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Pollarded tree representing pruned glycan structures. Meuris et al. describe a glycoengineering strategy that simplifies the N-glycosylation pathway, resulting in the expression of proteins with short, less heterogeneous glycans (p 485). Credit: Mary Muers
The commencement of human trials of a gene therapy delivering HIV-neutralizing antibodies is a welcome addition to efforts to develop conventional vaccines against this scourge.
Orphan drug development is already difficult enough. Demanding manufacturers account for the development costs of individual drugs for reimbursement is misguided.
Metabolic reconstructions remain limited in their scope and content, and improvements in biochemical knowledge and collaborative research are required.
Jeck and Sharpless review recent advances in sequencing, bioinformatics and biochemical analyses that have uncovered numerous circular RNA transcripts in mammalian cells.
By incorporating unnatural amino acids into proteins, Elliott et al. label, image and identify proteins in specific cells in a developing fly under physiological conditions.
