Volume 32 Issue 5, May 2014

Volume 32 Issue 5

Pollarded tree representing pruned glycan structures. Meuris et al. describe a glycoengineering strategy that simplifies the N-glycosylation pathway, resulting in the expression of proteins with short, less heterogeneous glycans (p 485). Credit: Mary Muers

Editorial

  • Editorial |

    The commencement of human trials of a gene therapy delivering HIV-neutralizing antibodies is a welcome addition to efforts to develop conventional vaccines against this scourge.

  • Editorial |

    Orphan drug development is already difficult enough. Demanding manufacturers account for the development costs of individual drugs for reimbursement is misguided.

News

Data Page

News Feature

  • News Feature |

    What is the secret sauce for a successful biotech company drug launch in 2014? Melanie Senior investigates.

Bioentrepreneur

  • Bioentrepreneur |

    How to build powerful translational research centers.

    • Matthew Grunseth
    • , Calvin Chen
    • , Ryan Kelly
    • , Sangeeta Bardhan Cook
    • , George Megaw
    •  & Larry Couture

Correspondence

Feature

Patents

News & Views

  • News & Views |

    The goal of characterizing solid-tumor genomes with nothing more than a blood sample is now within reach.

    • Michael R Speicher
    •  & Klaus Pantel
  • News & Views |

    Reducing the glycan heterogeneity of recombinant proteins may improve the efficacy of biopharmaceuticals.

    • Bernd Lepenies
    •  & Peter H Seeberger
  • News & Views |

    Incorporation of a new unnatural amino acid during protein synthesis enables proteomic profiling of specific cell types in whole animals.

    • Tao Peng
    •  & Howard C Hang

Commentary

  • Commentary |

    Metabolic reconstructions remain limited in their scope and content, and improvements in biochemical knowledge and collaborative research are required.

    • Jonathan Monk
    • , Juan Nogales
    •  & Bernhard O Palsson

Review Article

  • Review Article |

    Jeck and Sharpless review recent advances in sequencing, bioinformatics and biochemical analyses that have uncovered numerous circular RNA transcripts in mammalian cells.

    • William R Jeck
    •  & Norman E Sharpless

Brief Communication

Article

Letter

  • Letter |

    Whole-exome sequencing of circulating tumor cells enables accurate and powered calling of somatic point mutations.

    • Jens G Lohr
    • , Viktor A Adalsteinsson
    • , Kristian Cibulskis
    • , Atish D Choudhury
    • , Mara Rosenberg
    • , Peter Cruz-Gordillo
    • , Joshua M Francis
    • , Cheng-Zhong Zhang
    • , Alex K Shalek
    • , Rahul Satija
    • , John J Trombetta
    • , Diana Lu
    • , Naren Tallapragada
    • , Narmin Tahirova
    • , Sora Kim
    • , Brendan Blumenstiel
    • , Carrie Sougnez
    • , Alarice Lowe
    • , Bang Wong
    • , Daniel Auclair
    • , Eliezer M Van Allen
    • , Mari Nakabayashi
    • , Rosina T Lis
    • , Gwo-Shu M Lee
    • , Tiantian Li
    • , Matthew S Chabot
    • , Amy Ly
    • , Mary-Ellen Taplin
    • , Thomas E Clancy
    • , Massimo Loda
    • , Aviv Regev
    • , Matthew Meyerson
    • , William C Hahn
    • , Philip W Kantoff
    • , Todd R Golub
    • , Gad Getz
    • , Jesse S Boehm
    •  & J Christopher Love

Careers and Recruitment