Volume 38 Issue 3, 1 March 2020

Uniform nanoparticle vaccines

Precise loading of diverse peptides for vaccination is enabled by a strategy for peptide–TLR7/8 conjugate self-assembly of uniform nanoparticles. The approach is compatible with the development of personalized strategies, such as cancer vaccines targeting patient-specific neoepitopes.

See Lynn et al.

Image: Medmovie (www.medmovie.com ). Cover Design: Erin Dewalt.

Editorial

Making the best of Brexit

In the post-Brexit era, Britain must rapidly harmonize national and European law, secure unfettered access to global talent and address funding shortfalls to ensure continued leadership in the life sciences.

Editorial 09 Mar 2020

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News

Huntington’s antisense drug marches into clinic

Prospects for agents aimed at stopping neuronal loss brighten, driven by new mechanistic understanding.

Cormac Sheridan
News 09 Mar 2020
First Rounders Podcast
- First Rounders: Bassil Dahiyat
  
  First Rounders Podcast 09 Mar 2020
FDA dictates on gene therapy sameness

News in Brief 09 Mar 2020
Go-ahead for first peanut allergy drug

News in Brief 09 Mar 2020
Single-cell RNA-seq analysis software providers scramble to offer solutions

A raft of tools have sprung up to help biologists work through the single-cell transcriptomic bottleneck, but integration remains elusive.

Michael Eisenstein
News 09 Mar 2020
BIO’s bias report

News in Brief 09 Mar 2020
Around the world in a month

News in Brief 09 Mar 2020
News Feature
- Brain’s drain
  
  Lymphatics in the central nervous system are attracting both controversy and drug hunters in search of therapeutic targets for a host of diseases.
  
  Elie Dolgin
  News Feature 17 Feb 2020

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Bioentrepreneur

Building a Business
- Understanding the basics of patenting
  
  Some practical advice on how to protect research that you are seeking to commercialize.
  
  Sadhana Chitale
  Colm Lawler
  Scott Macfarlane
  
  Nature Outlook:
  
  The Spinoff Prize 2021
  Building a Business 04 Mar 2020

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Correspondence

To publish or not to publish

Françoise Baylis
Correspondence 13 Feb 2020
MEMOTE for standardized genome-scale metabolic model testing

Christian Lieven
Moritz E. Beber
Cheng Zhang
Correspondence 02 Mar 2020
The nf-core framework for community-curated bioinformatics pipelines

Philip A. Ewels
Alexander Peltzer
Sven Nahnsen
Correspondence 13 Feb 2020

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Features

Patents
- One year after Vanda, are diagnostics patents transforming into methods of treatment to overcome Mayo-based rejections?
  
  What impact have Mayo and Vanda had for applicants attempting to obtain patent protection for inventions involving methods of diagnosis and methods of treatment?
  
  Mateo Aboy
  Cristina Crespo
  Timo Minssen
  Patents 09 Mar 2020
- Neuroengineering
  
  Recent patents related to methods of transcranial magnetic and electrostimulation.
  
  Patents 09 Mar 2020

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News & Views

Deciphering the human phosphoproteome

Machine learning provides a functional score for ~120,000 human phosphorylation sites.

Giulia Franciosa
Ana Martinez-Val
Jesper V. Olsen
News & Views 13 Feb 2020
Podcast
- Forum: Molecular mapping of tumor heterogeneity
  
  Podcast 09 Mar 2020

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Research

Brief Communications
- Butler enables rapid cloud-based analysis of thousands of human genomes
  
  Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.
  
  Sergei Yakneen
  Sebastian M. Waszak
  Christian von Mering
  
  Special:
  
  Pan-Cancer Analysis of Whole Genomes
  Brief Communication Open Access 05 Feb 2020
- Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells
  
  Mid-infrared optoacoustic microscopy enables label-free, bond-selective imaging in living cells
  
  Miguel A. Pleitez
  Asrar Ali Khan
  Vasilis Ntziachristos
  Brief Communication 23 Dec 2019
Letters
- Generation of human endothelium in pig embryos deficient in ETV2
  
  Pig embryos with a human endothelium are generated through blastocyst complementation using human induced pluripotent stem cells.
  
  Satyabrata Das
  Naoko Koyano-Nakagawa
  Daniel J. Garry
  
  Collection:
  
  Stem cells from development to the clinic
  Letter 24 Feb 2020
- Identifying drug targets in tissues and whole blood with thermal-shift profiling
  
  The targets of small-molecule drugs are detected in tissue and blood using thermal proteome assays.
  
  Jessica Perrin
  Thilo Werner
  Giovanna Bergamini
  Letter 20 Jan 2020
- An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD⁺ imbalance
  
  Intracellular redox defects are treated with an extracellular chimeric enzyme.
  
  Anupam Patgiri
  Owen S. Skinner
  Vamsi K. Mootha
  Letter 13 Jan 2020
- Accurate detection of mosaic variants in sequencing data without matched controls
  
  MosaicForecast detects mosaic single-nucleotide variants and indels in human samples.
  
  Yanmei Dou
  Minseok Kwon
  Peter J. Park
  Letter 06 Jan 2020
Articles
- Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens
  
  Cancer vaccines that self-assemble into uniform nanoparticles improve tumor clearance.
  
  Geoffrey M. Lynn
  Christine Sedlik
  Robert A. Seder
  
  Milestone:
  
  Nature Milestones in Vaccines
  Article 13 Jan 2020
- Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
  
  Combining single-cell RNA-seq data and microarray-based spatial transcriptomics maps the location of different cell types and cell states in pancreatic tumors.
  
  Reuben Moncada
  Dalia Barkley
  Itai Yanai
  Article 13 Jan 2020
- Single-cell analysis of structural variations and complex rearrangements with tri-channel processing
  
  Complex structural variations in single cells are detected by integrating read depth, template strand and haplotype phase information.
  
  Ashley D. Sanders
  Sascha Meiers
  Jan O. Korbel
  Article 23 Dec 2019
- Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
  
  Gene expression is precisely modulated with CRISPR interference and mismatched guide RNAs.
  
  Marco Jost
  Daniel A. Santos
  Jonathan S. Weissman
  Article 13 Jan 2020
Resources
- The functional landscape of the human phosphoproteome
  
  Phosphorylation sites are ranked for functional relevance using a comprehensive, high-quality human phosphoproteome.
  
  David Ochoa
  Andrew F. Jarnuczak
  Pedro Beltrao
  Resource 09 Dec 2019

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Amendments & Corrections

Author Correction: Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells

Daniel Ramsköld
Shujun Luo
Rickard Sandberg
Author Correction 03 Feb 2020
Publisher Correction: OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data

Hannes L. Röst
George Rosenberger
Ruedi Aebersold
Publisher Correction 24 Feb 2020
Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Luc Baeyens
Marie Lemper
Harry Heimberg
Retraction 17 Feb 2020

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Careers & Recruitment

People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 09 Mar 2020

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Volume 38 Issue 3, 1 March 2020

Uniform nanoparticle vaccines

Editorial

News

First Rounders Podcast

News Feature

Bioentrepreneur

Building a Business

Correspondence

Features

Patents

News & Views

Podcast

Research

Brief Communications

Letters

Articles

Resources

Amendments & Corrections

Careers & Recruitment

People

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