Volume 31 Issue 12, December 2013

Volume 31 Issue 12

Artistic rendition of hyperbranched amplicons created by multiple-displacement amplification. Gole et al. uniformly amplify the DNA of single cells in nanoliter wells, enabling copynumber variants to be detected in primary human neurons (p 1126). Credit: Kun Zhang

Editorial

  • Editorial |

    Moves to give biosimilars nonproprietary names different from brand products are more than a wrangle about words—they could mean biosimilars arrive stillborn to the market.

News

News

  • News Feature

  • News Feature |

    How long will the investor exuberance driving public offerings of biotech companies last? Brady Huggett investigates.

    • Brady Huggett

Bioentrepreneur

Opinion and Comment

Feature

News and Views

  • News & Views |

    Combining genotyping and the data locked in medical records yields a large number of known genotype-phenotype associations.

    • Nigam H Shah
  • News & Views |

    Technologies developed for genome editing are repurposed to study functions of chromatin modifications.

    • Philipp Voigt
    •  & Danny Reinberg

Computational Biology

    Analysis

  • Analysis |

    When applied in large scale to electronic medical record data, the PheWAS approach replicates GWAS associations and reveals potentially new pleiotropic associations.

    • Joshua C Denny
    • , Lisa Bastarache
    • , Marylyn D Ritchie
    • , Robert J Carroll
    • , Raquel Zink
    • , Jonathan D Mosley
    • , Julie R Field
    • , Jill M Pulley
    • , Andrea H Ramirez
    • , Erica Bowton
    • , Melissa A Basford
    • , David S Carrell
    • , Peggy L Peissig
    • , Abel N Kho
    • , Jennifer A Pacheco
    • , Luke V Rasmussen
    • , David R Crosslin
    • , Paul K Crane
    • , Jyotishman Pathak
    • , Suzette J Bielinski
    • , Sarah A Pendergrass
    • , Hua Xu
    • , Lucia A Hindorff
    • , Rongling Li
    • , Teri A Manolio
    • , Christopher G Chute
    • , Rex L Chisholm
    • , Eric B Larson
    • , Gail P Jarvik
    • , Murray H Brilliant
    • , Catherine A McCarty
    • , Iftikhar J Kullo
    • , Jonathan L Haines
    • , Dana C Crawford
    • , Daniel R Masys
    •  & Dan M Roden

    Collection:

Research

Careers and Recruitment

  • Careers and Recruitment |

    The current academic culture needs to change its mission, which is narrowly focused on training PhDs to be the next generation of academic tenure-track scientists.

    • Nathan L Vanderford
  • People

  • Careers and Recruitment |

Correction

Erratum

Corrigendum