Volume 31 Issue 1, January 2013

Volume 31 Issue 1

A fractal-like hierarchy of network clusters extracted from the interaction networks of budding yeast. Dutkowski et al. use cellular components and processes embedded in molecular networks to derive a gene ontology (p 38). Credit: Janusz Dutkowski

Editorial

  • Editorial |

    A slew of disappointing product launches suggests biotech companies are ill prepared to navigate an increasingly parsimonious reimbursement environment.

News

Bioentrepreneur

    Building a business

  • Bioentrepreneur |

    Vacating industry and joining the academic ranks means leaving the world of order for the satisfying chaos of research.

    • John Boyle

Opinion and Comment

Feature

News and Views

  • News & Views |

    Rodent cardiomyocytes are converted into pacemaker cells by viral delivery of a single transcription-factor gene.

    • Edward G Lakatta
    •  & Victor A Maltsev
  • News & Views |

    Engineered T cells expressing two receptors distinguish malignant cells from healthy cells even in the absence of a tumor-specific antigen.

    • Ken-ichi Hanada
    •  & Nicholas P Restifo
  • News & Views |

    Manual curation of biological ontologies is recapitulated by an algorithmic approach, supplementing the Gene Ontology and enabling the discovery of relationships among genes and proteins.

    • Kara Dolinski
    •  & David Botstein

Computational Biology

    Analysis

  • Analysis |

    High-throughput network maps are used to automatically (or semi-automatically) reconstruct an ontology that recapitulates much of the Gene Ontology and finds additional terms and relations.

    • Janusz Dutkowski
    • , Michael Kramer
    • , Michal A Surma
    • , Rama Balakrishnan
    • , J Michael Cherry
    • , Nevan J Krogan
    •  & Trey Ideker

Research

Careers and Recruitment