Volume 36 Issue 9, September 2018

Volume 36 Issue 9

Image from the video game EVE Online with a background of fluorescently labeled cells. Sullivan et al. report how the analysis of large-scale imaging experiments was facilitated by incorporating an image classification task as a minigame in this mainstream massively multiplayer online game and by intergrating the player annotations with deep learning approaches (p 820). Image credit: Sölvi Hrafn Ingimundarson (CCP games) and the Human Protein Atlas

Editorials

  • Editorial |

    The US approval of Onpattro—the first of a new class of small-interfering RNA (siRNA) drug—is a triumph for Alnylam and vindication for its leadership.

  • Editorial |

    By lumping gene-edited plants together with other genetically modified organisms (GMOs), Europe's highest court has consigned this plant-breeding approach to a regulatory black hole.

News

News Feature

  • News Feature |

    A cadre of new biotechs have set their sights on targeting RNA with small-molecule drugs. Justin Petrone and Laura DeFrancesco report.

    • Justin Petrone
    •  & Laura DeFrancesco

  • Bioentrepreneur |

    South Korea's 8-year effort to create an integrated platform for novel target and lead development provides an academic drug discovery model for other emerging economies.

    • Thomas X Neenan
    • , Robert E Burrier
    •  & Sunghoon Kim
  • Data Page

Correspondence

Commentary

  • Commentary |

    Greater safeguards are needed to address the personal safety, security and privacy risks arising from increasing adoption of neurotechnology in the consumer realm.

    • Marcello Ienca
    • , Pim Haselager
    •  & Ezekiel J Emanuel

Feature

News and Views

  • News & Views |

    A new model for representing genomes aims to capture the breadth of genetic diversity in populations.

    • Deanna M Church

Research Highlights

News and Views

Research

    Perspective

  • Perspective |

    Brendan Frey and colleagues provide a personal overview of the machine learning field and in particular deep learning. They outline the technical challenges in applying machine learning to different types of biological and biomedical data and go on to discuss the challenges in implementing these approaches in the clinical realm, in drug discovery programs and within regulatory agencies.

    • Michael Wainberg
    • , Daniele Merico
    • , Andrew Delong
    •  & Brendan J Frey
  • Analysis

  • Analysis |

    Pattern recognition in imaging data by >300,000 players of a global, online, commercial computer game is combined with deep learning to improve the accuracy of annotation of subcellular protein localization.

    • Devin P Sullivan
    • , Casper F Winsnes
    • , Lovisa Åkesson
    • , Martin Hjelmare
    • , Mikaela Wiking
    • , Rutger Schutten
    • , Linzi Campbell
    • , Hjalti Leifsson
    • , Scott Rhodes
    • , Andie Nordgren
    • , Kevin Smith
    • , Bernard Revaz
    • , Bergur Finnbogason
    • , Attila Szantner
    •  & Emma Lundberg
  • Brief Communications

  • Brief Communication |

    Diseases caused by different mutations in the two alleles of a gene are treated in mice by Cas-9-induced allelic exchange.

    • Dan Wang
    • , Jia Li
    • , Chun-Qing Song
    • , Karen Tran
    • , Haiwei Mou
    • , Pei-Hsuan Wu
    • , Phillip W L Tai
    • , Craig A Mendonca
    • , Lingzhi Ren
    • , Blake Y Wang
    • , Qin Su
    • , Dominic J Gessler
    • , Phillip D Zamore
    • , Wen Xue
    •  & Guangping Gao
  • Articles

  • Article |

    Anti-PD-1 secreted by CAR-T cells remains localized to the tumor and improves therapeutic outcome in mice.

    • Sarwish Rafiq
    • , Oladapo O Yeku
    • , Hollie J Jackson
    • , Terence J Purdon
    • , Dayenne G van Leeuwen
    • , Dylan J Drakes
    • , Mei Song
    • , Matthew M Miele
    • , Zhuoning Li
    • , Pei Wang
    • , Su Yan
    • , Jingyi Xiang
    • , Xiaojing Ma
    • , Venkatraman E Seshan
    • , Ronald C Hendrickson
    • , Cheng Liu
    •  & Renier J Brentjens
  • Article |

    Synthetic probiotic for a human metabolic disease is taken through a drug development pathway to enable translation into clinic trials.

    • Vincent M Isabella
    • , Binh N Ha
    • , Mary Joan Castillo
    • , David J Lubkowicz
    • , Sarah E Rowe
    • , Yves A Millet
    • , Cami L Anderson
    • , Ning Li
    • , Adam B Fisher
    • , Kip A West
    • , Philippa J Reeder
    • , Munira M Momin
    • , Christopher G Bergeron
    • , Sarah E Guilmain
    • , Paul F Miller
    • , Caroline B Kurtz
    •  & Dean Falb
  • Article |

    Three linked microfluidic chips model transport across the blood–brain barrier.

    • Ben M Maoz
    • , Anna Herland
    • , Edward A FitzGerald
    • , Thomas Grevesse
    • , Charles Vidoudez
    • , Alan R Pacheco
    • , Sean P Sheehy
    • , Tae-Eun Park
    • , Stephanie Dauth
    • , Robert Mannix
    • , Nikita Budnik
    • , Kevin Shores
    • , Alexander Cho
    • , Janna C Nawroth
    • , Daniel Segrè
    • , Bogdan Budnik
    • , Donald E Ingber
    •  & Kevin Kit Parker
  • Letters

  • Letter |

    The efficiency of base editing is substantially increased by optimizing expression and nuclear localization of the editing enzymes.

    • Maria Paz Zafra
    • , Emma M Schatoff
    • , Alyna Katti
    • , Miguel Foronda
    • , Marco Breinig
    • , Anabel Y Schweitzer
    • , Amber Simon
    • , Teng Han
    • , Sukanya Goswami
    • , Emma Montgomery
    • , Jordana Thibado
    • , Edward R Kastenhuber
    • , Francisco J Sánchez-Rivera
    • , Junwei Shi
    • , Christopher R Vakoc
    • , Scott W Lowe
    • , Darjus F Tschaharganeh
    •  & Lukas E Dow

    Collection:

Careers and Recruitment

  • Careers and Recruitment |

    Adapting the clinical residency training model can help postdoctoral research fellows navigate and personalize their training experience for their unique career goals.

    • Mindy Kim Graham
    • , Ben Ho Park
    •  & Nicolas Wyhs
  • People

  • Careers and Recruitment |

Errata