Volume 37 Issue 2, February 2019

Volume 37 Issue 2

Ultrafast searching for microbial sequences

A representation of bacteria and viruses (not to scale), along with a search bar and a DNA query. Bradley et al. report an approach for building a search index of the global archives of microbial DNA.

See Bradley et al.

Image credit: Spencer Phillips Cover design: Erin Dewalt

Editorial

  • Editorial |

    The acquisition of Celgene is bad news for young biotech companies with innovative products and platforms to sell.

News

Correspondence

Features

    Patents

  • Patents |

    Recent patents in siRNA, antisense oligonucleotides, and CRISPR.

News & Views

  • News & Views |

    Cassava engineered to retain more iron and zinc faces challenges before moving into fields and onto forks.

    • Marc Ghislain
    • , Tawanda Muzhingi
    •  & Jan W. Low

Research

    Letters

  • Letter |

    The treasure trove of disease resistance genes present in wild relatives of domesticated crops is rapidly discovered using association genetics and enrichment sequencing.

    • Sanu Arora
    • , Burkhard Steuernagel
    • , Kumar Gaurav
    • , Sutha Chandramohan
    • , Yunming Long
    • , Oadi Matny
    • , Ryan Johnson
    • , Jacob Enk
    • , Sambasivam Periyannan
    • , Narinder Singh
    • , M. Asyraf Md Hatta
    • , Naveenkumar Athiyannan
    • , Jitender Cheema
    • , Guotai Yu
    • , Ngonidzashe Kangara
    • , Sreya Ghosh
    • , Les J. Szabo
    • , Jesse Poland
    • , Harbans Bariana
    • , Jonathan D. G. Jones
    • , Alison R. Bentley
    • , Mick Ayliffe
    • , Eric Olson
    • , Steven S. Xu
    • , Brian J. Steffenson
    • , Evans Lagudah
    •  & Brande B. H. Wulff

    • Articles

  • Article |

    A sensitive method to analyze metagenomes, CATCH, enables detection and characterization of diverse viral sequences, including the 356 viruses known to infect humans.

    • Hayden C. Metsky
    • , Katherine J. Siddle
    • , Adrianne Gladden-Young
    • , James Qu
    • , David K. Yang
    • , Patrick Brehio
    • , Andrew Goldfarb
    • , Anne Piantadosi
    • , Shirlee Wohl
    • , Amber Carter
    • , Aaron E. Lin
    • , Kayla G. Barnes
    • , Damien C. Tully
    • , Bjӧrn Corleis
    • , Scott Hennigan
    • , Giselle Barbosa-Lima
    • , Yasmine R. Vieira
    • , Lauren M. Paul
    • , Amanda L. Tan
    • , Kimberly F. Garcia
    • , Leda A. Parham
    • , Ikponmwosa Odia
    • , Philomena Eromon
    • , Onikepe A. Folarin
    • , Augustine Goba
    • , Etienne Simon-Lorière
    • , Lisa Hensley
    • , Angel Balmaseda
    • , Eva Harris
    • , Douglas S. Kwon
    • , Todd M. Allen
    • , Jonathan A. Runstadler
    • , Sandra Smole
    • , Fernando A. Bozza
    • , Thiago M. L. Souza
    • , Sharon Isern
    • , Scott F. Michael
    • , Ivette Lorenzana
    • , Lee Gehrke
    • , Irene Bosch
    • , Gregory Ebel
    • , Donald S. Grant
    • , Christian T. Happi
    • , Daniel J. Park
    • , Andreas Gnirke
    • , Pardis C. Sabeti
    •  & Christian B. Matranga

  • Article |

    RNA-binding proteins can be identified and quantified in any organism using a simple method that combines UV cross-linking and phase separation.

    • Rayner M. L. Queiroz
    • , Tom Smith
    • , Eneko Villanueva
    • , Maria Marti-Solano
    • , Mie Monti
    • , Mariavittoria Pizzinga
    • , Dan-Mircea Mirea
    • , Manasa Ramakrishna
    • , Robert F. Harvey
    • , Veronica Dezi
    • , Gavin H. Thomas
    • , Anne E. Willis
    •  & Kathryn S. Lilley

    • Resources

  • Resource | | open

    A resource of >1,500 bacterial reference genomes sheds light on the human gut microbiome.

    • Yuanqiang Zou
    • , Wenbin Xue
    • , Guangwen Luo
    • , Ziqing Deng
    • , Panpan Qin
    • , Ruijin Guo
    • , Haipeng Sun
    • , Yan Xia
    • , Suisha Liang
    • , Ying Dai
    • , Daiwei Wan
    • , Rongrong Jiang
    • , Lili Su
    • , Qiang Feng
    • , Zhuye Jie
    • , Tongkun Guo
    • , Zhongkui Xia
    • , Chuan Liu
    • , Jinghong Yu
    • , Yuxiang Lin
    • , Shanmei Tang
    • , Guicheng Huo
    • , Xun Xu
    • , Yong Hou
    • , Xin Liu
    • , Jian Wang
    • , Huanming Yang
    • , Karsten Kristiansen
    • , Junhua Li
    • , Huijue Jia
    •  & Liang Xiao

  • Resource | | open

    A large bacterial strain collection and genome sequences will boost gut microbiome research.

    • Samuel C. Forster
    • , Nitin Kumar
    • , Blessing O. Anonye
    • , Alexandre Almeida
    • , Elisa Viciani
    • , Mark D. Stares
    • , Matthew Dunn
    • , Tapoka T. Mkandawire
    • , Ana Zhu
    • , Yan Shao
    • , Lindsay J. Pike
    • , Thomas Louie
    • , Hilary P. Browne
    • , Alex L. Mitchell
    • , B. Anne Neville
    • , Robert D. Finn
    •  & Trevor D. Lawley

Amendments & Corrections

Careers & Recruitment

    Career Feature

  • Career Feature |

    A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.

    • Michael Francisco

    • People

  • People |

    A sample of goings on in and around the biotech and pharmaceutical industry.