mary J. Goldman
Brian Craft
David Haussler
Correspondence 22 May 2020
The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data

Joo Guan Yeo
Martin Wasser
Salvatore Albani
Correspondence 21 May 2020
PICRUSt2 for prediction of metagenome functions

Gavin M. Douglas
Vincent J. Maffei
Morgan G. I. Langille
Correspondence 01 Jun 2020

Top of page ⤴

Features

Patents
- 3D and 4D bioprinted human model patenting and the future of drug development
  
  Bioprinted 3D and 4D tissues and organs are expected to revolutionize the biomedical field, eliminating the need for laboratory animals, but little is known about the future impacts of these technologies on drug development.
  
  Fabio Mota
  Luiza Braga
  Bernardo Cabral
  Patents 09 Jun 2020
- Coronaviruses
  
  Recent patents related to vaccines and methods of treatment of coronaviruses.
  
  Patents 09 Jun 2020

Top of page ⤴

News & Views

Single-cell RNA sequencing at isoform resolution

SMART-seq3 reconstructs the full-length transcripts of single cells with high sensitivity.

Evan Z. Macosko
News & Views 19 May 2020
Podcast
- Forum: First human trial of engineered T cells
  
  Podcast 19 May 2020
- Forum: Worms and gut microbes team up to kill corn pest
  
  Podcast 19 May 2020
- First rounders: Alexis Borisy
  
  Podcast 21 May 2020

Top of page ⤴

Research

Letters
- Complete, closed bacterial genomes from microbiomes using nanopore sequencing
  
  Nanopore-metagenomics workflow enables assembly of complete, closed bacterial genomes from human stool samples.
  
  Eli L. Moss
  Dylan G. Maghini
  Ami S. Bhatt
  Letter Open Access 10 Feb 2020
- Single-cell RNA counting at allele and isoform resolution using Smart-seq3
  
  Smart-seq3 enables isoform- and allele-specific reconstruction of RNA molecules.
  
  Michael Hagemann-Jensen
  Christoph Ziegenhain
  Rickard Sandberg
  Letter 04 May 2020
- High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics
  
  Millions of primary IgG-secreting cells from mouse and human are characterized for activity and antibody sequence at the single-cell level.
  
  Annabelle Gérard
  Adam Woolfe
  Colin Brenan
  Letter 30 Mar 2020
- Massively parallel Cas13 screens reveal principles for guide RNA design
  
  Design of optimal guide RNAs for Cas13d-mediated RNA knockdown is enabled by computational modeling of large-scale screening data.
  
  Hans-Hermann Wessels
  Alejandro Méndez-Mancilla
  Neville E. Sanjana
  Letter 16 Mar 2020
Articles
- ChromID identifies the protein interactome at chromatin marks
  
  The protein complexes associated with specific chromatin marks in living cells are identified using engineered binding proteins.
  
  Rodrigo Villaseñor
  Ramon Pfaendler
  Tuncay Baubec
  Article 02 Mar 2020
Analysis
- Systematic comparison of single-cell and single-nucleus RNA-sequencing methods
  
  Seven methods for single-cell RNA sequencing are benchmarked on cell lines, primary cells and mouse cortex.
  
  Jiarui Ding
  Xian Adiconis
  Joshua Z. Levin
  Analysis 06 Apr 2020
- Benchmarking single-cell RNA-sequencing protocols for cell atlas projects
  
  A multicenter study compares 13 commonly used single-cell RNA-seq protocols.
  
  Elisabetta Mereu
  Atefeh Lafzi
  Holger Heyn
  Analysis 06 Apr 2020

Top of page ⤴

Amendments & Corrections

Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

Jiarui Ding
Xian Adiconis
Joshua Z. Levin
Author Correction 27 Apr 2020
Author Correction: High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Annabelle Gérard
Adam Woolfe
Colin Brenan
Author Correction 22 May 2020
Publisher Correction: ChromID identifies the protein interactome at chromatin marks

Rodrigo Villaseñor
Ramon Pfaendler
Tuncay Baubec
Publisher Correction 17 Mar 2020
Publisher Correction: The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data

Joo Guan Yeo
Martin Wasser
Salvatore Albani
Publisher Correction 28 May 2020

Top of page ⤴

Careers & Recruitment

Career Feature
- Translating academic careers into industry healthcare professions
  
  Though academic institutions have contributed enormously to the remarkable growth in the healthcare industry, a key limiting resource for this continued growth is the creation of career opportunities for doctoral graduates.
  
  Sinje Gehr
  Craig C. Garner
  Karin N. Kleinhans
  Career Feature 09 Jun 2020
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 09 Jun 2020

Top of page ⤴

Volume 38 Issue 6, June 2020

Cas13d guide design principles

Editorial

News

News Feature

Correspondence

Features

Patents

News & Views

Podcast

Research

Letters

Articles

Analysis

Amendments & Corrections

Careers & Recruitment

Career Feature

People

Search

Quick links