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Cherry and currant tomatoes of varying ripeness. Zhong et al. use whole-genome cytosine methylation and transcription factor binding analyses to show that epigenome dynamics influence the developmental transition to ripening (p 154). Credit: Ryan McQuinn
Despite their limitations, in vitro assays are a simple means for assessing the drug sensitivity of a patient's cancer. After consulting experts in the community, we think such assays deserve a second look.
FDA approvals hit a new high mark in 2012, with a December flurry of approvals. Orphan and fast-track drugs showed strong in the list. Randy Osborne reports.
A survey of stakeholders in the Indian biotech sector reveals three major challenges that will need to be addressed to spark further entrepreneurial activity.
Scientific collaborations can produce results greater than the sum of their parts, but determining who owns the IP rights to scientific results is of prime importance.
The most comprehensive analysis to date of models of transcription-factor binding specificity reveals the best methods for predicting in vivo binding from in vitro data.
Whole-genome bisulfite sequencing reveals that global reprogramming of the epigenome occurs during the maturation of tomato fruits, potentially identifying new targets for breeders.
