Volume 31 Issue 5, May 2013

Volume 31 Issue 5

A bacterial cell endowed with logic and memory. Siuti et al. open new doors for cellular engineering by synthesizing genetic circuits whose function depends on past and present inputs (p 448). Credit: Liang Zong and Yan Liang (l2xy2.com).

Editorials

  • Editorial |

    Judicious choice of a target tumor antigen for adoptive T-cell therapy remains crucial not only for efficacy but also for avoiding serious toxicities.

  • Editorial |

    Nature Biotechnology and other Nature journals are updating editorial policies with the aim of improving transparency and reproducibility.

News

Bioentrepreneur

Opinion and Comment

Features

News and Views

  • News & Views |

    Myelinating oligodendrocytes are induced from murine embryonic fibroblasts by transcription factor–mediated reprogramming.

    • Steven A Goldman
  • News & Views |

    Genetic circuits that process and permanently store information are created with recombinases that flip the orientation of DNA cassettes.

    • Andre C Maranhao
    •  & Andrew D Ellington
  • News & Views |

    New work fuels the controversy over the role of reactive oxygen species (ROS) in the activity of bactericidal antibiotics.

    • Ferric C Fang
  • News & Views |

    New insights into hemogenic endothelium will facilitate efforts to produce hematopoietic stem cells in vitro.

    • Christopher M Sturgeon
    • , Andrea Ditadi
    • , Raedun L Clarke
    •  & Gordon Keller

Computational Biology

    Resource

  • Resource |

    The metabolic modeling community has curated information from five models to create the most comprehensive model of human metabolism to date.

    • Ines Thiele
    • , Neil Swainston
    • , Ronan M T Fleming
    • , Andreas Hoppe
    • , Swagatika Sahoo
    • , Maike K Aurich
    • , Hulda Haraldsdottir
    • , Monica L Mo
    • , Ottar Rolfsson
    • , Miranda D Stobbe
    • , Stefan G Thorleifsson
    • , Rasmus Agren
    • , Christian Bölling
    • , Sergio Bordel
    • , Arvind K Chavali
    • , Paul Dobson
    • , Warwick B Dunn
    • , Lukas Endler
    • , David Hala
    • , Michael Hucka
    • , Duncan Hull
    • , Daniel Jameson
    • , Neema Jamshidi
    • , Jon J Jonsson
    • , Nick Juty
    • , Sarah Keating
    • , Intawat Nookaew
    • , Nicolas Le Novère
    • , Naglis Malys
    • , Alexander Mazein
    • , Jason A Papin
    • , Nathan D Price
    • , Evgeni Selkov Sr
    • , Martin I Sigurdsson
    • , Evangelos Simeonidis
    • , Nikolaus Sonnenschein
    • , Kieran Smallbone
    • , Anatoly Sorokin
    • , Johannes H G M van Beek
    • , Dieter Weichart
    • , Igor Goryanin
    • , Jens Nielsen
    • , Hans V Westerhoff
    • , Douglas B Kell
    • , Pedro Mendes
    •  & Bernhard Ø Palsson

Research

Careers and Recruitment