Volume 36 Issue 11, November 2018

Image depicts bacterial fragments being pieced together to form whole genomes. Bishara et al. report an approach that assembles short barcoded reads and generates high-quality draft microbial genomes (p 1067). Image credit: Ryan Charles Leung Brewster and Eli L. Moss. Credit corrected online 15 November 2018.

Editorial

Nobel work that galvanized an industry

The work of the 2018 Nobel Prize Chemistry awardees is remarkable not only for its influence on modern biotech, but also for the rapidity with which it translated to commercial products.

Editorial 09 Nov 2018

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News

No added sugar: antibody makers find an upside to 'no fucose'

Ken Garber
News 09 Nov 2018
Another CRISPR win for Zhang and Broad

Michael Francisco
News 09 Nov 2018
First preventive mAb for hereditary angioedema

Joana Osorio
News 09 Nov 2018
Wnt is back in drugmakers' sights, but is it druggable?

Cormac Sheridan
News 09 Nov 2018
Gilead injects own generics into shrinking HCV drug market

Christopher Morrison
News 09 Nov 2018

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Podcast

PODCAST: First rounders: Christoph Lengauer

Podcast 09 Nov 2018

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News

FDA calls for subscription model to pay for anti-infectives

Melanie Senior
News 09 Nov 2018
Bandit tusks

News 09 Nov 2018
Around the world in a month

News 09 Nov 2018

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Data Page

Q3 2018—The beat goes on

Laura DeFrancesco
Data Page 09 Nov 2018

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Correspondence

Evaluation of immune repertoire inference methods from RNA-seq data

Xihao Hu
Jian Zhang
Xiaole Shirley Liu
Correspondence 09 Nov 2018
Reply to "Evaluation of immune repertoire inference methods from RNA-seq data"

Dmitriy A Bolotin
Stanislav Poslavsky
Dmitriy M Chudakov
Correspondence 09 Nov 2018

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Feature

Translating microbiome futures

A group of microbiome researchers discuss some of the challenges in developing a new generation of microbiome therapies.

Gaspar Taroncher-Oldenburg
Susan Jones
Jun Wang
Feature 09 Nov 2018

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Patents

The Reporting Items for Patent Landscapes statement

James A Smith
Zeeshaan Arshad
Andrew J Carr
Patents 09 Nov 2018
Recent patents in endonucleases and genome editing

Patents 09 Nov 2018

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News & Views

Metagenomics meets read clouds

The assembly of individual genomes from complex microbial communities is improved by sequencing of barcoded fragments.

Jacqueline Goordial
Jennifer Ronholm
News & Views 09 Nov 2018
Proteomics goes parallel

Massively parallel sequencing of peptides could signal a new era of high-throughput proteomics.

Ben C Collins
Ruedi Aebersold
News & Views 09 Nov 2018
An avatar for precision cancer therapy

Screening patient-derived tumor cell cultures against a drug library is a promising adjunct to clinical decision-making.

Shumei Kato
Razelle Kurzrock
News & Views 09 Nov 2018
Research Highlights

News & Views 09 Nov 2018

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Brief Communication

Intron retention is a source of neoepitopes in cancer

Neoepitopes derived from intron retention events are processed and presented on MHC I in cancer cell lines.

Alicia C Smart
Claire A Margolis
Eliezer M Van Allen
Brief Communication 16 Aug 2018
Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine

Peptide identification in proteomics data is improved using an efficient open search engine.

Hao Chi
Chao Liu
Si-Min He
Brief Communication 08 Oct 2018

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Article

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

Complete population collapse of malaria vector Anopheles gambiae in cages is achieved using a gene drive that targets doublesex.

Kyros Kyrou
Andrew M Hammond
Andrea Crisanti
Article Open Access 24 Sept 2018
High-quality genome sequences of uncultured microbes by assembly of read clouds

Individual microbes in metagenomic samples are sequenced by assembly of barcoded short reads

Alex Bishara
Eli L Moss
Ami S Bhatt
Article 15 Oct 2018
Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures

Single-protein molecules are identified in parallel through fluorescence monitoring of Edman degradation.

Jagannath Swaminathan
Alexander A Boulgakov
Edward M Marcotte
Article 22 Oct 2018
Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase

A bisulfite-free sequencing method yields high-confidence 5hmC profiles in low-input samples.

Emily K Schutsky
Jamie E DeNizio
Rahul M Kohli
Article 08 Oct 2018
An integrative tissue-network approach to identify and test human disease genes

An integrative computational approach leverages data from model systems and human genome-wide studies to predict genes that have a functional role in disease.

Victoria Yao
Rachel Kaletsky
Olga G Troyanskaya
Article 22 Oct 2018
Rhizosphere microbiome structure alters to enable wilt resistance in tomato

Tomato rhizosphere microbiome alterations that contribute to bacterial wilt resistance are detected using metagenomics.

Min-Jung Kwak
Hyun Gi Kong
Jihyun F Kim

Collection:

The plant microbiome
Article 08 Oct 2018

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Letter

Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides

Cleavage products of the proteasome are profiled by mass spectrometry.

Hila Wolf-Levy
Aaron Javitt
Yifat Merbl
Letter 22 Oct 2018

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Author Correction

Correction: Author Correction: Rhizosphere microbiome structure alters to enable wilt resistance in tomato

Min-Jung Kwak
Hyun Gi Kong
Jihyun F Kim
Author Correction 09 Nov 2018

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Careers and Recruitment

Third-quarter biotech job picture

Michael Francisco
Careers and Recruitment 09 Nov 2018
People

Careers and Recruitment 09 Nov 2018

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Volume 36 Issue 11, November 2018

Editorial

News

Podcast

News

Data Page

Correspondence

Feature

Patents

News & Views

Brief Communication

Article

Letter

Author Correction

Careers and Recruitment

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