Despite spooking investors, new insights into DNA repair and the CRISPR gene-editing system are part and parcel of its progress from research tool to human therapy.
Volume 36 Issue 8, September 2018
Life sciences company decision-makers can effectively manage disputes using appropriate dispute resolution techniques without resorting to expensive, complex, and uncertain litigation.
News & Views
Multiplexed identification, quantification and genotyping of infectious agents using a semiconductor biochip
Rapid, multiplex identification of pathogens and disease-associated mutations is possible with a new semiconductor biochip.
Systematic evaluation of library preparation methods for small RNA-seq identifies reproducible and accurate methods.
Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme
Therapeutic inhibition of the immunosuppressive IDO1–TDO pathway in tumors is achieved in vivo with an enzyme.
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
Cas9-induced double stranded breaks can cause large deletions near the target site and more complex genomic rearrangements in mouse and human stem cells.