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Volume 31 Issue 5, May 2013

A bacterial cell endowed with logic and memory. Siuti et al. open new doors for cellular engineering by synthesizing genetic circuits whose function depends on past and present inputs (p 448). Credit: Liang Zong and Yan Liang (l2xy2.com).

Editorial

  • Judicious choice of a target tumor antigen for adoptive T-cell therapy remains crucial not only for efficacy but also for avoiding serious toxicities.

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  • Nature Biotechnology and other Nature journals are updating editorial policies with the aim of improving transparency and reproducibility.

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  • Better understanding of the mechanisms of action, modification and synthesis of antimicrobial peptides is reigniting commercial development. Jeffrey L. Fox reports.

    • Jeffrey L Fox
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Bioentrepreneur

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Book Review

    • Andrew Marshall
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News & Views

  • Myelinating oligodendrocytes are induced from murine embryonic fibroblasts by transcription factor–mediated reprogramming.

    • Steven A Goldman
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  • New work fuels the controversy over the role of reactive oxygen species (ROS) in the activity of bactericidal antibiotics.

    • Ferric C Fang
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  • New insights into hemogenic endothelium will facilitate efforts to produce hematopoietic stem cells in vitro.

    • Christopher M Sturgeon
    • Andrea Ditadi
    • Gordon Keller
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