Volume 38 Issue 3, March 2020

Volume 38 Issue 3

Uniform nanoparticle vaccines

Precise loading of diverse peptides for vaccination is enabled by a strategy for peptide–TLR7/8 conjugate self-assembly of uniform nanoparticles. The approach is compatible with the development of personalized strategies, such as cancer vaccines targeting patient-specific neoepitopes.

See Lynn et al.

Image: Medmovie (www.medmovie.com ). Cover Design: Erin Dewalt.

Editorial

  • Editorial |

    In the post-Brexit era, Britain must rapidly harmonize national and European law, secure unfettered access to global talent and address funding shortfalls to ensure continued leadership in the life sciences.

News

Bioentrepreneur

    Building a Business

  • Building a Business |

    Some practical advice on how to protect research that you are seeking to commercialize.

    • Sadhana Chitale
    • , Colm Lawler
    •  & Scott Macfarlane

Correspondence

  • Correspondence | | Open Access

    • Christian Lieven
    • , Moritz E. Beber
    • , Brett G. Olivier
    • , Frank T. Bergmann
    • , Meric Ataman
    • , Parizad Babaei
    • , Jennifer A. Bartell
    • , Lars M. Blank
    • , Siddharth Chauhan
    • , Kevin Correia
    • , Christian Diener
    • , Andreas Dräger
    • , Birgitta E. Ebert
    • , Janaka N. Edirisinghe
    • , José P. Faria
    • , Adam M. Feist
    • , Georgios Fengos
    • , Ronan M. T. Fleming
    • , Beatriz García-Jiménez
    • , Vassily Hatzimanikatis
    • , Wout van Helvoirt
    • , Christopher S. Henry
    • , Henning Hermjakob
    • , Markus J. Herrgård
    • , Ali Kaafarani
    • , Hyun Uk Kim
    • , Zachary King
    • , Steffen Klamt
    • , Edda Klipp
    • , Jasper J. Koehorst
    • , Matthias König
    • , Meiyappan Lakshmanan
    • , Dong-Yup Lee
    • , Sang Yup Lee
    • , Sunjae Lee
    • , Nathan E. Lewis
    • , Filipe Liu
    • , Hongwu Ma
    • , Daniel Machado
    • , Radhakrishnan Mahadevan
    • , Paulo Maia
    • , Adil Mardinoglu
    • , Gregory L. Medlock
    • , Jonathan M. Monk
    • , Jens Nielsen
    • , Lars Keld Nielsen
    • , Juan Nogales
    • , Intawat Nookaew
    • , Bernhard O. Palsson
    • , Jason A. Papin
    • , Kiran R. Patil
    • , Mark Poolman
    • , Nathan D. Price
    • , Osbaldo Resendis-Antonio
    • , Anne Richelle
    • , Isabel Rocha
    • , Benjamín J. Sánchez
    • , Peter J. Schaap
    • , Rahuman S. Malik Sheriff
    • , Saeed Shoaie
    • , Nikolaus Sonnenschein
    • , Bas Teusink
    • , Paulo Vilaça
    • , Jon Olav Vik
    • , Judith A. H. Wodke
    • , Joana C. Xavier
    • , Qianqian Yuan
    • , Maksim Zakhartsev
    •  & Cheng Zhang

