A House panel's witch hunt against fetal tissue research demands a forceful response from the biomedical community.
Volume 34 Issue 5, May 2016
Immuno-oncology was hotly pursued by investors in 2015, along with drug delivery platforms. In the agbiotech world, a systems biology company set up shop.
Current regulatory regimes for genetically engineered crops fail to use a scientifically defensible approach or tailor the degree of regulatory review to the level of actual hazard or risk. We describe a rational way forward.
Knowledge-sharing strategies differ depending on the nature of the research objectives of public–private partnerships, but information about such strategies is often vague.
News & Views
A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule through that pore. With the development of enzyme-based methods that ratchet polynucleotides through the nanopore, nucleobase-by-nucleobase, measurements of changes in the current through the pore can now be decoded into a DNA sequence using an algorithm. In this Historical Perspective, we describe the key steps in nanopore strand-sequencing, from its earliest conceptualization more than 25 years ago to its recent commercialization and application.
Multiple chromosomal sites are readily labeled using Cas9 and guide RNAs that bind fluorescent proteins, enabling visualization of chromatin dynamics.
Human disease genetics is extended to the identification of individuals who remain healthy despite carrying highly penetrant disease-causing mutations.
Complementary genomic features associated with pathway activation, gene dependency and drug sensitivity are uncovered using REVEALER.
Circulating tumor DNA is detected with high sensitivity and specificity using molecular barcoding and in silico error correction.
Energy- and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions
A wide array of functionalized small molecules can be synthesized in Escherichia coli by engineering orthogonal, modular pathways that are energy and carbon efficient.
Sequencing wild and cultivated cassava and related species reveals extensive interspecific hybridization and genetic diversity
The global genetic diversity of cassava and related Manihot species is revealed by sequencing of 53 cultivated and wild accessions and genotyping of 268 African cassavas, providing a vital resource for breeding.