Volume 37 Issue 11, November 2019

RNA dynamics live

A series of bright fluorescent RNAs enable imaging of RNA in live cells. This original image shows heterogeneity of protein translation in a cancer cell line, where mCherry protein (red) and its corresponding mRNA (green, labeled with Pepper530) are seen. Blue indicates Hoechst DNA staining.

See Chen et al.

Image: Ni Su. Cover Design: Erin Dewalt

Editorial

The next biotech superpower

China is set to challenge the pre-eminence of the US drug market. If it can address gaps in its R&D ecosystem and clinical infrastructure, it may even become a home for biotech innovators.

Editorial 05 Nov 2019

Advertisement

Top of page ⤴

News

Monster investment puts Baltimore on biotech startup map

With neuroinflammation, fibrosis, genomics and apoptosis research to the fore, Johns Hopkins is ramping up its output of startups with a little help from Korea.

Cormac Sheridan
News 04 Oct 2019
FDA snubs Sarepta’s exon 53-targeting dystrophy drug

FDA’s rebuff of Sarepta’s new antisense drug leaves the Duchenne community perplexed.

Mark Zipkin
News 25 Sept 2019
Race for undruggable KRAS speeds up

News in Brief 05 Nov 2019
Moderna jockeys into Harvard

News in Brief 05 Nov 2019
Deerfield builds NYC campus to support life sciences startups

The move is the latest in the investor’s shift toward supporting early-stage companies.

Melanie Senior
News 08 Oct 2019
Meat-free outsells beef

News in Brief 05 Nov 2019
With CRISPR and machine learning, startups fast-track crops to consume less, produce more

Small players take on big seed conglomerates with next-generation non-GMO crops.

Emily Waltz
News 24 Sept 2019
Around the world in a month

News in Brief 05 Nov 2019
First Rounders Podcast
- First Rounders: Samantha Du
  
  First Rounders Podcast 29 Oct 2019
Data Page
- 3Q19—Biotech funding stagnates
  
  Laura DeFrancesco
  Data Page 05 Nov 2019
News Feature
- Their lives in their hands
  
  The devastating diagnosis of a rare disease is prompting an increasing number of people to go to the bench and take research into their own hands
  
  Malorye Allison Branca
  News Feature 01 Nov 2019

Top of page ⤴

Correspondence

Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence 03 Oct 2019

Top of page ⤴

Features

‘Innovation’ nation

China is finally embracing biopharmaceutical innovation, but it is innovation that looks different from that in the West.

Brady Huggett
Feature 29 Oct 2019
Patents
- Microbiomes
  
  Recent patents related to methods of assessing microbiome health and treatments of microbiome-related conditions.
  
  Patents 05 Nov 2019

Top of page ⤴

News & Views

Culturing the uncultured

Bacterial species that have eluded cultivation are selectively brought into culture.

William H. Lewis
Thijs J. G. Ettema
News & Views 09 Oct 2019
A SWEET solution to rice blight

Two studies offer a powerful strategy for combating bacterial blight in rice.

Rajeev K. Varshney
Ian D. Godwin
Susan R. McCouch
News & Views 28 Oct 2019

Top of page ⤴

Research

Brief Communications
- Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
  
  HLA class II epitopes are accurately predicted by analysis of a large peptide dataset.
  
  Julien Racle
  Justine Michaux
  David Gfeller
  Brief Communication 14 Oct 2019
Letters
- Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs
  
  A series of bright fluorescent RNAs with a broad emission spectra enable live cell imaging of RNA dynamics.
  
  Xianjun Chen
  Dasheng Zhang
  Yi Yang
  Letter 23 Sept 2019
- Simultaneous repression of multiple bacterial genes using nonrepetitive extra-long sgRNA arrays
  
  Stable multi-gene CRISPR interference using nonrepetitive genetic parts and system design.
  
  Alexander C. Reis
  Sean M. Halper
  Howard M. Salis
  Letter 07 Oct 2019
Articles
- In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma
  
  A hybrid AAV–transposon CRISPR approach enables large-scale in vivo screens in T cells and identifies potential targets for immunotherapy.
  
  Lupeng Ye
  Jonathan J. Park
  Sidi Chen
  Article 23 Sept 2019
- Targeted isolation and cultivation of uncultivated bacteria by reverse genomics
  
  Microbial ‘dark matter’ is brought into culture using reverse genomics.
  
  Karissa L. Cross
  James H. Campbell
  Mircea Podar
  Article 30 Sept 2019
- In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles
  
  Biocompatible rare-earth nanoparticles with an emission maximum at 1,600 nm enable sensitive in vivo imaging.
  
  Yeteng Zhong
  Zhuoran Ma
  Hongjie Dai
  Article 30 Sept 2019
- Predicting HLA class II antigen presentation through integrated deep learning
  
  A neural network trained on diverse datasets improves prediction of HLA class II epitope presentation.
  
  Binbin Chen
  Michael S. Khodadoust
  Ash A. Alizadeh
  Article 14 Oct 2019
- Broad-spectrum resistance to bacterial blight in rice using genome editing
  
  Genome editing of three SWEET gene promoters endows rice with resistance to all Xanthomonas bacterial blight strains tested.
  
  Ricardo Oliva
  Chonghui Ji
  Bing Yang
  Article Open Access 28 Oct 2019
Analysis
- Integrated genomic profiling expands clinical options for patients with cancer
  
  Genomic profiling of cancer samples yields more therapeutic options by including germline, RNA-seq and immunotherapy biomarkers.
  
  Nike Beaubier
  Martin Bontrager
  Kevin P. White
  Analysis 30 Sept 2019
Resources
- Co-regulation map of the human proteome enables identification of protein functions
  
  Human protein co-regulation map is derived from a large set of quantitative proteomics experiments.
  
  Georg Kustatscher
  Piotr Grabowski
  Juri Rappsilber
  Resource 04 Nov 2019
- Diagnostic kit for rice blight resistance
  
  Strategic deployment of blight-resistant rice lines is enabled by a molecular diagnostic kit.
  
  Joon-Seob Eom
  Dangping Luo
  Wolf B. Frommer
  Resource Open Access 28 Oct 2019

Top of page ⤴

Amendments & Corrections

Author Correction: Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs

Liang Qu
Zongyi Yi
Wensheng Wei
Author Correction 25 Sept 2019
Author Correction: Data privacy in the age of personal genomics

Dennis Grishin
Kamal Obbad
George M. Church
Author Correction 07 Oct 2019
Author Correction: Precision electronic medicine in the brain

Shaun R. Patel
Charles M. Lieber
Author Correction 24 Oct 2019

Top of page ⤴

Careers & Recruitment

Career Feature
- Third-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 05 Nov 2019
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 05 Nov 2019

Top of page ⤴

Volume 37 Issue 11, November 2019

RNA dynamics live

Editorial

News

First Rounders Podcast

Data Page

News Feature

Correspondence

Features

Patents

News & Views

Research

Brief Communications

Letters

Articles

Analysis

Resources

Amendments & Corrections

Careers & Recruitment

Career Feature

People

Search

Quick links