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The dorsal root ganglion of a mouse injected intrasciatically with a virus encoding a light-sensitive opsin (green); nociceptive markers are shown in blue and red. Iyer et al. use optogenetics to control pain in freely moving nontransgenic mice (p 274). Credit: Shrivats Iyer and Kate Montgomery.
Renewed investor interest in RNA interference (RNAi) is enabling pioneering companies to forge ahead in the clinic. Does this signify a renaissance in RNAi therapy?
The spectacular performance of biopharma companies in the public markets last year has carried over into optimism for early 2014. Will the boom continue?
Ventures focusing on gene therapy, adoptive T-cell therapy, protein homeostasis and the microbiome are among those selected by the editors in 2013's crop of startups.
Zook et al. describe methods for integrating genome variants from five sequencing technologies to characterize the first benchmark sample that can be used to understand accuracy of human whole-genome and targeted sequencing.
Haplotyping of human genomes is improved by augmenting experimental dilution-based haplotyping with statistical analyses, a strategy known until now only as 'Moleculo.'
Yeast-two hybrid screening of E. coli proteins and integration with protein structure and genetic interaction data provides an extensive interactome resource.