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Artistic rendition of DNA cleavage directed by the Cas9 endonuclease complexed with a synthetic single guide RNA. Three groups demonstrate site-specific genome modification in zebrafish embryos (p 227), human cells (p 230) and bacteria (p 233). Credit: Stephen Dixon
Increasing public and private sector cooperation to support long-term, longitudinal population studies is critical to advance translational research on complex diseases.
As industry, governments and academia increasingly rely on patent landscapes to map scientific and technological trends, an interdisciplinary workshop provides recommendations for developing consistent and transparent landscaping practices.
The MuTect algorithm for calling somatic point mutations enables subclonal analysis of the whole-genome or whole-exome sequencing data being generated in large-scale cancer genomics projects.
A CRISPR-Cas system is harnessed to introduce template-driven mutations in S. pneumoniae and E. coli at high efficiency without requiring selectable markers.
A draft sequence of the staple crop kabuli chickpea, together with resequencing and analysis of 90 additional lines from 10 countries, provides a resource for breeders.
