Volume 31 Issue 4, April 2013

Volume 31 Issue 4

Bacteria 1 Credit: Art by Angelina Vick www.angelinavick.com

In This Issue


  • Editorial |

    Genetically defined germ-free animal models colonized with defined microbiota are crucial for progress in microbiome research.

  • Editorial |

    The brand biotech industry is erecting barriers to biosimilars that will slow market entry and torpedo price competition.



    Building a business

  • Bioentrepreneur |

    With acquisition the most likely exit for today's biotech investors, it pays to keep current with the tastes of pharmaceutical firms when launching a venture.

    • Asiya Giniatullina
    • , Marco Boorsma
    • , Geert-Jan Mulder
    •  & Sander van Deventer
  • SciCafé

Opinion and Comment


  • Feature |

    Nine experts discuss the challenges in translating current research on the human microbiome into strategies for disease prediction, diagnosis and therapy.

    • James Brown
    • , Willem M de Vos
    • , Peter S DiStefano
    • , Joël Doré
    • , Curtis Huttenhower
    • , Rob Knight
    • , Trevor D Lawley
    • , Jeroen Raes
    •  & Peter Turnbaugh
  • Feature |

    Five years after the launch of the Human Microbiome Project, several ventures are seeking to capitalize on the clinical promise of microbiome modulation. Commercialization of drugs that influence the human flora poses some unique scientific, translational and regulatory challenges.

    • Bernat Olle
  • Patents

News and Views

  • News & Views |

    siRNAs for knocking down target genes in mammalian cells can now be made in bacteria.

    • James A Blau
    •  & Michael T McManus
  • News & Views |

    The entire metabolic pathway for producing a biofuel is confined within a yeast organelle to increase yield over the endogenous pathway split between two compartments.

    • William C DeLoache
    •  & John E Dueber

Computational Biology


Careers and Recruitment

  • People

  • Careers and Recruitment |


  • Focus |

    Translating the Microbiome

    Researchers have generated more than 3.5 terabytes of human microbiome genomic information – more than 1,000 times that generated by the Human Genome Project. This Focus highlights progress in microbiome research and how these data might translate into a better understanding of human diseases and rational design of new therapies.