Nature Biotechnology

Volume 32 Issue 11, November 2014

Polychromatic scanning electron micrograph of the edge of a blood clot that has formed on the surface of a biomaterial. Leslie et al. describe a surface coating for medical devices that prevents the formation of this type of surface-mediated thrombosis. Credit: James Weaver and Anna Waterhouse

Volume 32 Issue 11

Editorial

Outpaced by an outbreak

The international community's woeful response to the West African Ebola epidemic has been compounded by the lack of vaccines and therapies on the ground. That is why US government cutbacks to biodefense funding should be reevaluated and five-year funding tranches restored.

Editorial 07 Nov 2014

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News

Landmark approvals in idiopathic pulmonary fibrosis

Mark Ratner
News 07 Nov 2014
Takeda's second bet on DARTs

News 07 Nov 2014
Gilead's interferon-free HCV combo approved

News 07 Nov 2014
$675 million for MRSA antibiotic

News 07 Nov 2014
Novo sets sights on obesity market with diabetes drug

Cormac Sheridan
News 07 Nov 2014
Dow's newly approved Enlist fights superweeds

News 07 Nov 2014
J&J buys antiviral firm Alios

News 07 Nov 2014
Illumina, Thermo Fisher build consortia to develop 'universal' cancer tests

Chris Morrison
News 07 Nov 2014

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Correction

Correction

Correction 07 Nov 2014

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News

Anti-IL-5 biologics carve out severe-asthma niche

Elie Dolgin
News 07 Nov 2014
Mouse mAb patent revoked

News 07 Nov 2014
EMA adopts transparency policy

News 07 Nov 2014
Australia upholds BRCA1 gene patent

News 07 Nov 2014
Big-cap buying bonanza trickles down to small biotech

Melanie Senior
News 07 Nov 2014

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Data Page

Biotech on the bounce in 3Q14

Walter Yang
Data Page 07 Nov 2014
Drug pipeline 3Q14

Laura DeFrancesco
Data Page 07 Nov 2014

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News Feature

Technology comes to typing

As mass spectrometry makes inroads into pathogen identification in the clinical laboratory, deep sequencing—even nanopore sequencing—is waiting in the wings. Jeffrey L. Fox investigates.

Jeffrey L Fox
News Feature 07 Nov 2014

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Data Page

Top US universities and institutes for life sciences in 2013

Brady Huggett
Data Page 07 Nov 2014

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Correspondence

3D printing for the many, not the few

James N Fullerton
George C M Frodsham
Richard M Day
Correspondence 07 Nov 2014
Genetically engineered crops that fly under the US regulatory radar

Alex Camacho
Allen Van Deynze
Alan B Bennett
Correspondence 07 Nov 2014
Screening cellular metabolic activity

Bachir el Debs
Ramesh Utharala
Christoph A Merten
Correspondence 07 Nov 2014
Gregory Stephanopoulos and colleagues reply to Screening cellular metabolic activity

Bachir el Debs
Ramesh Utharala
Christoph A Merten
Correspondence 07 Nov 2014

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Patents

Antibody claims granted by the European Patent Office

A survey of the claims of antibody-related patents granted by the European Patent Office and a review of the type and scope of product claims granted for antibodies.

Hilary van der Hoff
Patents 07 Nov 2014
Recent patent applications in neural engineering

Patents 07 Nov 2014

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News & Views

Closing in on pancreatic beta cells

Differentiation of human pluripotent stem cells toward pancreatic beta cells yields cells of increased maturity.

Neil Hanley

Collection:

Stem cells in translation
News & Views 07 Nov 2014
Antibacterials for any target

RNA-guided nucleases provide a strategy for killing specific bacterial species in complex populations.

Lynn L Silver
News & Views 07 Nov 2014
Making biology transparent

The molecular and cellular architecture of the organs in a whole mouse is revealed through optical clearing.

Burkhard Höckendorf
Luke D Lavis
Philipp J Keller
News & Views 07 Nov 2014

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Analysis

Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads

A new approach overcomes the hurdles of identifying large, complex structural variants in cancer genomes by directly comparing tumor and normal genome sequencing reads.

Valentí Moncunill
Santi Gonzalez
David Torrents
Analysis 26 Oct 2014

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Perspective

Allosteric targeting of receptor tyrosine kinases

Frederik De Smet
Arthur Christopoulos
Peter Carmeliet
Perspective 07 Nov 2014

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Article

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

A seven-stage protocol enables differentiation of human embryonic stem cells into cells similar to pancreatic beta cells.

Alireza Rezania
Jennifer E Bruin
Timothy J Kieffer

Collection:

Stem cells in translation
Article 11 Sept 2014
A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

A non-stick surface coating makes medical devices anti-thrombogenic and resistant to biofilm growth.

Daniel C Leslie
Anna Waterhouse
Donald E Ingber
Article 12 Oct 2014

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Letter

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

Delivery of CRISPR-Cas nucleases using bacteriophage enables targeted killing of microbes in a population

Robert J Citorik
Mark Mimee
Timothy K Lu

Collection:

Antimicrobial Resistance
Letter 21 Sept 2014
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

Coupling the specificity of CRISPR-Cas nucleases and bacteriophage delivery enables exquisitely precise bacterial killing.

David Bikard
Chad W Euler
Luciano A Marraffini

Collection:

Antimicrobial Resistance
Letter 05 Oct 2014
Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells

Endothelial cells with properties of cord-blood endothelial colony-forming cells are generated from human pluripotent stem cells.

Nutan Prasain
Man Ryul Lee
Mervin C Yoder

Collection:

Stem cells in translation
Letter 12 Oct 2014

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Resource

Comparative analyses of C₄ and C₃ photosynthesis in developing leaves of maize and rice

Efforts to improve the efficiency of photosynthesis in crop plants will benefit from a resource of transcriptomic and metabolomic data on maize and rice.

Lin Wang
Angelika Czedik-Eysenberg
Thomas P Brutnell
Resource 12 Oct 2014

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Erratum

Erratum: Multi-platform assessment of transcriptome profiling using RNA-seq in the ABRF next-generation sequencing study

Sheng Li
Scott W Tighe
Christopher E Mason
Erratum 07 Nov 2014
Erratum: High-resolution metagenomics

Eran Mick
Rotem Sorek
Erratum 07 Nov 2014
Erratum: Public biotech 2013—the numbers

Stacy Lawrence
Riku Lahteenmaki
Erratum 07 Nov 2014

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Corrigendum

Correction: Corrigendum: Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells

Peter W Andrews
Joy Cavanagro
Shinya Yamanaka
Corrigendum 07 Nov 2014

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Careers and Recruitment

Third-quarter biotech job picture

Michael Francisco
Careers and Recruitment 07 Nov 2014
People

Careers and Recruitment 07 Nov 2014

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