Volume 36 Issue 5, May 2018

Artist's impression of how deep learning accelerates super resolution microscopy. Ouyang et al. present a computational approach that uses artificial neural networks to reconstruct super-resolution images from noisy images recorded at high speed with single-molecule localization microscopy (p. 460). Image credit: Wei Ouyang and Xiangping Li

Editorial

Unleashing biotech's crouching tiger

With a massive expansion in healthcare coverage, biotech's next big boom could occur in India. But this revolution will not be globalized—it will be about serving national needs.

Editorial 09 May 2018

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News

Allogene and Celularity move CAR-T therapy off the shelf

Cormac Sheridan
News 09 May 2018
Cytokine resurrection: engineered IL-2 ramps up immuno-oncology responses

Ken Garber
News 09 May 2018
2020 African American genomes

News 09 May 2018
Indian biotech sector readies for liftoff

Killugudi Jayaraman
News 09 May 2018
Patent challenges to antibody and gene-therapy firms on the rise

Charlotte Harrison
News 09 May 2018
Trump threatens then signs, a win for FDA, NIH

News 09 May 2018
To keep biotechs trading at home, China pilots new stock market rules

Shannon Ellis
News 09 May 2018
Around the world in a month

News 09 May 2018

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Data Page

Drug pipeline: 1Q18

Laura DeFrancesco
Data Page 09 May 2018

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Bioentrepreneur

A rich resource

Employing graduate students and post-doctoral fellows in technology transfer groups

Ahmet-Hamdi Cavusoglu
Elizabeth Beerman
Orin Herskowitz
Bioentrepreneur 09 May 2018

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Correspondence

Alternative models for sharing confidential biomedical data

Justin Guinney
Julio Saez-Rodriguez
Correspondence 09 May 2018

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Feature

Bringing up baby

More investors are building companies from scratch, with more money than any time in biotech's history.

Brady Huggett
Feature 09 May 2018
First rounders: John Maraganore

John Maraganore
Feature 09 May 2018

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Patents

Patentability of antibodies for therapeutic use in Europe

General guidelines are presented on the types of patent protection available for inventions arising from research in the field of monoclonal antibodies, using concepts drawn from European case law and expert practice.

Claudio Germinario
Sara Bertoli
Maurizio Cini
Patents 09 May 2018
Recent patents in biomedical imaging

Patents 09 May 2018

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News & Views

Brain organoids get vascularized

Transplantation of cerebral organoids into the mouse brain overcomes some limitations of in vitro systems.

Madeline A Lancaster

Collection:

Organoid research
News & Views 09 May 2018
Boosting the power of single-cell analysis

Data sets from different single-cell RNA-seq experiments are combined with reduced technical error.

Lu Wen
Fuchou Tang
News & Views 09 May 2018
All the skin that's fit to print

Irene Jarchum
News & Views 09 May 2018
Research Highlights

News & Views 09 May 2018

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Analysis

Integrating single-cell transcriptomic data across different conditions, technologies, and species

A new computational approach enables integrative analysis of disparate single-cell RNA–sequencing data sets by identifying shared patterns of variation between cell subpopulations.

Andrew Butler
Paul Hoffman
Rahul Satija

Milestone:

Genomic Sequencing
Analysis 02 Apr 2018
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

Differences in gene expression between individual cells of the same type are measured across batches and used to correct technical artifacts in single-cell RNA-sequencing data.

Laleh Haghverdi
Aaron T L Lun
John C Marioni
Analysis 02 Apr 2018

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Brief Communication

Highly scalable generation of DNA methylation profiles in single cells

Methylation profiling of single cells in high throughput achieves read-alignment rates approaching bulk cell population studies.

Ryan M Mulqueen
Dmitry Pokholok
Andrew C Adey
Brief Communication 09 Apr 2018

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Article

An in vivo model of functional and vascularized human brain organoids

Human cerebral organoids undergo vascularization and maturation in the mouse brain.

Abed AlFatah Mansour
J Tiago Gonçalves
Fred H Gage

Collections:

Stem cells from development to the clinic

Stem cells from development to the clinic

25th Anniversary Collection

Organoid research
Article 16 Apr 2018
Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain

scGESTALT enables large-scale characterization of cell types and lineage relationships during vertebrate brain development.

Bushra Raj
Daniel E Wagner
Alexander F Schier
Article 28 Mar 2018
Fast, long-term, super-resolution imaging with Hessian structured illumination microscopy

An improved image reconstruction algorithm increases time resolution and maximal imaging time for super-resolution microscopy.

Xiaoshuai Huang
Junchao Fan
Liangyi Chen
Article 11 Apr 2018
Deep learning massively accelerates super-resolution localization microscopy

Accelerating PALM/STORM microscopy with deep learning allows super-resolution imaging of >1,000 cells in a few hours.

Wei Ouyang
Andrey Aristov
Christophe Zimmer

Collections:

Deep learning in microscopy

The multidisciplinary nature of machine intelligence
Article 16 Apr 2018

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Letter

Simultaneous lineage tracing and cell-type identification using CRISPR–Cas9-induced genetic scars

LINNAEUS reconstructs developmental lineages using RNA sequencing data and lineage markers from the same single cells.

Bastiaan Spanjaard
Bo Hu
Jan Philipp Junker
Letter 09 Apr 2018

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Careers and Recruitment

First-quarter biotech job picture

Michael Francisco
Careers and Recruitment 09 May 2018
People

Careers and Recruitment 09 May 2018

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Volume 36 Issue 5, May 2018

Editorial

News

Data Page

Bioentrepreneur

Correspondence

Feature

Patents

News & Views

Analysis

Brief Communication

Article

Letter

Careers and Recruitment

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