Volume 38 Issue 2, February 2020

Editorial

Course correction

The US Food and Drug Administration is sticking to its plan to carry out mandatory premarket review of all gene-edited livestock, irrespective of trait risk. It should rethink.

Editorial 07 Feb 2020

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News

Cancer–neuronal crosstalk and the startups working to silence it

Investors back ‘cancer neuroscience’ outfits as the field breaks out from academia.

Elie Dolgin
News 07 Feb 2020
Illumina, PacBio deal dead

News in Brief 07 Feb 2020
Digital drug fortunes falter

News in Brief 07 Feb 2020
Statin alternative awaits go-ahead

News in Brief 07 Feb 2020
Drugmakers turn sights on scarred lungs

A ‘master regulator’ of fibrosis, pentraxin, is in drugmakers’ sights, but drivers and mechanisms of the resulting remorseless and fatal lung disease remain unsolved.

Cormac Sheridan
News 07 Feb 2020
Around the world in a month

News in Brief 07 Feb 2020
First Rounders Podcast
- First Rounders: Greg Verdine
  
  First Rounders Podcast 07 Feb 2020
Data Page
- 2019 — steady as she goes
  
  Laura DeFrancesco
  Data Page 07 Feb 2020
- Drug pipeline 4Q19
  
  Laura DeFrancesco
  Data Page 07 Feb 2020
News Feature
- Fresh from the biotech pipeline—2019
  
  The biopharmaceutical industry’s positive regulatory momentum carried on through 2019, despite an early-year government shutdown, a data manipulation scandal around a high-profile approval, and many months without permanent leadership at the FDA.
  
  Chris Morrison
  News Feature 15 Jan 2020

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Bioentrepreneur

Building a Business
- The biotech living and the walking dead
  
  A detailed look at the economic impact of university-licensed life science startups across the United States reveals vast differences in the effectiveness of different regions to create ventures and sustain them as viable entities.
  
  Paul C. Godfrey
  Gove N. Allen
  David Benson
  
  Collections:
  
  The Spinoff Prize 2020
  
  The Spinoff Prize 2021
  Building a Business 23 Jan 2020

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Correspondence

Genome editing in animals: why FDA regulation matters

Steven M. Solomon
Correspondence 07 Feb 2020
Assessing the impact of generative AI on medicinal chemistry

W. Patrick Walters
Mark Murcko
Correspondence 30 Jan 2020
Reply to ‘Assessing the impact of generative AI on medicinal chemistry’

Alex Zhavoronkov
Alán Aspuru-Guzik
Correspondence 30 Jan 2020
Droplet scRNA-seq is not zero-inflated

Valentine Svensson
Correspondence 14 Jan 2020

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Features

Patents
- Emerging patent landscape for non-viral vectors used for gene therapy
  
  An analysis of the emerging patent landscape of gene therapies under development, focusing on non-viral vectors.
  
  Virginia Picanço-Castro
  Cristiano Gonçalves Pereira
  Marxa Leão Figueiredo
  Patents 07 Feb 2020
- Lysosomes
  
  Recent patents related to lysosome-targeted therapeutics and methods of screening and visualization.
  
  Patents 07 Feb 2020

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News & Views

Reading amino acids in a nanopore

In a step toward nanopore sequencing of proteins, an aerolysin pore discriminates many of the proteinogenic amino acids.

Stefan Howorka
Zuzanna S. Siwy
News & Views 23 Jan 2020
Vertical farms bear fruit

Engineering perishable crops for use in indoor farms promises to expand the adoption of this high-yielding, efficient means of food production.

Cathryn A. O’Sullivan
C. Lynne McIntyre
Graham D. Bonnett
News & Views 14 Jan 2020

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Research

Matters Arising
- Template plasmid integration in germline genome-edited cattle
  
  Alexis L. Norris
  Stella S. Lee
  Heather A. Lombardi
  Matters Arising 07 Feb 2020
Brief Communications
- Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor
  
  Efficient diversification of DNA sequences is enabled by a T7 RNA polymerase fused to a cytidine deaminase.
  
  Haiqi Chen
  Sophia Liu
  Fei Chen
  Brief Communication 16 Dec 2019
Letters
- A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo
  
  In vivo control of expression levels of AAV-delivered genes is enabled by an engineered RNA switch.
  
  Guocai Zhong
  Haimin Wang
  Michael Farzan
  Letter 23 Dec 2019
- Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore
  
  Individual amino acids fused to a highly charged heptapeptide are discriminated in an aerolysin nanopore.
  
  Hadjer Ouldali
  Kumar Sarthak
  Abdelghani Oukhaled
  Letter 16 Dec 2019
- Rapid customization of Solanaceae fruit crops for urban agriculture
  
  Compact early fruiting tomato and groundcherry plants suitable for urban farming are produced using genome editing.
  
  Choon-Tak Kwon
  Jung Heo
  Zachary B. Lippman
  Letter 23 Dec 2019
Articles
- An integrated perfusion machine preserves injured human livers for 1 week
  
  Livers are stored long term in a sophisticated perfusion system.
  
  Dilmurodjon Eshmuminov
  Dustin Becker
  Pierre-Alain Clavien
  Article 13 Jan 2020
- A large peptidome dataset improves HLA class I epitope prediction across most of the human population
  
  Prediction of HLA class I epitopes is improved in accuracy and breath with peptidomes from 95 mono-allelic cell lines.
  
  Siranush Sarkizova
  Susan Klaeger
  Derin B. Keskin
  Article 16 Dec 2019
- The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO₂
  
  A yeast species used to produce proteins and chemicals is engineered to grow solely on the greenhouse gas CO₂.
  
  Thomas Gassler
  Michael Sauer
  Matthias G. Steiger
  Article 16 Dec 2019
- A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat
  
  Low levels of uric acid and tyrosine in sweat are detected in patients with gout and healthy individuals with an entirely laser-engraved wearable sensor.
  
  Yiran Yang
  Yu Song
  Wei Gao
  Article 25 Nov 2019
Analysis
- Genomic and phenotypic analyses of six offspring of a genome-edited hornless bull
  
  A genome-edited hornless compound heterozygous dairy bull transmitted this trait to his offspring.
  
  Amy E. Young
  Tamer A. Mansour
  Alison L. Van Eenennaam
  Analysis Open Access 07 Oct 2019
- The therapeutic landscape for cells engineered with chimeric antigen receptors
  
  A survey of the landscape of targets of chimeric antigen receptor cell therapies currently in clinical trials, with a browsable portal for patients and clinicians.
  
  Matthew MacKay
  Ebrahim Afshinnekoo
  Christopher E. Mason
  Analysis 06 Jan 2020

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Amendments & Corrections

Author Correction: Genomic and phenotypic analyses of six offspring of a genome-edited hornless bull

Amy E. Young
Tamer A. Mansour
Alison L. Van Eenennaam
Author Correction Open Access 28 Jan 2020
Publisher Correction: In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription

Amjad Askary
Luis Sanchez-Guardado
Michael B. Elowitz
Publisher Correction 27 Jan 2020

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Careers & Recruitment

Career Feature
- Fourth-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 07 Feb 2020
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 07 Feb 2020

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Volume 38 Issue 2, February 2020

Engineering plants for vertical farms

Editorial

News

First Rounders Podcast

Data Page

News Feature

Bioentrepreneur

Building a Business

Correspondence

Features

Patents

News & Views

Research

Matters Arising

Brief Communications

Letters

Articles

Analysis

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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