Volume 38 Issue 4, April 2020

Editorial

Open for outbreaks

In the onslaught of the COVID-19 pandemic, the open sharing of materials, information and data is gaining increasing importance in biotech.

Editorial 03 Apr 2020

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News

Coronavirus puts drug repurposing on the fast track

Existing antivirals and knowledge gained from the SARS and MERS outbreaks gain traction as the fastest route to fight the current coronavirus epidemic.

Charlotte Harrison
News 27 Feb 2020
First CRISPR therapy dosed

News in Brief 07 Apr 2020
Coronavirus and the race to distribute reliable diagnostics

International teams worked at speed to make tests for the virus available in record time.

Cormac Sheridan
News 19 Feb 2020
Second RNAi drug approved

News in Brief 07 Apr 2020
IGF-1R drugs travel from cancer cradle to Graves’

One of the most intensively investigated molecular targets in oncology proves its therapeutic worth for thyroid eye disease.

Elie Dolgin
News 07 Apr 2020
Around the world in a month

News in Brief 07 Apr 2020
Forty Seven to Gilead: “Eat me”

News in Brief 07 Apr 2020
γδ T cells bring unconventional cancer-targeting to the clinic — again

A growing number of companies seek to unleash these unusual T cells against cancer.

Ken Garber
News 07 Apr 2020
News Feature
- Out of your skin
  
  Long neglected compared with the gut microbiome, skin microbes are beginning to yield their secrets in health and disease, spurring a new cadre of biotech startups.
  
  Charlie Schmidt
  News Feature 17 Mar 2020

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Correspondence

What would responsible remedial human germline editing look like?

Eli Y. Adashi
I. Glenn Cohen
Correspondence 25 Mar 2020

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Comment

The case for biotech on Mars

The stepwise application of biotechnology will be instrumental to addressing four key challenges of Martian settlement.

Shannon N. Nangle
Mikhail Y. Wolfson
Marika Ziesack
Comment 01 Apr 2020

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Features

Europe’s biotech renaissance

European biotech companies continued to raise unprecedented amounts of capital last year. Can they survive what are likely to be leaner times ahead?

Melanie Senior

Nature Outlook:

The Spinoff Prize 2020
Feature 07 Apr 2020
Patents
- Antimicrobials
  
  Recent patents related to new antimicrobial materials and methods of imparting antimicrobial activity to an article or product.
  
  Patents 07 Apr 2020

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News & Views

Predicting antidepressant response by electroencephalography

Patients who respond to an antidepressant are identified by retrospective analysis of their brain waves.

Christoph M. Michel
Alvaro Pascual-Leone
News & Views 17 Mar 2020
Podcast
- Forum: Repurposing viral immunity to fight cancer
  
  Podcast 07 Apr 2020

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Research

Letters
- Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy
  
  Anti-tumor activity of cytomegalovirus (CMV)-specific CD8 T cells is achieved by antibody-mediated delivery of CMV epitopes.
  
  David G. Millar
  Rakesh R. Ramjiawan
  Mark Cobbold
  Letter 10 Feb 2020
- A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
  
  The activity of CAR-T cells is reversibly halted with a small-molecule drug.
  
  Greta Giordano-Attianese
  Pablo Gainza
  Bruno E. Correia
  Letter 03 Feb 2020
- Targeted nanopore sequencing with Cas9-guided adapter ligation
  
  Point mutations, structural variants and DNA methylation at target loci are assessed by nanopore sequencing.
  
  Timothy Gilpatrick
  Isac Lee
  Winston Timp
  Letter 10 Feb 2020
Articles
- An electroencephalographic signature predicts antidepressant response in major depression
  
  The efficacy of an antidepressant is predicted from an EEG signature.
  
  Wei Wu
  Yu Zhang
  Amit Etkin
  Article 10 Feb 2020
- Interleukin-23 engineering improves CAR T cell function in solid tumors
  
  The efficacy of chimeric antigen receptor (CAR) T cells in solid tumor models is enhanced by interleukin-23 engineering.
  
  Xingcong Ma
  Peishun Shou
  Yang Xu
  Article 03 Feb 2020
- Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
  
  Generation of pancreatic β cells from stem cells is enhanced by manipulating the cytoskeleton.
  
  Nathaniel J. Hogrebe
  Punn Augsornworawat
  Jeffrey R. Millman
  
  Collection:
  
  Stem cells from development to the clinic
  Article 24 Feb 2020
- Continuous evolution of SpCas9 variants compatible with non-G PAMs
  
  PAM sequences without G bases can be edited with SpCas9 variants that were continuously evolved in the laboratory.
  
  Shannon M. Miller
  Tina Wang
  David R. Liu
  
  Special:
  
  SCGE
  Article 10 Feb 2020
- Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations
  
  Mosquitoes are nearly eradicated in three suburbs of California using accurately sorted sterile male mosquitoes.
  
  Jacob E. Crawford
  David W. Clarke
  Bradley J. White
  Article 06 Apr 2020
Resources
- Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring
  
  Improved methods to reconstruct global kinase-signaling networks from phosphoproteomics data are applied in cancer cells.
  
  Maruan Hijazi
  Ryan Smith
  Pedro R. Cutillas
  Resource 20 Jan 2020

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Amendments & Corrections

Author Correction: A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Greta Giordano-Attianese
Pablo Gainza
Bruno E. Correia
Author Correction 03 Mar 2020
Author Correction: Using GlycoDelete to produce proteins lacking plant-specific N-glycan modification in seeds

Robin Piron
Francis Santens
Nico Callewaert
Author Correction 05 Mar 2020
Author Correction: Template plasmid integration in germline genome-edited cattle

Alexis L. Norris
Stella S. Lee
Heather A. Lombardi
Author Correction 05 Mar 2020
Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing

Christian Lieven
Moritz E. Beber
Cheng Zhang
Publisher Correction Open Access 19 Mar 2020

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Careers & Recruitment

People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 07 Apr 2020

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Volume 38 Issue 4, April 2020

Sex-sorting machine for mosquito control

Editorial

News

News Feature

Correspondence

Comment

Features

Patents

News & Views

Podcast

Research

Letters

Articles

Resources

Amendments & Corrections

Careers & Recruitment

People

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