Volume 32 Issue 1, January 2014

Volume 32 Issue 1

Soybean aphid nymphs (Aphis glycines) navigating trichomes on the underside of a soybean leaf. Bonning et al. use a plant virus coat protein to deliver an insect-specific neurotoxin from the aphid gut into the body cavity, providing a new strategy for managing sap-sucking agricultural pests (p 102). Credit: Greg VanNostrand

Editorial

  • Editorial |

    The US Food and Drug Administration (FDA) must clarify how it intends to enforce device regulation on direct-to-consumer (DTC) services that offer to interpret genome variation.

News

News Feature

  • News Feature |

    A growing market for therapeutic drugs to treat pets is fostering a startup boom. Gunjan Sinha reports.

    • Gunjan Sinha

Bioentrepreneur

  • Bioentrepreneur |

    Fundraising is an integral part of almost every young biotech's business strategy, yet many entrepreneurs do not have a systematic approach for identifying and prioritizing potential investors—many of whom work outside of traditional venture capital.

    • Dennis Ford
    •  & Barbara Nelsen

Correspondence

Commentary

  • Commentary |

    Regulatory fallout from a scandal surrounding the fabrication of data used to support a molecular test in a Duke University cancer trial is exacting an unjustifiable toll not only on health economics but also on patient lives.

    • Razelle Kurzrock
    • , Hagop Kantarjian
    •  & David J Stewart

Feature

  • Feature |

    Biologics sales grew at an incredible rate during the past 18 months, especially when compared with pharmaceuticals. But with pressure on pricing and biosimilars looming, how long will it be until biologics' last hurrah?

    • Saurabh (Rob) Aggarwal
  • Feature |

    The most comprehensive survey of clinical success rates across the drug industry to date shows productivity may be even lower than previous estimates.

    • Michael Hay
    • , David W Thomas
    • , John L Craighead
    • , Celia Economides
    •  & Jesse Rosenthal
  • Feature |

    Compared with other US public-sector research institutions, the US National Institutes of Health has contributed inventions that have had a disproportionately greater impact on the overall number of products produced, drugs granted orphan status and drugs granted priority review.

    • Sabarni K Chatterjee
    •  & Mark L Rohrbaugh

Patents

News & Views

  • News & Views |

    Transient treatment of diabetic mice with two cytokines induces acinar-to-beta-cell conversion to an extent sufficient to durably restore normoglycemia.

    • Hannah N Worchel
    •  & Mark A Magnuson
  • News & Views |

    Fusion of a viral coat protein to an insect-specific neurotoxin delivers the molecule into aphids where it is insecticidal.

    • Anna E Whitfield
    • , Dorith Rotenberg
    •  & Thomas L German
  • News & Views |

    Wiser use of antibiotics could help combat the emergence of drug-resistant pathogens.

    • Robert E W Hancock
  • News & Views |

    Human pluripotent stem cells can be stabilized in a state resembling the inner cell mass of the blastocyst.

    • Victoria L Mascetti
    •  & Roger A Pedersen

Analysis

Article

Letter

Careers and Recruitment

  • Careers and Recruitment |

    Systematic attention is required to confront the challenges faced by life scientists in interdisciplinary professions in India.

    • Gayatri Saberwal
  • Careers and Recruitment |