Volume 31 Issue 11, November 2013

Editorial

Receptive to replication

Do replication studies belong in top-tier journals?

Editorial 01 Nov 2013

Advertisement

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News

Drugs with breakthrough status charm investors

Melanie Senior
News 01 Nov 2013
Otsuka snaps up cancer drugmaker Astex

Alli Proffitt
News 01 Nov 2013
Biosimilars legislation state by state

News 01 Nov 2013
Newborns sequenced at NIH

Emma Dorey
News 01 Nov 2013
First-in-class anemia drug takes aim at Amgen's dominion

Aaron Bouchie
News 01 Nov 2013
Argos attracts unorthodox backers

Nuala Moran
News 01 Nov 2013
Monoclonal T-cell receptor drugs pique pharma's interest

Cormac Sheridan
News 01 Nov 2013
UCSD researcher shot by cofounder

Lucas Laursen
News 01 Nov 2013
Anti-infective monoclonals step in where antimicrobials fail

Jeffrey L Fox
News 01 Nov 2013
GM crop protection act fizzles

Emily Waltz
News 01 Nov 2013
Around the world in a month

News 01 Nov 2013

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Data Page

3Q13—IPOs continue to roar

Walter Yang
Data Page 01 Nov 2013
Drug pipeline 3Q13

Laura DeFrancesco
Data Page 01 Nov 2013

Top of page ⤴

News Feature

Vaccines for pandemics

The 2009 H1N1 pandemic showed that the egg-based technology used to produce the bulk of flu vaccine is not nimble enough to protect during a pandemic. Charles Schmidt reports on progress in synthetic and recombinant technologies that may provide an answer.

Charles Schmidt
News Feature 01 Nov 2013

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Bioentrepreneur

In search of dry powder

Which investment firms are currently actively investing in new biomedical startups?

Jonathan Behr
Phil Murray
Bioentrepreneur 01 Nov 2013

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Correspondence

Lack of detectable oral bioavailability of plant microRNAs after feeding in mice

Brent Dickinson
Yuanji Zhang
William S Marshall
Correspondence 01 Nov 2013
Reply to Lack of detectable oral bioavailability of plant microRNAs after feeding in mice

Xi Chen
Ke Zen
Chen-Yu Zhang
Correspondence 01 Nov 2013
Making the biotech IPO work

Laura McNamee
Fred Ledley
Correspondence 01 Nov 2013
Health technology assessments and innovation

Joseph Tucker
Katherine Boone
Paul Fedak
Correspondence 01 Nov 2013
The biosimilar price is right

David Gaugh
Correspondence 01 Nov 2013
Hearing loss and tinnitus—are funders and industry listening?

Christopher R Cederroth
Barbara Canlon
Berthold Langguth
Correspondence 01 Nov 2013

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Commentary

Human genetics as a foundation for innovative drug development

New technology has transformed human genetics. It now provides perhaps the single best opportunity to innovate and improve clinical success rates in drug development.

Alexander Kamb
Sean Harper
Kari Stefansson
Commentary 01 Nov 2013
Precompetitive consortia in biomedicine—how are we doing?

Too few precompetitive consortia are being formed to mitigate lost opportunities and deliver on other potential mutual gains for public and private stakeholders in drug development.

Barbara Mittleman
Garry Neil
Joel Cutcher-Gershenfeld

Nature Outlook:

Open innovation
Commentary 01 Nov 2013

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Patents

Patents and China's research and development in agricultural biotechnology

A study assesses Chinese scientists' knowledge of patents and the relationship between scientists' patent-using behaviors and their organizations' mandates.

Ruifa Hu
Xiaobing Wang
Jinyang Cai
Patents 01 Nov 2013
Recent patent applications in biomedical imaging

Patents 01 Nov 2013

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News & Views

Next-generation sequencing in the clinic

Pools of cell lines carrying a variety of known mutations are used to validate the performance of a cancer diagnostic test based on next-generation sequencing.

Jason Y Park
Larry J Kricka
Paolo Fortina
News & Views 01 Nov 2013
Two views on light sheets

A dual-view light-sheet microscope combines isotropic spatial resolution with high speed and minimal phototoxicity.

Carl G Ebeling
Erik M Jorgensen
News & Views 01 Nov 2013
Genetically encoded voltage sensor goes live

A genetically encoded voltage indicator enables robust optical recording of membrane voltage changes in the fly brain.

James H Marshel
Karl Deisseroth
News & Views 01 Nov 2013
Research Highlights

News & Views 01 Nov 2013

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Commentary

So you want to be a computational biologist?

Two computational biologists give advice when starting out on computational projects.

Nick Loman
Mick Watson
Commentary 01 Nov 2013

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Review Article

Reassessing target antigens for adoptive T-cell therapy

Christian S Hinrichs
Nicholas P Restifo
Review Article 01 Nov 2013

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Article

A single-molecule long-read survey of the human transcriptome

Sequencing the human transcriptome using long, single-molecule reads identifies new transcript isoforms.

Donald Sharon
Hagen Tilgner
Michael Snyder
Article 01 Nov 2013
Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories

RNA sequencing of 465 human lymphoblastoid cell lines across seven European laboratories shows the feasibility of transcriptome sequencing for population-wide and cross-biobank studies.

Peter A C 't Hoen
Marc R Friedländer
Tuuli Lappalainen
Article 01 Nov 2013
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

Clinical tests that rely on next-generation sequencing to evaluate large numbers of cancer genes can be validated using pooled cell lines with known mutations.

Garrett M Frampton
Alex Fichtenholtz
Roman Yelensky
Article 01 Nov 2013
Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy

A dual-view light sheet microscope allows high-speed imaging with an isotropic spatial resolution

Yicong Wu
Peter Wawrzusin
Hari Shroff
Article 01 Nov 2013
Engineering dynamic pathway regulation using stress-response promoters

The problem of toxic intermediates in engineered metabolic pathways is mitigated by dynamic gene-expression regulation using stress-responsive promoters.

Robert H Dahl
Fuzhong Zhang
Jay D Keasling

Special:

Synthetic Biology
Article 01 Nov 2013
Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1–neutralizing activity

Strategic insertion of an N-linked glycan into the variable domain of an antibody improves its ability to inhibit HIV-1 infection.

Ruijiang Song
Deena A Oren
David D Ho
Article 01 Nov 2013

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Careers and Recruitment

Third-quarter biotech job picture

Michael Francisco
Careers and Recruitment 01 Nov 2013
People

Careers and Recruitment 01 Nov 2013

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Volume 31 Issue 11, November 2013

Editorial

News

Data Page

News Feature

Bioentrepreneur

Correspondence

Commentary

Patents

News & Views

Commentary

Review Article

Article

Careers and Recruitment

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