Volume 31 Issue 9, September 2013

Heat maps of the specificity of DNA cleavage by RNA-guided Cas9 endonuclease. Four groups use a variety of methods in vitro and in cells to assess the specificity of genome editing with CRISPR-Cas systems (pp 822, 827, 833, 839). Credit: Marina Spence, based on images provided by David Liu, Prashant Mali and Feng Zhang.

Editorial

Contrary to popular belief

Three decades after transgenes were first introduced into plants, why do so many consumers remain so negative about genetically modified (GM) food?

Editorial 10 Sept 2013

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News

J&J courts biotech in clusters

Melanie Senior
News 10 Sept 2013
Doubts raised over 'read-through' Duchenne drug mechanism

Cormac Sheridan
News 10 Sept 2013
Swedish deals surge

Gunjan Sinha
News 10 Sept 2013

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Correction

Correction

Correction 10 Sept 2013

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News

Synthetic biology goes industrial

Jennifer Rohn
News 10 Sept 2013
Europe's first copy-cat antibody

Emma Dorey
News 10 Sept 2013
Amgen best-seller challenged by generics

Mark Ratner
News 10 Sept 2013
iPS cells in humans

David Cyranoski
News 10 Sept 2013
First Axl inhibitor enters clinical trials

Cormac Sheridan
News 10 Sept 2013
Monsanto waves white flag

Anna Meldolesi
News 10 Sept 2013
Forma skips tech transfer brokers

Nuala Moran
News 10 Sept 2013
Greenpeace campaign prompts Philippine ban on Bt eggplant trials

Lucas Laursen
News 10 Sept 2013
Around the world in a month

News 10 Sept 2013
Biotechs to tap into Horizon 2020's $93 billion

Nuala Moran
News 10 Sept 2013

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Data Page

Drug pipeline 2Q13

Laura DeFrancesco
Data Page 10 Sept 2013

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News Feature

At the frontiers of lung fibrosis therapy

Despite recent failures, a flurry of activity in biotech and pharma is raising hopes that an effective drug for this fatal lung disease is on the way. Ken Garber investigates.

News Feature 10 Sept 2013

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Bioentrepreneur

Top 20 translational researchers in 2012

Brady Huggett
Kathryn Paisner
Bioentrepreneur 10 Sept 2013

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Correspondence

Falling prices and unfair competition in consumer genomics

Ruslan Dorfman
Correspondence 10 Sept 2013
The ethics of participant-led biomedical research

Effy Vayena
John Tasioulas
Correspondence 10 Sept 2013
Systematic investigation of cancer-associated somatic point mutations in SNP databases

HyunChul Jung
Thomas Bleazard
Dongwan Hong
Correspondence 10 Sept 2013
Economic and environmental impacts of microbial biodiesel

Luis Caspeta
Jens Nielsen
Correspondence 10 Sept 2013

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Feature

How safe does transgenic food need to be?

Disputes over how to assess a foodstuff's safety continue to play into public fears about transgenic crops.

Laura DeFrancesco
Feature 10 Sept 2013

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Patents

Maximizing the commercial value of personalized therapeutics and companion diagnostics

Creating an intellectual property strategy that matches the co-development model and is tailored to the specific drug-diagnostic pair is essential to success.

Cynthia H Zhang
Y Philip Zhang
Patents 10 Sept 2013
Recent patent applications in diagnostics

Patents 10 Sept 2013

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News & Views

Staying on target with CRISPR-Cas

Four independent studies shed light on the specificity of RNA-guided genome editing tools based on the Streptococcus pyogenes Cas9 protein.

Dana Carroll
News & Views 10 Sept 2013
Cages from coils

The use of coiled coils could facilitate the modular, predictable design of protein nanocages.

Bryan S Der
Brian Kuhlman
News & Views 10 Sept 2013
Research Highlights

News & Views 10 Sept 2013
Programming CMV for vaccine vector design

Viral vectors that elicit CD8 T-cell responses of unprecedented breadth and promiscuity may aid the design of improved HIV vaccines.

Srinika Ranasinghe
Bruce D Walker
News & Views 10 Sept 2013
Commensal cocktail suppresses gut inflammation

Christine Borowski
News & Views 10 Sept 2013

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Analysis

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences

The functional composition of microbial community samples from several environments is predicted based on 16S ribosomal RNA gene sequencing data.

Morgan G I Langille
Jesse Zaneveld
Curtis Huttenhower

Collection:

Computational Biology
Analysis 25 Aug 2013

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Letter

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

CAS9 nucleases, a new tool for genome editing, show significant offtarget activity.

Yanfang Fu
Jennifer A Foden
Jeffry D Sander

Collection:

Nobel Prize in Chemistry 2020
Letter 23 Jun 2013
DNA targeting specificity of RNA-guided Cas9 nucleases

Analyses of the determinants of the specificity of Cas9 nuclease provide rules for selecting optimal target sites.

Patrick D Hsu
David A Scott
Feng Zhang

Collection:

Nobel Prize in Chemistry 2020
Letter 21 Jul 2013
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

A screen in human cells defines the targeting specificities of sgRNA:Cas9 and TAL-based transcriptional activators.

Prashant Mali
John Aach
George M Church
Letter 01 Aug 2013
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

In vitro selection and high-throughput sequencing measure the sequence specificity of cleavage by gRNA-Cas9 complexes.

Vikram Pattanayak
Steven Lin
David R Liu
Letter 11 Aug 2013
MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

A strategy exploiting species-specific miRNA expression may provide another layer of biosafety in gain-of-function influenza experiments.

Ryan A Langlois
Randy A Albrecht
Benjamin R tenOever
Letter 11 Aug 2013
Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching

Overexpression of a microRNA in rice increases yield, suggesting new routes to crop improvement.

Yu-Chan Zhang
Yang Yu
Yue-Qin Chen
Letter 21 Jul 2013

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Careers and Recruitment

An interdisciplinary shift in demand for talent within the biotech industry

A shift away from hiring narrowly focused specialists to individuals with interdisciplinary academic training highlights the latest life sciences workforce trends.

Kathy L Nugent
Avi Kulkarni
Careers and Recruitment 10 Sept 2013
People

Careers and Recruitment 10 Sept 2013

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Volume 31 Issue 9, September 2013

Editorial

News

Correction

News

Data Page

News Feature

Bioentrepreneur

Correspondence

Feature

Patents

News & Views

Analysis

Letter

Careers and Recruitment

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