Features

News & Views

Research

    Brief Communications

  • Brief Communication | | Open Access

    Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

    • Sergei Yakneen
    • , Sebastian M. Waszak
    • , Sergei Yakneen
    • , Brice Aminou
    • , Javier Bartolome
    • , Keith A. Boroevich
    • , Rich Boyce
    • , Angela N. Brooks
    • , Alex Buchanan
    • , Ivo Buchhalter
    • , Adam P. Butler
    • , Niall J. Byrne
    • , Andy Cafferkey
    • , Peter J. Campbell
    • , Zhaohong Chen
    • , Sunghoon Cho
    • , Wan Choi
    • , Peter Clapham
    • , Brandi N. Davis-Dusenbery
    • , Francisco M. De La Vega
    • , Jonas Demeulemeester
    • , Michelle T. Dow
    • , Lewis Jonathan Dursi
    • , Juergen Eils
    • , Roland Eils
    • , Kyle Ellrott
    • , Claudiu Farcas
    • , Francesco Favero
    • , Nodirjon Fayzullaev
    • , Vincent Ferretti
    • , Paul Flicek
    • , Nuno A. Fonseca
    • , Josep Ll. Gelpi
    • , Gad Getz
    • , Bob Gibson
    • , Robert L. Grossman
    • , Olivier Harismendy
    • , Allison P. Heath
    • , Michael C. Heinold
    • , Julian M. Hess
    • , Oliver Hofmann
    • , Jongwhi H. Hong
    • , Thomas J. Hudson
    • , Barbara Hutter
    • , Carolyn M. Hutter
    • , Daniel Hübschmann
    • , Seiya Imoto
    • , Sinisa Ivkovic
    • , Seung-Hyup Jeon
    • , Wei Jiao
    • , Jongsun Jung
    • , Rolf Kabbe
    • , Andre Kahles
    • , Jules N. A. Kerssemakers
    • , Hyung-Lae Kim
    • , Hyunghwan Kim
    • , Jihoon Kim
    • , Youngwook Kim
    • , Kortine Kleinheinz
    • , Michael Koscher
    • , Antonios Koures
    • , Milena Kovacevic
    • , Chris Lawerenz
    • , Ignaty Leshchiner
    • , Jia Liu
    • , Dimitri Livitz
    • , George L. Mihaiescu
    • , Sanja Mijalkovic
    • , Ana Mijalkovic Lazic
    • , Satoru Miyano
    • , Naoki Miyoshi
    • , Hardeep K. Nahal-Bose
    • , Hidewaki Nakagawa
    • , Mia Nastic
    • , Steven J. Newhouse
    • , Jonathan Nicholson
    • , Brian D. O’Connor
    • , David Ocana
    • , Kazuhiro Ohi
    • , Lucila Ohno-Machado
    • , Larsson Omberg
    • , B. F Francis Ouellette
    • , Nagarajan Paramasivam
    • , Marc D. Perry
    • , Todd D. Pihl
    • , Manuel Prinz
    • , Montserrat Puiggròs
    • , Petar Radovic
    • , Keiran M. Raine
    • , Esther Rheinbay
    • , Mara Rosenberg
    • , Romina Royo
    • , Gunnar Rätsch
    • , Gordon Saksena
    • , Matthias Schlesner
    • , Solomon I. Shorser
    • , Charles Short
    • , Heidi J. Sofia
    • , Jonathan Spring
    • , Lincoln D. Stein
    • , Adam J. Struck
    • , Grace Tiao
    • , Nebojsa Tijanic
    • , David Torrents
    • , Peter Van Loo
    • , Miguel Vazquez
    • , David Vicente
    • , Jeremiah A. Wala
    • , Zhining Wang
    • , Sebastian M. Waszak
    • , Joachim Weischenfeldt
    • , Johannes Werner
    • , Ashley Williams
    • , Youngchoon Woo
    • , Adam J. Wright
    • , Qian Xiang
    • , Liming Yang
    • , Denis Yuen
    • , Christina K. Yung
    • , Junjun Zhang
    • , Jan O. Korbel
    • , Michael Gertz
    •  & Jan O. Korbel
  • Letters

  • Letter |

    Pig embryos with a human endothelium are generated through blastocyst complementation using human induced pluripotent stem cells.

    • Satyabrata Das
    • , Naoko Koyano-Nakagawa
    • , Ohad Gafni
    • , Geunho Maeng
    • , Bhairab N. Singh
    • , Tara Rasmussen
    • , Xiaoyan Pan
    • , Kyung-Dal Choi
    • , Daniel Mickelson
    • , Wuming Gong
    • , Pruthvi Pota
    • , Cyprian V. Weaver
    • , Stefan Kren
    • , Jacob H. Hanna
    • , Demetris Yannopoulos
    • , Mary G. Garry
    •  & Daniel J. Garry
  • Letter |

    The targets of small-molecule drugs are detected in tissue and blood using thermal proteome assays.

