Volume 32 Issue 3, March 2014

Volume 32 Issue 3

The dorsal root ganglion of a mouse injected intrasciatically with a virus encoding a light-sensitive opsin (green); nociceptive markers are shown in blue and red. Iyer et al. use optogenetics to control pain in freely moving nontransgenic mice (p 274). Credit: Shrivats Iyer and Kate Montgomery.

Editorial

  • Editorial |

    Renewed investor interest in RNA interference (RNAi) is enabling pioneering companies to forge ahead in the clinic. Does this signify a renaissance in RNAi therapy?

News

Correction

Bioentrepreneur

Correspondence

Commentary

Feature

  • Feature |

    Ventures focusing on gene therapy, adoptive T-cell therapy, protein homeostasis and the microbiome are among those selected by the editors in 2013's crop of startups.

    • Aaron Bouchie
    • , Malorye Allison
    • , Sarah Webb
    •  & Laura DeFrancesco

Patents

News & Views

  • News & Views |

    Optogenetic methods to control nociceptors open up a wealth of potential applications in pain research and therapy.

    • Liam E Browne
    •  & Clifford J Woolf
  • News & Views |

    Combining yeast two-hybrid data with mass-spectrometry and structural data provides a detailed view of the E. coli interactome.

    • Ulrich Stelzl
  • News & Views |

    Eating foods rich in plant fiber promotes health by changing the composition and metabolic products of gut bacteria.

    • Harald Brüssow
    •  & Scott J Parkinson

Analysis

Perspective

Article

Letter

Resource

  • Resource |

    Yeast-two hybrid screening of E. coli proteins and integration with protein structure and genetic interaction data provides an extensive interactome resource.

    • Seesandra V Rajagopala
    • , Patricia Sikorski
    • , Ashwani Kumar
    • , Roberto Mosca
    • , James Vlasblom
    • , Roland Arnold
    • , Jonathan Franca-Koh
    • , Suman B Pakala
    • , Sadhna Phanse
    • , Arnaud Ceol
    • , Roman Häuser
    • , Gabriella Siszler
    • , Stefan Wuchty
    • , Andrew Emili
    • , Mohan Babu
    • , Patrick Aloy
    • , Rembert Pieper
    •  & Peter Uetz

Corrigendum

Erratum

Corrigendum

Careers and Recruitment

  • Careers and Recruitment |

    Healthcare's reform era is here, requiring executives in the life sciences industry to think differently about their skill sets and capabilities.

    • John McLean
  • Careers and Recruitment |