Volume 36 Issue 1, January 2018

A pseudocolored scanning electron microscopy image of nanobeads carrying VSVG-pseudotyped lenti viruses. Schubert et al. report a method to target single cells in live animals for viral transduction by guiding the magnetic beads to a cell in the mouse brain using an electromagnetic field (p 81). Image credit: G. Morison and R. Schubert, ETH Zürich, for SEM imaging and M. Oeggeli, Micronaut, for coloring.

Editorial

Aligning stars of all colors

The biotech industry needs to do more to recruit people from diverse groups.

Collection:

Achieving diversity in Research
Editorial 18 Dec 2017
Advertisement

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News

Drugmakers cling to dual IL-13/IL-4 blockbuster hopes

Cormac Sheridan
News 10 Jan 2018
AI for your heart, on your wrist

News 10 Jan 2018
First in vivo human genome editing trial

News 10 Jan 2018
FDA approves hereditary blindness gene therapy

News 10 Jan 2018
With a free pass, CRISPR-edited plants reach market in record time

Emily Waltz
News 10 Jan 2018
China's fledgling biotech sector fizzes into life

Shannon Ellis
News 10 Jan 2018
FDA to relax grip on at-home genetic tests, but concerns linger

Mark Ratner
News 10 Jan 2018
PODCAST: First rounders: Susan Windham-Bannister

News 10 Jan 2018
Bluebird's BCMA CAR-T impresses at ASH

News 10 Jan 2018
Texas displays 'Silicon Valley' credentials to lure Brazilian biotechs

Melanie Senior
News 10 Jan 2018
Around the world in a month

News 10 Jan 2018

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News Feature

DNA makes an appearance

How much can genome variation reveal about the appearance of an individual? Laura DeFrancesco investigates the field of molecular photofitting.

Laura DeFrancesco
News Feature 10 Jan 2018

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Correspondence

Why the European Union needs a national GMO opt-in mechanism

Dennis Eriksson
Eugénia de Andrade
Tomáš Vaněk
Correspondence 10 Jan 2018

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Feature

Biotech's pale shadow

Two years after the biotech industry was called out on gender imbalance, the lack of racial diversity in the workforce is largely being ignored.

Brady Huggett

Collection:

Achieving diversity in Research
Feature 18 Dec 2017

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Patents

Mapping the global influence of published research on industry and innovation

Measuring citations to scholarly works in the global patent literature enables assessment of the influence of published research on invention, industry and enterprise, at the individual and institutional level.

Osmat A Jefferson
Adam Jaffe
Richard A Jefferson
Patents Open Access 10 Jan 2018
Recent patents in proteomics

Patents 10 Jan 2018

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News & Views

Strength in numbers from integrated single-cell neuroscience

Combining epigenomics and transcriptomics data from human brain samples reveals regulatory mechanisms that underlie cell type identity.

Rahul Satija
News & Views 10 Jan 2018
Viruses leave their stamp on single cells

A method for 'stamping' viruses achieves efficient transduction of single target cells in cultured tissues and in the mouse brain.

Ede A Rancz
Andreas T Schaefer
News & Views 18 Dec 2017
RNA-targeting CRISPR comes of age

Cas13 can be harnessed for RNA knockdown and editing in mammalian cells, opening up a range of applications in RNA biology.

V Narry Kim
News & Views 10 Jan 2018
Research Highlights

News & Views 10 Jan 2018

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Review Article

Precision oncology in the age of integrative genomics

Chandan Kumar-Sinha and Arul Chinnaiyan summarize the increasing use of sequencing panels to screen for cancer-associated genes in tumor and germline samples. The authors highlight the increasing appreciation of aberrations in regulatory genes or chromatin-related genes and argue that precision oncology must be considered in the context of adding value to the standard of care, not apart from it.

Chandan Kumar-Sinha
Arul M Chinnaiyan
Review Article 10 Jan 2018

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Article

Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation

Similar bacterial species and strains in metagenomes are resolved and linked to the plasmids that they harbor using DNA methylation analysis.

John Beaulaurier
Shijia Zhu
Gang Fang
Article 11 Dec 2017
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

Single-cell analysis of the adult human brain is facilitated by improved methods for RNA-seq and hypersensitive-site mapping.

Blue B Lake
Song Chen
Kun Zhang
Article 11 Dec 2017
Virus stamping for targeted single-cell infection in vitro and in vivo

Viruses are transduced to single cells in tissues, organoids and in the mouse brain using mechanical carriers.

Rajib Schubert
Stuart Trenholm
Botond Roska
Article 18 Dec 2017
Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

Droplet single-cell RNA-seq is applied to large numbers of pooled samples from unrelated individuals.

Hyun Min Kang
Meena Subramaniam
Chun Jimmie Ye
Article 11 Dec 2017

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Letter

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency

Modulation of DNA repair pathway choice by a potent inhibitor of 53BP1 improves the efficiency of homology-dependent genome editing in human and mouse cells.

Marella D Canny
Nathalie Moatti
Daniel Durocher
Letter 27 Nov 2017

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Resource

Global landscape of cell envelope protein complexes in Escherichia coli

A survey of cell envelope proteins and their interacting partners in E. coli by mass spectrometry reveals insights into essential bacterial processes.

Mohan Babu
Cedoljub Bundalovic-Torma
Andrew Emili
Resource 27 Nov 2017

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Careers and Recruitment

Mentoring for diversity in technology

Psychosocial mentoring for both students and managers can help people from different backgrounds develop into a team and a community.

Maggie Werner-Washburne

Collection:

Achieving diversity in Research
Careers and Recruitment 18 Dec 2017
People

Careers and Recruitment 10 Jan 2018

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Volume 36 Issue 1, January 2018

Editorial

News

News Feature

Correspondence

Feature

Patents

News & Views

Review Article

Article

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