    • Jessica Perrin
    • , Thilo Werner
    • , Nils Kurzawa
    • , Anna Rutkowska
    • , Dorothee D. Childs
    • , Mathias Kalxdorf
    • , Daniel Poeckel
    • , Eugenia Stonehouse
    • , Katrin Strohmer
    • , Bianca Heller
    • , Douglas W. Thomson
    • , Jana Krause
    • , Isabelle Becher
    • , H. Christian Eberl
    • , Johanna Vappiani
    • , Daniel C. Sevin
    • , Christina E. Rau
    • , Holger Franken
    • , Wolfgang Huber
    • , Maria Faelth-Savitski
    • , Mikhail M. Savitski
    • , Marcus Bantscheff
    •  & Giovanna Bergamini
  • Articles

  • Article |

    Cancer vaccines that self-assemble into uniform nanoparticles improve tumor clearance.

    • Geoffrey M. Lynn
    • , Christine Sedlik
    • , Faezzah Baharom
    • , Yaling Zhu
    • , Ramiro A. Ramirez-Valdez
    • , Vincent L. Coble
    • , Kennedy Tobin
    • , Sarah R. Nichols
    • , Yaakov Itzkowitz
    • , Neeha Zaidi
    • , Joshua M. Gammon
    • , Nicolas J. Blobel
    • , Jordan Denizeau
    • , Philippe de la Rochere
    • , Brian J. Francica
    • , Brennan Decker
    • , Mateusz Maciejewski
    • , Justin Cheung
    • , Hidehiro Yamane
    • , Margery G. Smelkinson
    • , Joseph R. Francica
    • , Richard Laga
    • , Joshua D. Bernstock
    • , Leonard W. Seymour
    • , Charles G. Drake
    • , Christopher M. Jewell
    • , Olivier Lantz
    • , Eliane Piaggio
    • , Andrew S. Ishizuka
    •  & Robert A. Seder
  • Article |

    Complex structural variations in single cells are detected by integrating read depth, template strand and haplotype phase information.

    • Ashley D. Sanders
    • , Sascha Meiers
    • , Maryam Ghareghani
    • , David Porubsky
    • , Hyobin Jeong
    • , M. Alexandra C. C. van Vliet
    • , Tobias Rausch
    • , Paulina Richter-Pechańska
    • , Joachim B. Kunz
    • , Silvia Jenni
    • , Davide Bolognini
    • , Gabriel M. C. Longo
    • , Benjamin Raeder
    • , Venla Kinanen
    • , Jürgen Zimmermann
    • , Vladimir Benes
    • , Martin Schrappe
    • , Balca R. Mardin
    • , Andreas E. Kulozik
    • , Beat Bornhauser
    • , Jean-Pierre Bourquin
    • , Tobias Marschall
    •  & Jan O. Korbel
  • Resources

  • Resource |

    Phosphorylation sites are ranked for functional relevance using a comprehensive, high-quality human phosphoproteome.

    • David Ochoa
    • , Andrew F. Jarnuczak
    • , Cristina Viéitez
    • , Maja Gehre
    • , Margaret Soucheray
    • , André Mateus
    • , Askar A. Kleefeldt
    • , Anthony Hill
    • , Luz Garcia-Alonso
    • , Frank Stein
    • , Nevan J. Krogan
    • , Mikhail M. Savitski
    • , Danielle L. Swaney
    • , Juan A. Vizcaíno
    • , Kyung-Min Noh
    •  & Pedro Beltrao

Amendments & Corrections

Careers & Recruitment

    People

  • People |

    Recent moves of note in and around the biotech and pharma industries.