Volume 37 Issue 4, April 2019

Volume 37 Issue 4

Focus on wearable sensors

Wearable sensors are evolving to provide accurate, continuous and wireless monitoring of our health and disease states. Using designs and materials that interface seamlessly with skin, accessing a range of bodily fluids with minimally invasive systems, and measuring analytes that inform on human physiology, wearable devices are poised to provide data resources for research and clinical applications.

See In this issue

Image: J. Rogers, Northwestern University. Cover Design: Erin Dewalt.

In This Issue

Editorial

  • Editorial |

    The outgoing FDA commissioner’s comments on the slow integration of data from mobile platforms into clinical research highlight the challenges facing real-world applications of wearables.

News

Bioentrepreneur

    Building a Business

  • articles |

    A deep dive into the influence of research output, patenting, venture capital and human capital on startup financing activity in Europe reveals not all countries are equal.

    • Bonnie van Wilgenburg
    • , Kim van Wilgenburg
    • , Kathryn Paisner
    • , Sander van Deventer
    •  & Rogier W. Rooswinkel

Correspondence

Features

News & Views

  • News & Views |

    Human brain organoids are endowed with regional topography using engineered signaling centers.

    • Yuki Miura
    •  & Sergiu P. Pașca
  • News & Views |

    Large brain tissue sections are imaged with nanoscale resolution using expansion and lattice light sheet microscopy.

    • Weijian Yang
    •  & Rafael Yuste

Research

    Perspectives

  • Review Articles

  • Review Article |

    Assessing progress towards designing reliable wearable biosensors reveals the challenges remaining before the promise of clinical translation can be realized.

    • Jayoung Kim
    • , Alan S. Campbell
    • , Berta Esteban-Fernández de Ávila
    •  & Joseph Wang
  • Review Article |

    Heikenfeld et al. survey the range of biochemical analytes that can be sensed in dermal interstitial fluid, saliva and sweat, and outline criteria for tailoring sensor design to address the right analyte in the right body site for the right disease or wellness application.

    • Jason Heikenfeld
    • , Andrew Jajack
    • , Benjamin Feldman
    • , Steve W. Granger
    • , Supriya Gaitonde
    • , Gavi Begtrup
    •  & Benjamin A. Katchman
  • Brief Communications

  • Brief Communication |

    SignalP 5.0 improves proteome-wide detection of signal peptides across all organisms and can distinguish between different types of signal peptides in prokaryotes.

    • José Juan Almagro Armenteros
    • , Konstantinos D. Tsirigos
    • , Casper Kaae Sønderby
    • , Thomas Nordahl Petersen
    • , Ole Winther
    • , Søren Brunak
    • , Gunnar von Heijne
    •  & Henrik Nielsen
  • Letters

  • Letter |

    Supplying forebrain organoids with a developmental signaling gradient induces topographical patterning along dorso-ventral and antero-posterior axes.

    • Gustav Y. Cederquist
    • , James J. Asciolla
    • , Jason Tchieu
    • , Ryan M. Walsh
    • , Daniela Cornacchia
    • , Marilyn D. Resh
    •  & Lorenz Studer
  • Articles

  • Article |

    A new computational method allows key developmental checkpoints and important parameters of population dynamics to be inferred from single-cell RNA-sequencing time series data.

    • David S. Fischer
    • , Anna K. Fiedler
    • , Eric M. Kernfeld
    • , Ryan M. J. Genga
    • , Aimée Bastidas-Ponce
    • , Mostafa Bakhti
    • , Heiko Lickert
    • , Jan Hasenauer
    • , Rene Maehr
    •  & Fabian J. Theis

Amendments & Corrections

Careers & Recruitment

    Career Feature

  • Career Feature |

    A report by the Coalition of State Bioscience Institutes details the US life science industry’s workforce needs and what it must do to maintain its competitive advantage in the worldwide market.

    • Lori Lindburg
    • , Liisa Bozinovic
    •  & Ron Susek
  • People

  • People |

    A sample of goings-on in and around the biotech and pharmaceutical industry.