Volume 36 Issue 4, April 2018

Editorial

The long view on sequencing

Ultra-long read, single-molecule nanopore sequencers are beginning to find an expanding set of research applications in both human genomics and pathogenomics.

Editorial 05 Apr 2018

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News

Roche pays $1.9 billion for Flatiron's army of electronic health record curators

Justin Petrone
News 05 Apr 2018
FDA approves stroke-detecting AI software

News 05 Apr 2018
New drug for multidrug-resistant HIV

News 05 Apr 2018
Rollout of high-priced cell and gene therapies forces payer rethink

Melanie Senior
News 05 Apr 2018
Low-molecular-weight albumin drug touted for severe osteoarthritis

Cormac Sheridan
News 05 Apr 2018
Critics say 'right to try' wrong for patients

Christopher Morrison
News 05 Apr 2018
Around the world in a month

News 05 Apr 2018

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Feature

Nature Biotechnology's academic spinouts of 2017

Our annual survey highlights how immune-oncology and screens based on the application of cutting-edge omics technologies are providing a launchpad for a succession of startups interrogating biology across biomedicine.

Malorye Allison Branca
Ken Garber
Laura DeFrancesco
Feature 05 Apr 2018

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Patents

Gender differences in obtaining and maintaining patent rights

An examination of the prosecution and maintenance histories of approximately 2.7 million US patent applications indicates that women have less favorable outcomes than men.

Kyle Jensen
Balázs Kovács
Olav Sorenson
Patents 05 Apr 2018
Recent patents in tumor detection and treatment

Patents 05 Apr 2018

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News & Views

Patching the retina with stem cells

An engineered patch of retinal pigment epithelium shows promise in two macular degeneration patients.

Kapil Bharti
News & Views 05 Apr 2018
Portable gene expression guaranteed

Synthetic biology is made more reliable by borrowing ideas from systems and control theory.

Marios Tomazou
Guy-Bart Stan
News & Views 05 Apr 2018
Research Highlights

News & Views 05 Apr 2018
Epigenome editing to the rescue

Markus Elsner
News & Views 05 Apr 2018

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Perspective

Metabolomics activity screening for identifying metabolites that modulate phenotype

Metabolomics activity screening can identify small-molecule metabolites that are readily available and can be used to alter phenotypes, including stem cell differentiation, T-cell survival, oligodendrocyte maturation, and insulin signaling.

Carlos Guijas
J Rafael Montenegro-Burke
Gary Siuzdak
Perspective 05 Apr 2018

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Brief Communication

Linear assembly of a human centromere on the Y chromosome

Repeat regions in the human Y chromosome centromere are assembled using long-read nanopore sequencing.

Miten Jain
Hugh E Olsen
Karen H Miga
Brief Communication Open Access 19 Mar 2018
Base editing with a Cpf1–cytidine deaminase fusion

A new fusion protein enables precise editing of single bases in A/T-rich regions of the human genome.

Xiaosa Li
Ying Wang
Jia Chen
Brief Communication 19 Mar 2018

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Article

Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

An engineered patch of retinal pigment epithelium generated from human embryonic stem cells is transplanted into the eyes of two patients.

Lyndon da Cruz
Kate Fynes
Peter J Coffey

Collection:

Stem cells from development to the clinic
Article 19 Mar 2018
Nanopore sequencing and assembly of a human genome with ultra-long reads

A human genome is sequenced and assembled de novo using a pocket-sized nanopore device.

Miten Jain
Sergey Koren
Matthew Loose
Article Open Access 29 Jan 2018

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Letter

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

Chimeric antigen receptor (CAR)-T cells expressing the cytokines IL-7 and CCL19 show improved clearance of established solid tumors in mice.

Keishi Adachi
Yosuke Kano
Koji Tamada
Letter 05 Mar 2018
Engineered promoters enable constant gene expression at any copy number in bacteria

A series of feedforward-stabilized bacterial gene promoters produce near-identical expression levels regardless of copy number changes due to altered genetic context, strain or growth conditions.

Thomas H Segall-Shapiro
Eduardo D Sontag
Christopher A Voigt
Letter 19 Mar 2018

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Resource

Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Rumen microbiome biology gets a boost with the release of 410 high-quality reference genomes from the Hungate1000 project.

Rekha Seshadri
Sinead C Leahy
William J Kelly
Resource Open Access 19 Mar 2018

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Erratum

Erratum: Open-source, community-driven microfluidics with Metafluidics

David S Kong
Todd A Thorsen
Peter A Carr
Erratum 05 Apr 2018
Erratum: The illusion of control in germline engineering policy

Harald König
Erratum 05 Apr 2018
Erratum: 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

Supratim Mukherjee
Rekha Seshadri
Nikos C Kyrpides
Erratum 05 Apr 2018
Erratum: Pearl millet genome sequence provides a resource to improve agronomic traits in arid environments

Rajeev K Varshney
Chengcheng Shi
Xun Xu
Erratum 05 Apr 2018
Erratum: Visualizing detailed postdoctoral employment trends using a new career outcome taxonomy

Hong Xu
Richard S T Gilliam
Tammy R L Collins
Erratum 05 Apr 2018

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Careers and Recruitment

Involving undergraduates in genomics research to narrow the education–research gap

Engaging undergraduates in computational tasks can improve genomic research laboratory productivity, benefiting both students and senior laboratory members.

Serghei Mangul
Lana S Martin
Eleazar Eskin

Nature Outlook:

Science and technology education
Careers and Recruitment 05 Apr 2018
People

Careers and Recruitment 05 Apr 2018

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Volume 36 Issue 4, April 2018

Editorial

News

Feature

Patents

News & Views

Perspective

Brief Communication

Article

Letter

Resource

Erratum

Careers and Recruitment

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