Volume 31 Issue 7, July 2013

Editorial

Myriad diagnostic concerns

The Myriad decision to overturn human gene patents is the least of concerns for a diagnostic sector struggling to attract investment.

Editorial 09 Jul 2013

Advertisement

Top of page ⤴

News

Thermo Fisher vies for Life Technologies' sequencing market

Mark Ratner
News 09 Jul 2013
cDNA is patentable, but not genes

Mark Ratner
News 09 Jul 2013
Investors start backing hearing loss treatments

Cormac Sheridan
News 09 Jul 2013
Innovators under 36, please

Lisa Melton
News 09 Jul 2013
First microRNA mimic enters clinic

Aaron Bouchie
News 09 Jul 2013
India blacklisted

Killugudi Jayaraman
News 09 Jul 2013
Crowdsourced contest identifies best-in-class breast cancer prognostic

Michael Eisenstein
News 09 Jul 2013
GSK shares spoils with Avalon

Brian Orelli
News 09 Jul 2013
Argentina cuts GM red tape

Lucas Laursen
News 09 Jul 2013
Court injunction threatens clinical data transparency push

Nuala Moran
News 09 Jul 2013
Around the world in a month

News 09 Jul 2013
Fecal transplants to follow FDA rules

Jeffrey L Fox
News 09 Jul 2013

Top of page ⤴

Obituary

Willem 'Pim' Stemmer 1957–2013

A truly original thinker and pioneering entrepreneur.

James W Larrick
Volker Schellenberger
Carlos F Barbas III
Obituary 09 Jul 2013

Top of page ⤴

News Feature

Banking on cord blood stem cells

New research will shed light on claims from commercial banks that cord blood–derived stem cells can be used in diseases beyond hematological disorders. Sarah Webb investigates.

Sarah Webb
News Feature 09 Jul 2013

Top of page ⤴

Bioentrepreneur

University biotech patenting

Brady Huggett
Bioentrepreneur 09 Jul 2013

Top of page ⤴

Correspondence

The case for semi-mandatory HPV vaccination in China

Wen Jie Zhang
Feng Li
Yu Guang Cao
Correspondence 09 Jul 2013
Rapid growth of seaweed biotechnology provides opportunities for developing nations

Inés Mazarrasa
Ylva S Olsen
Carlos M Duarte
Correspondence 09 Jul 2013
Read and assembly metrics inconsequential for clinical utility of whole-genome sequencing in mapping outbreaks

Simon R Harris
M E Török
Julian Parkhill
Correspondence 09 Jul 2013

Top of page ⤴

Feature

Genomic testing reaches into the womb

Next-generation sequencing has provided long-sought-after noninvasive tests for prenatal screening, and a small cadre of companies has stepped up to push it into the clinic at warp speed.

Malorye Allison
Feature 09 Jul 2013

Top of page ⤴

Patents

Bowman v. Monsanto and the protection of patented replicative biologic technologies

An important US Supreme Court ruling means that prudent owners, end users and other courts will proceed with caution.

William J Simmons
Patents 01 Jul 2013
Recent patent applications in hematopoietic stem cells

Patents 09 Jul 2013

Top of page ⤴

News & Views

Cracking the code of human T-cell immunity

Combinatorial tetramer staining coupled with mass cytometry allows simultaneous detection of T cells specific for a wide array of peptide epitopes.

Christopher J Harvey
Kai W Wucherpfennig
News & Views 09 Jul 2013
A window onto siRNA delivery

Two studies trace the intracellular trafficking of siRNA delivered by lipid nanoparticles.

Yuhua Wang
Leaf Huang
News & Views 09 Jul 2013
Research Highlights

News & Views 09 Jul 2013
Organic synthesis by in vitro evolution

A method for DNA-templated ligation allows in vitro evolution of organic polymers.

Peter E Nielsen
News & Views 09 Jul 2013

Top of page ⤴

Analysis

Uniform, optimal signal processing of mapped deep-sequencing data

Optimized algorithms from the field of electrical-signal processing improve the identification of genomic signals from diverse high-throughput sequencing experiments, such as ChIP-seq, DNase-seq and FAIRE-seq.

Vibhor Kumar
Masafumi Muratani
Shyam Prabhakar
Analysis 16 Jun 2013

Top of page ⤴

Article

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization

An approach involving combinatorial peptide–MHC tetramer staining and mass cytometry allows simultaneous screening of over 100 T-cell specificities in a single human blood sample.

Evan W Newell
Natalia Sigal
Mark M Davis
Article 09 Jun 2013
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

The sensitivity of chaperones to the stability of client proteins is used for kinome-wide profiling of kinase inhibitors.

Mikko Taipale
Irina Krykbaeva
Susan Lindquist
Article 30 Jun 2013
Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape.

Jerome Gilleron
William Querbes
Marino Zerial
Article 23 Jun 2013

Top of page ⤴

Letter

Broad protection against influenza infection by vectored immunoprophylaxis in mice

Gene therapy encoding a single influenza broadly neutralizing antibody durably protects even immunocompromised mice from illness caused by diverse influenza strains.

Alejandro B Balazs
Jesse D Bloom
David Baltimore
Letter 02 Jun 2013
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape.

Gaurav Sahay
William Querbes
Daniel G Anderson
Letter 23 Jun 2013

Top of page ⤴

Careers and Recruitment

Mentors, be nice

Mentors are essential for the training of PhDs and fellows, but many have lost sight of positive leadership and are just mean.

Nathan L Vanderford

Career Guide:

Mentoring resources for scientists
Careers and Recruitment 09 Jul 2013
People

Careers and Recruitment 09 Jul 2013

Top of page ⤴

Volume 31 Issue 7, July 2013

Editorial

News

Obituary

News Feature

Bioentrepreneur

Correspondence

Feature

Patents

News & Views

Analysis

Article

Letter

Careers and Recruitment

Search

Quick links