Receptive to replication
Do replication studies belong in top-tier journals?
The 2009 H1N1 pandemic showed that the egg-based technology used to produce the bulk of flu vaccine is not nimble enough to protect during a pandemic. Charles Schmidt reports on progress in synthetic and recombinant technologies that may provide an answer.
Which investment firms are currently actively investing in new biomedical startups?
New technology has transformed human genetics. It now provides perhaps the single best opportunity to innovate and improve clinical success rates in drug development.
Too few precompetitive consortia are being formed to mitigate lost opportunities and deliver on other potential mutual gains for public and private stakeholders in drug development.
A study assesses Chinese scientists' knowledge of patents and the relationship between scientists' patent-using behaviors and their organizations' mandates.
Pools of cell lines carrying a variety of known mutations are used to validate the performance of a cancer diagnostic test based on next-generation sequencing.
A dual-view light-sheet microscope combines isotropic spatial resolution with high speed and minimal phototoxicity.
A genetically encoded voltage indicator enables robust optical recording of membrane voltage changes in the fly brain.
Two computational biologists give advice when starting out on computational projects.
Sequencing the human transcriptome using long, single-molecule reads identifies new transcript isoforms.
RNA sequencing of 465 human lymphoblastoid cell lines across seven European laboratories shows the feasibility of transcriptome sequencing for population-wide and cross-biobank studies.
Clinical tests that rely on next-generation sequencing to evaluate large numbers of cancer genes can be validated using pooled cell lines with known mutations.
A dual-view light sheet microscope allows high-speed imaging with an isotropic spatial resolution
The problem of toxic intermediates in engineered metabolic pathways is mitigated by dynamic gene-expression regulation using stress-responsive promoters.
Strategic insertion of an N-linked glycan into the variable domain of an antibody improves its ability to inhibit HIV-1 infection.